DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 128up and RBG1

DIOPT Version :9

Sequence 1:	NP_536733.1	Gene:	128up / 36288	FlyBaseID:	FBgn0010339	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_009364.1	Gene:	RBG1 / 851195	SGDID:	S000000034	Length:	369	Species:	Saccharomyces cerevisiae

Alignment Length:	370	Identity:	241/370 - (65%)
Similarity:	303/370 - (81%)	Gaps:	4/370 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTILEKISAIESEMARTQKNKATSAHLGLLKAKLAKLRRELI--SPKGGGGGTGEAGFEVAKTG 63
            |||.:|||.|||.||||||||||||.|||.||||||||||||:  :..|.|||.| .||:||:||
Yeast     1 MSTTVEKIKAIEDEMARTQKNKATSFHLGQLKAKLAKLRRELLTSASSGSGGGAG-IGFDVARTG 64

  Fly    64 DARVGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGCIKYKGAKIQLLDLPGIIEGAKDG 128
            .|.||||||||||||||||.|.|..||.|.||||||.||||.|:|||||||:|||||||:|||||
Yeast    65 VASVGFVGFPSVGKSTLLSKLTGTESEAAEYEFTTLVTVPGVIRYKGAKIQMLDLPGIIDGAKDG 129

  Fly   129 KGRGRQVIAVARTCNLIFMVLDCLKPLGHKKLLEHELEGFGIRLNKKPPNIYYKRKDKGGINLNS 193
            :|||:|||||||||||:|::||..|||.||:::|.||||.||||||.||:|..|:|:||||::.:
Yeast   130 RGRGKQVIAVARTCNLLFIILDVNKPLHHKQIIEKELEGVGIRLNKTPPDILIKKKEKGGISITN 194

  Fly   194 MVPQSELDTDLVKTILSEYKIHNADITLRYDATSDDLIDVIE-GNRIYIPCIYLLNKIDQISIEE 257
            .||.:.|..|.::.::|||:|::|:|..|.|||.||||||:| .:|.|:|.||:|||||.:||||
Yeast   195 TVPLTHLGNDEIRAVMSEYRINSAEIAFRCDATVDDLIDVLEASSRRYMPAIYVLNKIDSLSIEE 259

  Fly   258 LDVIYKIPHCVPISAHHHWNFDDLLELMWEYLRLQRIYTKPKGQLPDYNSPVVLHNERTSIEDFC 322
            |:::|:||:.||||:...||.|:||::||:.|.|.|||||||||:||:..||||.::|.|::|||
Yeast   260 LELLYRIPNAVPISSGQDWNLDELLQVMWDRLNLVRIYTKPKGQIPDFTDPVVLRSDRCSVKDFC 324

  Fly   323 NKLHRSIAKEFKYALVWGSSVKHQPQKVGIEHVLNDEDVVQIVKK 367
            |::|:|:..:|:.|||:|||||||||.||:.|:|.|||||.|:||
Yeast   325 NQIHKSLVDDFRNALVYGSSVKHQPQYVGLSHILEDEDVVTILKK 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
128up	NP_536733.1	Rbg1	1..367	CDD:224085	239/368 (65%)
RBG1	NP_009364.1	Rbg1	1..369	CDD:224085	239/368 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344608
Domainoid	1	1.000	162	1.000	Domainoid score	I846
eggNOG	1	0.900	-	-		E1_COG1163
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3060
Inparanoid	1	1.050	485	1.000	Inparanoid score	I218
Isobase	1	0.950	-	0	Normalized mean entropy	S98
OMA	1	1.010	-	-		QHG60797
OrthoFinder	1	1.000	-	-		FOG0001080
OrthoInspector	1	1.000	-	-		oto99672
orthoMCL	1	0.900	-	-		OOG6_102018
Panther	1	1.100	-	-	LDO	PTHR43127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1835
SonicParanoid	1	1.000	-	-		X3699
TreeFam	1	0.960	-	-
	16	15.740