Protein Alignment Polr3B and polr2b

DIOPT Version :10

• Sequence 1: NP_523706.1
• Gene: Polr3B / 36289
• FlyBaseID: FBgn0004463
• Length: 1137
• Species: Drosophila melanogaster
• Sequence 2: XP_002937598.2
• Gene: polr2b / 100380205
• XenbaseID: XB-GENE-1012874
• Length: 1174
• Species: Xenopus tropicalis
• Alignment Length: 1170
• Identity: 439/1170 - (37%)
• Similarity: 684/1170 - (58%)
• Gaps: 95/1170 - (8%)

  Fly    35 WKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIV--------KANELVTSG---ADPLFYLKYLDV 88
            |.::.::...||||:|.:|||:.||.:.:::||        :|....|:|   ..|.:.||:..:
 Frog    27 WIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHTTGEVEEPPRYLLKFEQI 91

  Fly    89 RVGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYT---RGTQRI--KRNNLLIGRMPLML 148
            .:.||...:.........|:|.|||:.|||||:.|||..|   .|.::|  :.....||::|:||
 Frog    92 YLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVVKEGEEQIQTQHQKTFIGKIPIML 156

  Fly   149 RCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLT-----EDFNGVVQC 208
            |.:.|.|.|.::.:|.:||||||||||||::.|.|||::.||:::.|.:..     ..:....:|
 Frog   157 RSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTAEC 221

  Fly   209 QVTSSTHEKKSR------TLVLSKHGK---------------YYLKHNSMTDDIPIVVIFKALGV 252
            :   |..|..||      ..:|::.|:               .|:|     .::||:::|:|||.
 Frog   222 R---SCLENSSRPTSSIWVSMLARGGQGAKKSAIGQRIVATLPYIK-----QEVPIIIVFRALGF 278

  Fly   253 VSDQEIQSLIGI---DSKSQNRFGASLIDAYNLKVFTQQRALEYMGSKLVVKRFQSATTKTPSEE 314
            |||::|...|..   |.:.......||.:|:.::  .|..||.::||:   ......|.:...:.
 Frog   279 VSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQ--EQNVALNFIGSR---GAKPGVTKEKRIKY 338

  Fly   315 ARELLLTTILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMM 379
            |:|:|...:|.||.|.:|....||.::..||.|::.|.|.:...||||:||||||:|||.||:.:
 Frog   339 AKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFL 403

  Fly   380 FEDLFKRMNWELKTIADKNIPKVKAAQFDVVKHMRAAQITAGLESAISSGNW-TIKRFKMERAGV 443
            |..:||.:..|::..|.|.|.:.|  .|::...::...|:.||:.::::||| ..|:....||||
 Frog   404 FRGMFKNLLKEVRIYAQKFIDRGK--DFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGV 466

  Fly   444 TQVLSRLSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTH 508
            :|||:||::.|.|..:.|:||...:..|::.||.|..:.|||:||::||||.|.|||||||||.:
 Frog   467 SQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY 531

  Fly   509 ITTEVEERPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRK- 572
            |:...:..|::.......:|::.|:|  |....:...:|:||..:|:..:.:.|:..||.:||:
 Frog   532 ISVGSQPSPILEFLEEWSMENLEEIS--PAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM 594

  Fly   573 GRMGSYVSVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRKFD-----DFL 632
            ..:.|.||:.....:|.|.|:||.||:|||.:|||.::.|:|:.|:|:|..  |:::     |.:
 Frog   595 DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKRRHIDQLKE--REYNNYSWQDLV 657

  Fly   633 LDGLIEYLDVNEENDSFIAWNEDQIEDR-------TTHLEIEPFTLLGVCAGLVPYPHHNQSPRN 690
            ..|::||:|..||....:|...|.::::       .||.||.|..:|||||.::|:|.|||||||
 Frog   658 ASGVVEYIDTLEEETVMLAMTPDDLQEKGVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRN 722

  Fly   691 TYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSG 755
            |||.||||||||:...|...|:|:|.:.|.||..|:|.::::|...|.:||||.|:.||:.||:|
 Frog   723 TYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTG 787

  Fly   756 YDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDR---IMGPMKDALTNKVIFKHDVLD 817
            |:.||::|:|::::|||:.|.:.|::.|   ::.:.:.||:   ...|.::.........:|.||
 Frog   788 YNQEDSVIMNRSAVDRGFFRSVFYRSYK---EQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLD 849

  Fly   818 TDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAVPIS--YKGPEPSYIERVMVSAN 880
            .||::|||.:|....::|.|.:....:.:.|:..:.:  ||....|  .:..|...:::|||:.|
 Frog   850 DDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRR--YTKRDCSTFLRTSETGIVDQVMVTLN 912

  Fly   881 AEEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMT 945
            .|.....||.:|..|||:|||||:|||||||..|:...||||||...||.||:|:|||..|||||
 Frog   913 QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMT 977

  Fly   946 VGKTLELLGGKAGLLEGKFHYGTAFGGS-KVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIY 1009
            ||..:|.|.||....:|:....|.|..: .|:.|...|..:|::..|.:..|:|.||..:.:.|:
 Frog   978 VGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIF 1042

  Fly  1010 SGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERL 1074
            .||.|||:|||||.||:|:|||||..:|.|||.:||||:||||.|||||||.|::||:..:.|||
 Frog  1043 IGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERL 1107

  Fly  1075 MISSDAFEVDVCRTCGRMAYCSW------CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKMI 1133
            ..:||.::|.||..||.||..:.      |..|::...:|.:.||||||||||||.||::.|:|:
 Frog  1108 FEASDPYQVHVCNLCGLMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMM 1172

  Fly  1134  1133
             Frog  1173  1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr3B	NP_523706.1	RNA_pol_B_RPB2	47..1133	CDD:238353	435/1156 (38%)
		RNA_pol_Rpb2_4	546..607	CDD:428012	23/61 (38%)
		RNA_pol_Rpb2_5	628..668	CDD:428013	13/51 (25%)
polr2b	XP_002937598.2	Ricin_B_lectin	27..1172	CDD:481363	438/1168 (38%)