DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and polr1b

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_956812.2	Gene:	polr1b / 325603	ZFINID:	ZDB-GENE-040426-1598	Length:	1132	Species:	Danio rerio

Alignment Length:	1205	Identity:	351/1205 - (29%)
Similarity:	547/1205 - (45%)	Gaps:	190/1205 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IKPLTEKWKLVPAFLQ---VKGLVKQHIDSFNHFINVDIKKIVKA---NELVTSGADPLFYLKYL 86
            :|.|||....||...|   |:.|||.||:||:..:...:.::|:|   .|.:..|  ....|.::
Zfish    15 LKHLTEAGFGVPKEKQRVPVQELVKAHIESFDQAVTDGLCRVVEAIPPMEFLYKG--DRISLSFV 77

  Fly    87 DVRVGKPDIDDGFNITK--ATTPHECRLRDTTYSAPITVDIEYT-RGTQR--IKRNNLLIGRMPL 146
            :..:..|.:..| .|::  ...|.|||.|..||.|.:..|:.:: .|..:  ||::   :|:||:
Zfish    78 EAIIHTPSVSKG-GISRDLRVFPAECRGRRCTYRAKLVADVSWSVNGVPKGIIKQS---LGQMPI 138

  Fly   147 MLRCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVI--LIQEQLSW-----NKMLTEDFNG 204
            |::...|.|.|.|..||.:.:|...:.||||:|.|.||||  ||..:.::     .........|
Zfish   139 MVKSKLCNLHGLSPKELLEHHEEAEEMGGYFIVNGIEKVIRLLIMPRRNYPIAVSRPKFKSRGQG 203

  Fly   205 VVQCQVTSSTHEKKSRTLVLSKHGKYYLKHNSMTDD---------IPIVVIFKALGVVSDQEI-Q 259
            ..|..::....:::...:.::.|   ||.:.::..:         :|:....|||...||.:| |
Zfish   204 YTQYAISMRCVKEEHTAINMNLH---YLDNGTVMVNFIYRKELFFLPLGFALKALVDYSDYQIYQ 265

  Fly   260 SLIGIDSKSQNRFGASLIDAYNLKVFTQQ------RALEYMGSKLVVKRFQSATTKTPS----EE 314
            .|  |..:..|.|..|.:... |::...|      :.|.|:|.:..||      ...|.    |:
Zfish   266 EL--IKGREDNSFYKSCVSEM-LRIVMDQGCTTKIKVLNYLGERFRVK------LNLPEWFTHEQ 321

  Fly   315 ARELLLTTILA-HVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSM 378
            ....||...|. |:..|.....|    :.:|.|::.:....:.:.::.|......:...|.|..|
Zfish   322 CAHFLLDECLCIHLKTDVEKFYM----LCLMTRKLFSFAKQECMEENPDSPMFHEVLTPGQLYLM 382

  Fly   379 MFEDLFKRMNW--ELKTIADKNIPKVKAAQFDVVKHM--RAAQITAGLESAISSGNWTIKR--FK 437
            ..::  |...|  .:|...:|...:|.....|.:..:  ....:|...|..:::||...|.  ..
Zfish   383 FLKE--KMEGWLVSVKLALEKKPQRVGGLTPDSMTKLFNMGTDLTKAFEYLLATGNLMSKTGLGM 445

  Fly   438 MERAGVTQVLSRLSYISALGMMTRVN--SQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLV 500
            ::.:|:..|..:|::|..|.....|:  :.|.|.|..: .|.|.|..||.|||..||:||.||
Zfish   446 LQNSGLCVVADKLNFIRYLSHFRCVHRGAAFAKMRTTT-VRKLLPESWGFLCPVHTPDGEPCG-- 507

  Fly   501 KNLALMTHITTEVE---------ERPVMIVAFNAGVEDIREVSGNPIN-NPNVFLVFINGNVLGL 555
                ||.|:|...|         ..|.::.:......|     |||.. ..:.:.|.::|.::|.
Zfish   508 ----LMNHMTAHCEIVAPVYPTSTLPGLLCSLGVNAAD-----GNPGQAYSDCYPVILDGAMIGW 563

