DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and NRPD2A

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_001189957.1	Gene:	NRPD2A / 821960	AraportID:	AT3G23780	Length:	1172	Species:	Arabidopsis thaliana

Alignment Length:	1233	Identity:	379/1233 - (30%)
Similarity:	586/1233 - (47%)	Gaps:	180/1233 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MGDHNVEATTWDPGDSKDWSVPIKPLTEKW------KLVPAFLQVKGLVKQHIDSFNHFINVDIK 64
            |.|.:::....:..::....:.:..|.|.:      |...:|....||:...::|:|:||...::
plant     1 MPDMDIDVKDLEEFEATTGEINLSELGEGFLQSFCKKAATSFFDKYGLISHQLNSYNYFIEHGLQ 65

  Fly    65 KIVKA-NELVTSGADPLF-------------YLKYLDVRVGKPDIDDGFNITKAT--TPHECRLR 113
            .:.:: .|::   .:|.|             .:|:.:|.|.||..   |:..|..  .|...||:
plant    66 NVFQSFGEML---VEPSFDVVKKKDNDWRYATVKFGEVTVEKPTF---FSDDKELEFLPWHARLQ 124

  Fly   114 DTTYSAPITVDIE-------------YTRGTQR--------IKRNNLLIGRMPLMLRCSNCALTG 157
            :.||||.|.|:::             :..|...        :|:.::|||.:|:|::...|..:.
plant   125 NMTYSARIKVNVQVEVFKNTVVKSDKFKTGQDNYVEKKILDVKKQDILIGSIPVMVKSILCKTSE 189

  Fly   158 KSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLS----W--NKMLTEDFNG-------VVQCQ 209
            |.: |..|..:|..|.|||||::|.|||.:.|||:.    |  |...|..|..       :|:..
plant   190 KGK-ENCKKGDCAFDQGGYFVIKGAEKVFIAQEQMCTKRLWISNSPWTVSFRSENKRNRFIVRLS 253

  Fly   210 VTSSTHEKKSRTLVLSKHGKYYLKHNSMTDDIPIVVIFKALGVVSDQEIQSLI---GIDSKSQNR 271
            ......:.|.|..||:   .|:|     :.:||:.::|.||||.||:|...||   |.|:...|.
plant   254 ENEKAEDYKRREKVLT---VYFL-----STEIPVWLLFFALGVSSDKEAMDLIAFDGDDASITNS 310

  Fly   272 FGASL--IDAYNLKVFTQQRALEYMGSKLVVKRFQSATTKTPSEEARELLLTTILAHVPVDNFNL 334
            ..||:  .||..........||.|:..::...:|      .|:|...|.|...:...:.    :|
plant   311 LIASIHVADAVCEAFRCGNNALTYVEQQIKSTKF------PPAESVDECLHLYLFPGLQ----SL 365

  Fly   335 QMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNWELKT-IADKN 398
            :.||.::..||:.::.:...|...::||.:.|||:||||.||..           |::. :|...
plant   366 KKKARFLGYMVKCLLNSYAGKRKCENRDSFRNKRIELAGELLER-----------EIRVHLAHAR 419

  Fly   399 IPKVKAAQFDVVKHMR-------------AAQITAGLESAISSGNWTIKRFKMER-AGVTQVLSR 449
            ....:|.|    ||:.             |:.||.||..|.|:|.|:....|||| :||...|.|
plant   420 RKMTRAMQ----KHLSGDGDLKPIEHYLDASVITNGLSRAFSTGAWSHPFRKMERVSGVVANLGR 480

  Fly   450 LSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVE 514
            .:.:..|..:.|...|...|.||...|...||.||.:|...||:||.||||||::|:..::|:..
plant   481 ANPLQTLIDLRRTRQQVLYTGKVGDARYPHPSHWGRVCFLSTPDGENCGLVKNMSLLGLVSTQSL 545

