Protein Alignment Polr3B and Polr2B

DIOPT Version :10

• Sequence 1: NP_523706.1
• Gene: Polr3B / 36289
• FlyBaseID: FBgn0004463
• Length: 1137
• Species: Drosophila melanogaster
• Sequence 2: NP_476706.1
• Gene: Polr2B / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Alignment Length: 1160
• Identity: 427/1160 - (36%)
• Similarity: 669/1160 - (57%)
• Gaps: 72/1160 - (6%)

  Fly    35 WKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELV--------TSG---ADPLFYLKYLDV 88
            |.::.|:...||||:|.:|||:.||.:.:::||:.:..:        |||   ..|.|.||:..:
  Fly    28 WIVINAYFDEKGLVRQQLDSFDEFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPPRFSLKFEQI 92

  Fly    89 RVGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYTRGTQRI-----KRNNLLIGRMPLML 148
            .:.||...:.........|:|.|||:.|||||:.|||..|:..:.:     :.....||::|:||
  Fly    93 YLSKPTHWEKDGSPSPMMPNEARLRNLTYSAPLYVDITKTKNVEGLDPVETQHQKTFIGKIPIML 157

  Fly   149 RCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLT---EDFNGVVQCQV 210
            |.:.|.|:..::.:|::||||||||||||::.|.|||::.||:::.|.:..   :|.....:.::
  Fly   158 RSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFSMKDGKYAFKTEI 222

  Fly   211 TSSTHEKKSRTLVL----SKHGKYYLKHNS-----------MTDDIPIVVIFKALGVVSDQEIQS 260
            .|........|..|    ...|...:|.::           :..:|||:::|:|||.|:|::|..
  Fly   223 RSCLEHSSRPTSTLWVNMMARGSQNIKKSAIGQRIIAILPYIKQEIPIMIVFRALGFVADRDILE 287

  Fly   261 LIGI---DSKSQNRFGASLIDAYNLKVFTQQRALEYMGSKLVVKRFQSATTKTPS-EEARELLLT 321
            .|..   |.:.......||.:|:  .|..|..||.::|:    :..:...||... :.|:|:|..
  Fly   288 HIIYDFDDPEMMEMVKPSLDEAF--VVQEQNVALNFIGA----RGARPGVTKDKRIKYAKEILQK 346

  Fly   322 TILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKR 386
            .:|.||.|.:|....||.::..||.|::.|.|.:...||||:||||||:|||.||:.:|..|||.
  Fly   347 EMLPHVGVSDFCETKKAYFLGYMVHRLLLASLGRRELDDRDHYGNKRLDLAGPLLAFLFRGLFKN 411

  Fly   387 MNWELKTIADKNIPKVKAAQFDVVKHMRAAQITAGLESAISSGNW-TIKRFKMERAGVTQVLSRL 450
            :..|::....|.|.:.|  .|::...::...||.||..::::||| ..|:....||||:|||:||
  Fly   412 LMKEVRMYTQKFIDRGK--DFNLELAIKTNIITDGLRYSLATGNWGDQKKAHQARAGVSQVLNRL 474

  Fly   451 SYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVEE 515
            ::.|.|..:.||||...:..|::.||.|..:.||||||::||||.|.|||||||||.:|:...:.
  Fly   475 TFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPAETPEGAAVGLVKNLALMAYISVGSQP 539

  Fly   516 RPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRK-GRMGSYV 579
            .|::.......:|::.|::.:.|  .:...:|:||..:|:..:.:.|:..||.:||: ..:.|.|
  Fly   540 SPILEFLEEWSMENLEEIAPSAI--ADATKIFVNGCWVGIHRDPEQLMATLRKLRRQMDIIVSEV 602

  Fly   580 SVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRKFDDF-----LLDGLIEY 639
            |:......|.|.|:||.||:|||.:||||...|:|:.|::.|..  |.::::     :..|::||
  Fly   603 SMIRDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKE--RDYNNYSWQVLVASGVVEY 665

  Fly   640 LDVNEENDSFIAWNE-DQIEDRT-------THLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAM 696
            :|..||....||.:. |..:|:.       ||.||.|..:|||||.::|:|.||||||||||.||
  Fly   666 IDTLEEETVMIAMSPYDLKQDKDYAYCTTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAM 730

  Fly   697 GKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSGYDIEDA 761
            ||||||:...|...|:|:|.:.|.||..|:|.::::|...|.:||||.|:.||::.|:||:.||:
  Fly   731 GKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGINSIVAILCYTGYNQEDS 795

  Fly   762 LILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMKDALTNKVIFKHDVLDTDGIVAPGE 826
            :|||.::::||:.|.:.|::.|.:..:......:....|.:..........:|.||.|||:|||.
  Fly   796 VILNASAVERGFFRSVFYRSYKDSENKRVGDQEENFEKPHRGTCQGMRNAHYDKLDDDGIIAPGI 860

  Fly   827 QVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAVPISYKGPEPSYIERVMVSANAEEDFLIKILL 891
            :|....::|.|.:....:.:.|...:.:..........:..|...:::||::.|:|.....||.:
  Fly   861 RVSGDDVVIGKTITLPENDDELDSNTKRFSKRDASTFLRNSETGIVDQVMLTLNSEGYKFCKIRV 925

  Fly   892 RQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTVGKTLELLGGK 956
            |..|||:|||||:|||||||..|:...||||.|...|:.||:|:|||..|||||:|..:|.|.||
  Fly   926 RSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDIIINPHAIPSRMTIGHLIECLQGK 990

  Fly   957 AGLLEGKFHYGTAFGGS-KVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQKLKH 1020
            .|..:|:....|.|..: .|:.|...|:.:|::..|.:..|:|.||..:.|.::.||.|||:|||
  Fly   991 LGSNKGEIGDATPFNDAVNVQKISTFLQEYGYHLRGNEVMYNGHTGRKINAQVFLGPTYYQRLKH 1055

  Fly  1021 MVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDAFEVDV 1085
            ||.||:|:|||||..:|.|||.:||:|:||||.|||||||.||:||:..:.|||...||.:.|.:
  Fly  1056 MVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISHGAAQFLRERLFEVSDPYRVHI 1120

  Fly  1086 CRTCGRMAYCSW------CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKMIL 1134
            |..||.:|..:.      |..|::...:|::.:|||.|||||||.|||:.|::::
  Fly  1121 CNFCGLIAIANLRNNTFECKGCKNKTQISQVRLPYAAKLLFQELMSMNIAPRLMV 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr3B	NP_523706.1	RNA_pol_B_RPB2	47..1133	CDD:238353	423/1145 (37%)
		RNA_pol_Rpb2_4	546..607	CDD:428012	23/61 (38%)
		RNA_pol_Rpb2_5	628..668	CDD:428013	14/52 (27%)
Polr2B	NP_476706.1	Ricin_B_lectin	28..1176	CDD:481363	427/1160 (37%)