  Fly   556 TLNH--KHLVRNLRYMR-----------------RKGRMGSYVSVHTSYTQRCIYIHTDGGRLCR 601
            ....  ..::.:||..:                 :.|:...|..::. :|..|..:.|
Zfish   564 VEKEVAPSVIESLRRFKVLGEKKVPPWTEIVLVPQTGKASLYPGLYL-FTTPCRMVRT------- 620

  Fly   602 PYVIVENRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDR-TTHLE 665
                |.|            |:.|.::     |.|:.|.:.:|      :...|.:|||. |||.|
Zfish   621 ----VRN------------LSLGKQE-----LIGIFEQVYLN------VGIFEKEIEDGVTTHQE 658

  Fly   666 IEPFTLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSK 730
            :.|.::|.|.|..:|:..|||||||.|||.|.||.||...::.:.|.|:.:|.|..|.:|:|:..
Zfish   659 LFPHSMLSVVAEFIPFSDHNQSPRNMYQCQMSKQTMGFPLHSYQYRSDNKLYRLQTPQSPLVRPA 723

  Fly   731 TIELTNFDKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFD 795
            ..:..:.|..|.|.||.|||:||:|||:|||:|:||:|.:||:....|||.....:....... |
Zfish   724 MYDHYDVDNYPIGTNAIVAVISYTGYDMEDAMIVNKSSWERGFAHGSVYKTEIIDLSEKVKGD-D 787

  Fly   796 RIMGPMKDALTNKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAV 860
            .|:..:|.. ..||:.|   ||.||:...|..::     .........|:|  .||| .|.:
Zfish   788 SIVFGVKPG-DPKVMGK---LDADGLPFIGSVLK-----YGDPFYGYISLN--TGQS-HVYF--- 837

  Fly   861 PISYKGPEPSYIERVMVSANAEEDFLIK---ILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDM 922
               ||..|...::.:.|.:|.......|   :..|..|.|.|||||:|||||||:...:...|||
Zfish   838 ---YKYQESCVVDNIKVCSNETGTGRFKRICVTSRVPRNPTIGDKFASRHGQKGILSRLWPAEDM 899

  Fly   923 PFNDFGICPDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAF----GGSKVEDIQAELE 983
            ||.:.|:.||::.||||||||||:|..:|.:.||:..|.|..|..|.|    ..|.:|.....|:
Zfish   900 PFTESGMSPDILFNPHGFPSRMTIGMLIESMAGKSASLHGLCHDATPFTFSEENSALEHFGELLK 964

  Fly   984 RHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSRE 1048
            ..|:||.|.:..|||::|..|||.|:.|.||||:|:|||.||...|..|.:..:|.||..||:.:
Zfish   965 AAGYNYYGTERLYSGLSGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPMGGRNVQ 1029

  Fly  1049 GGLRLGEMERDCLISYGASMLIMERLMISSDAFEVDVCRTCGRMAYC-------SW--------- 1097
            ||:|.||||||.|:::|.|.|:.:||...||.....||..||.:...       :|
Zfish  1030 GGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAQVCMDCGSLLSTLLEKPPPNWSATRHRKTI 1094

  Fly  1098 CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKM 1132
            |..|..|.::..:|:||..|....||.:||:..|:
Zfish  1095 CLLCNKSDSIETVSVPYVFKYFVAELAAMNIKIKL 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	347/1199 (29%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	343/1183 (29%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	34/180 (19%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	10/79 (13%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	12/40 (30%)
polr1b	NP_956812.2	RpoB	16..1132	CDD:223163	351/1204 (29%)
		RNA_pol_B_RPB2	37..1130	CDD:238353	343/1183 (29%)
		RNA_pol_Rpa2_4	561..614	CDD:284335	6/53 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820