DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIII128 and polr2b

DIOPT Version :9

Sequence 1:	NP_523706.1	Gene:	RpIII128 / 36289	FlyBaseID:	FBgn0004463	Length:	1137	Species:	Drosophila melanogaster
Sequence 2:	NP_001019632.2	Gene:	polr2b / 100149268	ZFINID:	ZDB-GENE-041008-1	Length:	1174	Species:	Danio rerio

Alignment Length:	1164	Identity:	438/1164 - (37%)
Similarity:	686/1164 - (58%)	Gaps:	83/1164 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 WKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIV--------KANELVTSG---ADPLFYLKYLDV 88
            |.::.::...||||:|.:|||:.||.:.:::||        :|....|||   ..|.:.||:..:
Zfish    27 WIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHTSGEVEEPPRYLLKFEQI 91

  Fly    89 RVGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYT-----RGTQRIKRNNLLIGRMPLML 148
            .:.||...:.........|:|.|||:.|||||:.|||..|     ...|:.:.....||::|:||
Zfish    92 YLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTIIKDGEEQQQTQHQKTFIGKIPIML 156

  Fly   149 RCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLT---ED----FNGVV 206
            |.:.|.|:|.::.:|.:||||||||||||::.|.|||::.||:::.|.:..   :|    :.|
Zfish   157 RSTYCLLSGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTG-- 219

  Fly   207 QCQVTSSTHEKKSRTLVLS--KHGKYYLKHNS-----------MTDDIPIVVIFKALGVVSDQEI 258
            :|:.......:.:.|:.:|  ..|...:|.::           :..::||:::|:|||.|||::|
Zfish   220 ECRSCLENSSRPTSTIWVSMMARGGQGVKKSAIGQRIVSTLPYIRQEVPIIIVFRALGFVSDRDI 284

  Fly   259 QSLIGI---DSKSQNRFGASLIDAYNLKVFTQQRALEYMGSKLVVKRFQSATTKTPSEEARELLL 320
            ...|..   |.:.......||.:|:.::  .|..||.::||:   ......|.:...:.|:|:|.
Zfish   285 LEHIIYDFDDPEMMEMVKPSLDEAFVIQ--EQNVALNFIGSR---GAKPGVTKERRIKYAKEVLQ 344

  Fly   321 TTILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFK 385
            ..:|.||.|.:|....||.::..||.|::.|.|.:...||||:||||||:|||.||:.:|..:||
Zfish   345 KEVLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFK 409

  Fly   386 RMNWELKTIADKNIPKVKAAQFDVVKHMRAAQITAGLESAISSGNW-TIKRFKMERAGVTQVLSR 449
            .:..|::..|.|.|.:.|  .|::...::...|:.||:.::::||| .:|:....||||:|||:|
Zfish   410 NLLKEIRIYAQKFIDRGK--DFNLELAIKTRIISDGLKYSLATGNWGDVKKAHQARAGVSQVLNR 472

  Fly   450 LSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVE 514
            |::.|.|..:.||||...:..|::.||.|..:.|||:||::||||.|.|||||||||.:|:...:
Zfish   473 LTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQ 537

  Fly   515 ERPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRK-GRMGSY 578
            ..|::.......:|::.|:|  |....:...:|:||..:|:..:.:.|:..||.:||: ..:.|.
Zfish   538 PSPILEFLEEWSMENLEEIS--PAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE 600

  Fly   579 VSVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRKFD-----DFLLDGLIE 638
            ||:.....:|.|.|:||.||:|||.:|||.::.|:|:.|:|:|..  |:::     |.:..|::|
Zfish   601 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKRRHIDQLKE--REYNNYSWQDLVASGVVE 663

  Fly   639 YLDVNEENDSFIAWNEDQIEDR-------TTHLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAM 696
            |:|..||....:|...|.::::       .||.||.|..:|||||.::|:|.||||||||||.||
Zfish   664 YIDTLEEETVMLAMTPDDLQEKGVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAM 728

  Fly   697 GKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSGYDIEDA 761
            ||||||:...|...|:|:|.:.|.||..|:|.::::|...|.:||||.|:.||:.||:||:.||:
Zfish   729 GKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDS 793

  Fly   762 LILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDR---IMGPMKDALTNKVIFKHDVLDTDGIVA 823
            :|:|::::|||:.|.:.|::.|   ::.:.:.||:   ...|.::.........:|.||.||::|
Zfish   794 VIMNRSAVDRGFFRSVFYRSYK---EQESKKGFDQEEIFEKPTRETCQGMRHAIYDKLDDDGLIA 855

  Fly   824 PGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAVPIS--YKGPEPSYIERVMVSANAEEDFL 886
            ||.:|..:.::|.|.:....:.:.|...:.:  ||....|  .:..|...:::|||:.|.|....
Zfish   856 PGVRVSGEDVIIGKTVTLPENDDELDSTNRR--YTKRDCSTFLRTSETGIVDQVMVTLNQEGYKF 918

  Fly   887 IKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTVGKTLE 951
            .||.:|..|||:|||||:|||||||..|:...||||||...||.||:|:|||..|||||||..:|
Zfish   919 CKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTVGHLIE 983

  Fly   952 LLGGKAGLLEGKFHYGTAFGGS-KVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYY 1015
            .|.||....:|:....|.|..: .|:.:...|..:|::..|.:..|:|.||..|.:.|:.||.||
Zfish   984 CLQGKVSANKGEIGDATPFNDAVNVQKVSNLLSEYGYHLRGNEVLYNGFTGRKLTSQIFVGPTYY 1048

  Fly  1016 QKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDA 1080
            |:|||||.||:|:|||||..:|.|||.:||||:||||.|||||||.|::||:..:.|||..:||.
Zfish  1049 QRLKHMVDDKIHSRARGPVQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLKERLFEASDP 1113

  Fly  1081 FEVDVCRTCGRMAYCSW------CHFCQSSANVSKISMPYACKLLFQELTSMNVVPKMI 1133
            ::|.||..||.||..:.      |..|::...:|.:.||||||||||||.||::.|:|:
Zfish  1114 YQVHVCNLCGLMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMM 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIII128	NP_523706.1	PRK08565	34..1135	CDD:236291	438/1164 (38%)
		RNA_pol_B_RPB2	47..1133	CDD:238353	434/1150 (38%)
		RNA_pol_Rpb2_2	210..370	CDD:282427	49/175 (28%)
		RNA_pol_Rpb2_4	546..607	CDD:282431	23/61 (38%)
		RNA_pol_Rpb2_5	628..668	CDD:282432	13/51 (25%)
polr2b	NP_001019632.2	PRK08565	27..1172	CDD:236291	437/1162 (38%)
		RNA_pol_B_RPB2	39..1172	CDD:238353	434/1150 (38%)
		RNA_pol_Rpb2_4	567..629	CDD:282431	23/61 (38%)
		RNA_pol_Rpb2_5	653..700	CDD:282432	13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X610
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820