Protein Alignment Polr3B and POLR3B

DIOPT Version :10

• Sequence 1: NP_523706.1
• Gene: Polr3B / 36289
• FlyBaseID: FBgn0004463
• Length: 1137
• Species: Drosophila melanogaster
• Sequence 2: NP_060552.4
• Gene: POLR3B / 55703
• HGNCID: 30348
• Length: 1133
• Species: Homo sapiens
• Alignment Length: 1117
• Identity: 772/1117 - (69%)
• Similarity: 929/1117 - (83%)
• Gaps: 6/1117 - (0%)

  Fly    25 SVPIKPLTEKWKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFYLKYLDVR 89
            :.||..:.|||:|:||||:|||||||||||||:||||:||||:||||.|||.|||::|||||::.
Human    17 AAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIY 81

  Fly    90 VGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYTRGTQRIKRNNLLIGRMPLMLRCSNCA 154
            ||.||:::.||:|:..:||||||||.|||||||||||||||:|||.||.|.|||||:|||.|||.
Human    82 VGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCV 146

  Fly   155 LTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLTE-DFNGVVQCQVTSSTHEKK 218
            ||||:..|.:|||||||||||||:|:|.|||||||||||.|:::.| |..|.|...|||||||||
Human   147 LTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKK 211

  Fly   219 SRTLVLSKHGKYYLKHNSMTDDIPIVVIFKALGVVSDQEIQSLIGIDSKSQNRFGASLIDAYNLK 283
            |||.:..|.|::||:||::::|||||:||||:||.|||||..:||.:......||.||.:....:
Human   212 SRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQ 276

  Fly   284 VFTQQRALEYMGSKLVVKR-FQSATTKTPSEEARELLLTTILAHVPVDNFNLQMKAIYVSMMVRR 347
            :|||.:||:|:|:|:..:| :.....||..|||||||.:|||.||||..||.:.|.||.::||||
Human   277 IFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRR 341

  Fly   348 VMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNWELKTIADKNIPKVKAAQFDVVKH 412
            |:.|:.|..: |||||||||||||||.|||::||||||:.|.|:|.|||:.|||.:|||||||||
Human   342 VILAQGDNKV-DDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKH 405

  Fly   413 MRAAQITAGLESAISSGNWTIKRFKMERAGVTQVLSRLSYISALGMMTRVNSQFEKTRKVSGPRS 477
            ||..|||.|:.:|||:|||::|||||:|.||||||||||||||||||||::||||||||||||||
Human   406 MRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRS 470

  Fly   478 LQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVEERPVMIVAFNAGVEDIREVSGNPINNPN 542
            ||||||||||||||||||||||||||||||||||::|:.|::.:|.|.||||:..:.|..::.||
Human   471 LQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPN 535

  Fly   543 VFLVFINGNVLGLTLNHKHLVRNLRYMRRKGRMGSYVSVHTSYTQRCIYIHTDGGRLCRPYVIVE 607
            |||||:|||:||:..:||.||...|.|||.|.:..:||:.|:.|.||:||.:|||||||||:||:
Human   536 VFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVK 600

  Fly   608 NRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDRTTHLEIEPFTLL 672
            .::|.|...|::||.:|.|.|:|||.:.|:||||||||||..||..|..|...||||||||||||
Human   601 KQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLL 665

  Fly   673 GVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNF 737
            ||||||:|||||||||||||||||||||||.|||||:||||:|||.|.||..||||:|||||..|
Human   666 GVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEF 730

  Fly   738 DKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMK 802
            :||||||||||||||||||||||||:|||||:|||:||||||||:|||:|||.|||||::||||.
Human   731 EKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPML 795

  Fly   803 DALTNKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSA--QVPYTAVPISYK 865
            ||.|.|.|::|::||.|||.:|||:|:|||:::||.||.||.: ||:|.:.  |..|..|||:||
Human   796 DAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQI-PLEGSNVPQQPQYKDVPITYK 859

  Fly   866 GPEPSYIERVMVSANAEEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGIC 930
            |...||||:||:|:|||:.||||:||||||.||||||||||||||||.||||.||||||.|.|||
Human   860 GATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGIC 924

  Fly   931 PDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAFGGSKVEDIQAELERHGFNYVGKDFF 995
            ||:|||||||||||||||.:|||.||||:|:|:||||||||||||:|:..:|.|||:||:|||:.
Human   925 PDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYV 989

  Fly   996 YSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDC 1060
            .|||||.|||||||.||||||||||||.||||||||||:||||||||:||||:||||||||||||
Human   990 TSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDC 1054

  Fly  1061 LISYGASMLIMERLMISSDAFEVDVCRTCGRMAYCSWCHFCQSSANVSKISMPYACKLLFQELTS 1125
            ||.||||||::|||||||||||||||..||.:.|..|||:|:||.:||.:.:|||||||||||.|
Human  1055 LIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQS 1119

  Fly  1126 MNVVPKMILENY 1137
            ||::|::.|..|
Human  1120 MNIIPRLKLSKY 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr3B	NP_523706.1	RNA_pol_B_RPB2	47..1133	CDD:238353	757/1089 (70%)
		RNA_pol_Rpb2_4	546..607	CDD:428012	34/60 (57%)
		RNA_pol_Rpb2_5	628..668	CDD:428013	25/39 (64%)
POLR3B	NP_060552.4	RNA_pol_B_RPB2	39..1127	CDD:238353	757/1089 (70%)
		RNA_pol_Rpb2_4	539..600	CDD:428012	34/60 (57%)
		RNA_pol_Rpb2_5	621..661	CDD:428013	25/39 (64%)