DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and polr3b

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	XP_021323450.1	Gene:	polr3b / 562329	ZFINID:	ZDB-GENE-030131-2887	Length:	1130	Species:	Danio rerio

Alignment Length:	1116	Identity:	769/1116 - (68%)
Similarity:	927/1116 - (83%)	Gaps:	5/1116 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVPIKPLTEKWKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFYLKYLDVR 89
            :.|:..:.|||||:||||:|||||||||||||:||||:||||:||||.:||.|||::|||||::.
Zfish    15 AAPVDTVEEKWKLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKITSDADPMWYLKYLNIY 79

  Fly    90 VGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYTRGTQRIKRNNLLIGRMPLMLRCSNCA 154
            ||.||:::.||:|:..:||||||||.|||||||||||||||:|||.||.|.|||||:|||.|||.
Zfish    80 VGMPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCV 144

  Fly   155 LTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLT-EDFNGVVQCQVTSSTHEKK 218
            ||||:..|.||||||||||||||:|:|||||||||||||.|:::. :|..|.|...|||||||||
Zfish   145 LTGKTPMEFSKLNECPLDPGGYFIVKGQEKVILIQEQLSKNRIIVDQDRKGTVGASVTSSTHEKK 209

  Fly   219 SRTLVLSKHGKYYLKHNSMTDDIPIVVIFKALGVVSDQEIQSLIGIDSKSQNRFGASLIDAYNLK 283
            |||.::.|.|::|||||::::|.||.:||||:||.|||||..:||.:......|..||.:....:
Zfish   210 SRTNMIVKQGRFYLKHNTLSEDAPIAIIFKAMGVESDQEIVQMIGTEEHVMAAFAPSLEECQKAQ 274

  Fly   284 VFTQQRALEYMGSKLVVKRFQSATTKTPSEEARELLLTTILAHVPVDNFNLQMKAIYVSMMVRRV 348
            :|||.:||.|:|:|:..:|......||..|||||||.:|||.||||..||.:.|.||:::|||||
Zfish   275 IFTQTQALRYIGNKVRRQRMWGGPKKTKMEEARELLASTILTHVPVKEFNFRAKCIYLAVMVRRV 339

  Fly   349 MAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNWELKTIADKNIPKVKAAQFDVVKHM 413
            :.|:.|..: |||||||||||||||.|||::||||||:.|.|||.|||:.|||.:||||||||||
Zfish   340 ILAQGDNKV-DDRDYYGNKRLELAGQLLSLLFEDLFKKFNSELKKIADQIIPKQRAAQFDVVKHM 403

  Fly   414 RAAQITAGLESAISSGNWTIKRFKMERAGVTQVLSRLSYISALGMMTRVNSQFEKTRKVSGPRSL 478
            |..|||.|:.:|||:|||::|||||:|.||||||||||:|||||||||::|||||||||||||||
Zfish   404 RQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSFISALGMMTRISSQFEKTRKVSGPRSL 468

  Fly   479 QPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVEERPVMIVAFNAGVEDIREVSGNPINNPNV 543
            |||||||||||||||||||||||||||||||||::|:.|::.:|||.||||:..:.|..::.|.|
Zfish   469 QPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIIKLAFNLGVEDVNLLCGEELSYPTV 533

  Fly   544 FLVFINGNVLGLTLNHKHLVRNLRYMRRKGRMGSYVSVHTSYTQRCIYIHTDGGRLCRPYVIVEN 608
            ||||:|||:||:..:|:.||...|.|||.|.:..:||:.|:.|.||:||.:|||||||||:||:|
Zfish   534 FLVFLNGNILGVIRDHQKLVYTFRLMRRAGFINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKN 598

  Fly   609 RRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDRTTHLEIEPFTLLG 673
            .:|.||..|::||::|.|.|:|||.:.|:||||||||||..||..|..|...|||||||||||||
Zfish   599 GKPAVKNKHIEELSQGYRTFEDFLHESLVEYLDVNEENDCNIALYEHMISKDTTHLEIEPFTLLG 663

  Fly   674 VCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFD 738
            |||||:|||||||||||||||||||||||.|||||:||||:|||.|.||..||||:|||||.:|:
Zfish   664 VCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQRPMVKTKTIELIDFE 728

  Fly   739 KLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMKD 803
            ||||||||||||||||||||||||:|||||:|||:||||||||:|||::||.|||||::||||.|
Zfish   729 KLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLRRYTNQTFDKVMGPMLD 793

  Fly   804 ALTNKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQG--QSAQVPYTAVPISYKG 866
            |.|.|.|::|.:||.|||.:|||:|:|||:::||.||.|| ..||:|  |..|..|..||:||||
Zfish   794 AETRKPIWRHSILDADGICSPGEKVENKQVLVNKSMPTVT-QTPLEGSAQPGQPQYREVPVSYKG 857

  Fly   867 PEPSYIERVMVSANAEEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICP 931
            ...||||:||:|:|||:.||:||||||||.||||||||||||||||.||||.||||||.|.||||
Zfish   858 ATDSYIEKVMISSNAEDAFLVKILLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICP 922

  Fly   932 DMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAFGGSKVEDIQAELERHGFNYVGKDFFY 996
            |:||||||:||||||||.:|||.||||:|:|:||||||||||||:|:..:|.|:|:||.|||:..
Zfish   923 DIIMNPHGYPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLIRYGYNYQGKDYVT 987

  Fly   997 SGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCL 1061
            |||||.|||||||.||||||||||||.||||||||||:||||||||:||||:|||||||||||||
Zfish   988 SGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCL 1052

  Fly  1062 ISYGASMLIMERLMISSDAFEVDVCRTCGRMAYCSWCHFCQSSANVSKISMPYACKLLFQELTSM 1126
            |.||||||::|||||||||||||||..||.:.|..|||:|:||.:||.:.:|||||||||||.||
Zfish  1053 IGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSM 1117

  Fly  1127 NVVPKMILENY 1137
            |::|::.|..|
Zfish  1118 NIIPRLKLARY 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	765/1103 (69%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	754/1088 (69%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	85/159 (53%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	33/60 (55%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	25/39 (64%)
polr3b	XP_021323450.1	RNA_pol_B_RPB2	37..1124	CDD:238353	754/1088 (69%)
		RNA_pol_Rpb2_4	536..597	CDD:309626	33/60 (55%)
		RNA_pol_Rpb2_5	618..658	CDD:309627	25/39 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580576
Domainoid	1	1.000	598	1.000	Domainoid score	I192
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6981
Inparanoid	1	1.050	1591	1.000	Inparanoid score	I80
OMA	1	1.010	-	-		QHG54037
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	1	1.000	-	-		oto39198
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	1	1.100	-	-	LDO	PTHR20856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1190
SonicParanoid	1	1.000	-	-		X610
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800