DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and Polr1b

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_033112.2	Gene:	Polr1b / 20017	MGIID:	108014	Length:	1135	Species:	Mus musculus

Alignment Length:	1207	Identity:	347/1207 - (28%)
Similarity:	553/1207 - (45%)	Gaps:	192/1207 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IKPLTEKWKLVPAFLQ---VKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFYLKYLDVR 89
            :|.||:....:|...|   ::.|.:.|:||||:.....:...|:        |.|.|...:.|.|
Mouse    16 LKHLTDPSYGIPPEQQKAALQDLTRAHVDSFNYAALEGLSHAVQ--------AIPPFEFAFKDER 72

  Fly    90 VGKPDIDDGF---NITKATT-------PHECRLRDTTYSAPITVDIEY-TRGTQR--IKRNNLLI 141
            :....:|...   ::.|.|.       |.|||.|.:||...:|.||.: ..|..:  ||:   .:
Mouse    73 ISLTIVDAVISPPSVPKGTICKDLNVYPAECRGRKSTYRGRLTADISWAVNGVPKGIIKQ---FL 134

  Fly   142 GRMPLMLRCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVI-------------LIQEQLS 193
            |.:|:|::...|.|.......|.:.:|...:.||||::.|.||||             :::.:..
Mouse   135 GYVPIMVKSKLCNLYNLPPRVLIEHHEEAEEMGGYFIINGIEKVIRMLIVPRRNFPIAMVRPKWK 199

  Fly   194 WNKMLTEDFNGVVQC------QVTSSTHEKKSRTLVLS---KHGKYYLKHNSMTDDIPIVVIFKA 249
            ...:....|...::|      .|..:.|..::.|::|:   :...::|         |:....||
Mouse   200 SRGLGYTQFGVSMRCVREEHSAVNMNLHYVENGTVMLNFIYRKELFFL---------PLGFALKA 255

  Fly   250 LGVVSDQEI-QSLIGIDSKSQNRFGASLIDAYNLKV------FTQQRALEYMGSKLVVKRFQSAT 307
            |...||.:| |.|  |..|.::.|..:.: :..|::      .:|::.|.|:|....||  .|..
Mouse   256 LVSFSDYQIFQEL--IKGKEEDSFFRNSV-SQMLRIVIEEGCHSQKQVLNYLGECFRVK--LSLP 315

  Fly   308 TKTPSEEARELLLT-TILAHVP--VDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRL 369
            ...|:.||.|.||. .|..|:.  .|.|.|      :.:|.|::.|....:.:.|:.|...|:.:
Mouse   316 DWYPNVEAAEFLLNQCICIHLQSNTDKFYL------LCLMTRKLFALARGECMDDNPDSLVNQEV 374

  Fly   370 ELAGSLLSMMFEDLFKRMNW--ELKTIADKNIPK--VKAAQFDVVK-HMRAAQITAGLESAISSG 429
            ...|.|..|..::  |..||  .:|.:.||...|  |.....:::| .....::|...|..:::|
Mouse   375 LSPGQLFLMFLKE--KMENWLVSIKIVLDKRAQKANVSINNENLMKIFSMGTELTRPFEYLLATG 437

  Fly   430 NWTIKR---FKMERAGVTQVLSRLSYISALGMMTRVN--SQFEKTRKVSGPRSLQPSQWGMLCPS 489
            |...|.   | ::.:|:..|..:|:::..|.....|:  :.|.|.|..: .|.|.|..||.|||.
Mouse   438 NLRSKTGLGF-LQDSGLCVVADKLNFLRYLSHFRCVHRGAAFAKMRTTT-VRRLLPESWGFLCPV 500

  Fly   490 DTPEGEACGLVKNLALMTHITTE-VEERPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVL 553
            .||:|..|||:.:|..:..:.|: |....:..:....||..:......|.:  :.:.|.::|.::
Mouse   501 HTPDGAPCGLLNHLTAVCEVVTKFVYTASIPALLCGLGVTPVDTAPCRPYS--DCYPVLLDGVMV 563

  Fly   554 G-----LTLNHKHLVRNLRYMRRK--------------GRMGSYVSVHTSYTQRCIYIHTDGGRL 599
            |     |.......:|..:.:|.|              |:...|..         :::.|...||
Mouse   564 GWVDKDLAPEVADTLRRFKVLREKRIPPWMEVALIPMTGKPSLYPG---------LFLFTTPCRL 619

  Fly   600 CRPYVIVE-NRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDRTTH 663
            .||...:| .|..|:..  :::|...:..|:|.:..|:                        :||
Mouse   620 VRPVQNLELGREELIGT--MEQLFMNVAIFEDEVFGGI------------------------STH 658

  Fly   664 LEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVK 728
            .|:.|.:||.|.|..:|:..|||||||.|||.||||.||......:||.|:.:|.|..|.:|:|:
Mouse   659 QELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQNRSDNKLYRLQTPQSPLVR 723

  Fly   729 SKTIELTNFDKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQT 793
            ....:..:.|..|.|.||.|||:||:|||:|||:|:||||.:||:....|||:....:.....|.
Mouse   724 PCMYDFYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKFKQG 788

  Fly   794 FDRIMGPMKDALTNKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYT 858
            .|.::..:|.. ..:|:.|   ||.||:...|.:::...       |..:.:|...|:
Mouse   789 EDNLVFGVKPG-DPRVMQK---LDDDGLPFIGAKLEYGD-------PYYSYLNLNTGE------- 835

  Fly   859 AVPISYKGPEPSYIERVMVSAN---AEEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQE 920
            ...:.||..|...::.:.|.:|   :.:...|.|.:|..|.|.|||||:|||||||:...:...|
Mouse   836 GFVVYYKSKENCVVDNIKVCSNDMGSGKFKCICITVRIPRNPTIGDKFASRHGQKGILSRLWPAE 900

  Fly   921 DMPFNDFGICPDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAF----GGSKVEDIQAE 981
            ||||.:.|:.||::.||||||||||:|..:|.:.||:..|.|..|..|.|    ..|.:|.....
Mouse   901 DMPFTESGMMPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEM 965

  Fly   982 LERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRS 1046
            |:..|:|:.|.:..||||:|..|||.|:.|.||||:|:|||.||...|..|.:..:|.||..||:
Mouse   966 LKAAGYNFYGTERLYSGISGMELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPLGGRN 1030

  Fly  1047 REGGLRLGEMERDCLISYGASMLIMERLMISSDAFEVDVCRTCGRMAY-------CSW------- 1097
            .:||:|.||||||.|:::|.|.|:.:||...||.....:|..||.:..       .||
Mouse  1031 VQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHMCVECGSLLSPLLEKPPPSWSAMRNRK 1095

  Fly  1098 --CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKM 1132
              |..|..|..:..:|:||..:....||.:||:..|:
Mouse  1096 YNCTVCGRSDTIDTVSVPYVFRYFVAELAAMNIKVKL 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	344/1201 (29%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	342/1185 (29%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	42/172 (24%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	14/79 (18%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	6/39 (15%)
Polr1b	NP_033112.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		3/9 (33%)
		RpoB	35..1134	CDD:223163	342/1188 (29%)
		RNA_pol_B_RPB2	38..1133	CDD:238353	342/1185 (29%)
		RNA_pol_Rpb2_2	186..375	CDD:282427	44/208 (21%)
		RNA_pol_Rpa2_4	563..616	CDD:284335	8/61 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810