  Fly   515 ERPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRKGRMGSYV 579
            | .|:...|..|:|::.:.:..|:...:  .|.:||:.:||..:.:..|..|:..||:..:...:
plant   546 E-SVVEKLFACGMEELMDDTCTPLFGKH--KVLLNGDWVGLCADSESFVAELKSRRRQSELPREM 607

  Fly   580 SVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNE 644
            .:........:.|.||.|||.||.::|||.:.| ||....:.     .||..|..|::|.:.:.|
plant   608 EIKRDKDDNEVRIFTDAGRLLRPLLVVENLQKL-KQEKPSQY-----PFDHLLDHGILELIGIEE 666

  Fly   645 ENDSFIAWNEDQI--EDRT-THLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQ----CAMGKQAMG 702
            |.|...||...|:  |.:. ||.|::...||||...:||:.:|:...|..||    |   :||:|
plant   667 EEDCNTAWGIKQLLKEPKIYTHCELDLSFLLGVSCAVVPFANHDHGRRVLYQSQKHC---QQAIG 728

  Fly   703 MIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSGYDIEDALILNKA 767
            ....|...|.|:|...|.||..|:.|:...|....:.|..||||.|||..:.||:.||::::|||
plant   729 FSSTNPNIRCDTLSQQLFYPQKPLFKTLASECLKKEVLFNGQNAIVAVNVHLGYNQEDSIVMNKA 793

  Fly   768 SIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMKDALTNKVIFKHDVLDTDGIVAPGEQVQNKQ 832
            |::||..|....::.|..|....::...::...::...|:..|.|.|.|:.||....|..:....
plant   794 SLERGMFRSEQIRSYKAEVDAKDSEKRKKMDELVQFGKTHSKIGKVDSLEDDGFPFIGANMSTGD 858

  Fly   833 IMINK--EMPAVTSMNPLQGQSAQVPYTAVPISYKGPEPSYIERVMVSANAEEDFLIKILLRQTR 895
            |:|.:  |..|..|                 |..|..|...:::|::|:|.|......:.|||.|
plant   859 IVIGRCTESGADHS-----------------IKLKHTERGIVQKVVLSSNDEGKNFAAVSLRQVR 906

  Fly   896 IPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTVGKTLELLGGKAGLL 960
            .|.:||||||.||||||.|.:.||::.||...||.||:::|||.||||.|.|:.||....| |:.
plant   907 SPCLGDKFSSMHGQKGVLGYLEEQQNFPFTIQGIVPDIVINPHAFPSRQTPGQLLEAALSK-GIA 970

  Fly   961 -----EGK-------FHYGTAFGGSKVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIYSGPV 1013
                 ||.       ..:.|.|....|.:|..:|.|.||:..|.:..|:|.:|..:.:.|:.||.
plant   971 CPIQKEGSSAAYTKLTRHATPFSTPGVTEITEQLHRAGFSRWGNERVYNGRSGEMMRSMIFMGPT 1035

  Fly  1014 YYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISS 1078
            :||:|.||.:||:..|..||...|||||...|.|.||::.|||||||||::|||..:.|||...|
plant  1036 FYQRLVHMSEDKVKFRNTGPVHPLTRQPVADRKRFGGIKFGEMERDCLIAHGASANLHERLFTLS 1100

  Fly  1079 DAFEVDVCRTC-------------GRMAYCSWCHFCQSSANVSKISMPYACKLLFQELTSMNV 1128
            |:.::.:||.|             ||.....:|..|.||.:|.::.:||..|||.|||.||.:
plant  1101 DSSQMHICRKCKTYANVIERTPSSGRKIRGPYCRVCVSSDHVVRVYVPYGAKLLCQELFSMGI 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	375/1205 (31%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	372/1186 (31%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	44/164 (27%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	17/60 (28%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	15/42 (36%)
NRPD2A	NP_001189957.1	RNA_pol_B_RPB2	48..1168	CDD:238353	372/1186 (31%)
NRPD2A	NP_001189957.1	RNA_pol_Rpb2_4	574..635	CDD:398322	17/60 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720