DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pds5 and PDS5

DIOPT Version :9

Sequence 1:	NP_001246271.1	Gene:	pds5 / 36286	FlyBaseID:	FBgn0260012	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_013793.1	Gene:	PDS5 / 855099	SGDID:	S000004681	Length:	1277	Species:	Saccharomyces cerevisiae

Alignment Length:	1269	Identity:	256/1269 - (20%)
Similarity:	490/1269 - (38%)	Gaps:	266/1269 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LGTDELIRRLKTLANVLQTMDQDDNLYQQYIPLALHLLDDF--------FMQHPSRDVQLLIACC 73
            :.|:||:.|||.|...|.::|||:.        .|..||.:        .::|....::...|||
Yeast    23 ISTNELLDRLKALHEELASLDQDNT--------DLTGLDKYRDALVSRKLLKHKDVGIRAFTACC 79

  Fly    74 VADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFNMCFELE 138
            ::|:||:|||:|||.:. |:..|||..:.|...|.|..:....:..||:..|...:|..:..:|.
Yeast    80 LSDILRLYAPDAPYTDA-QLTDIFKLVLSQFEQLGDQENGYHIQQTYLITKLLEYRSIVLLADLP 143

  Fly   139 DCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPYKSNNKF 203
            ....:..:||. ||...|.....::.|....:|..:|:|.|::.:|:|.||.          |||
Yeast   144 SSNNLLIELFH-IFYDPNKSFPARLFNVIGGILGEVISEFDSVPLEVLRLIF----------NKF 197

  Fly   204 ACQLTEQL---LTKTGDA-------LESTIKMFFNRALVM-----------DKPNTK-LSITNKI 246
            ......::   |..|.|.       |..|.....:|.|..           |..|:: |::..|:
Yeast   198 LTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKYYSEIIHEATNDDNNSRLLTVVVKL 262

  Fly   247 YDIIYELNRINAGLLCSVLPQLENKLLSTDDAERLKATTLLSRMF-SEKDSQLAKKYPNLLKIFF 310
            :.::..|......|:.:|:..:.::|.|.::..|.:||.|:.::. |..|......:.:..|.:.
Yeast   263 HKLVLRLWETVPELINAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHSDTFKAWI 327

  Fly   311 GRFCDITEPVRIKCVQSSMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVM-----AIVE--- 367
            .:..||:..||::..:|....:.....:..::.:.|.....|.|..||...||     .:.|
Yeast   328 SKIADISPDVRVEWTESIPQIIATREDISKELNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWK 392

  Fly   368 --TAKRDFTLVLEAPDLLEIVRERTLDKKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVR---- 426
              |.|..:|      .||.:.||    |..::|...:|.:|..|..::   |::....:.:
Yeast   393 NITNKAIYT------SLLHLARE----KHKEVRELCINTMAKFYSNSL---NEIERTYQNKEIWE 444

  Fly   427 -VDWIKNKILHGYYKVGLEDRLLVERLLITCLVPYKLAPEERMKKLYHLLGDLDANATKAFVELQ 490
             :|.|.:.:.:.||...|.....|:.::...|:|::...::|:.:|..:|...|..|..:|....
Yeast   445 IIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLPFEPDNDKRVHRLLTVLSHFDKKAFTSFFAFN 509

  Fly   491 KNQMKTRNTVSDWIK----LHHSKEFT----PRVLSQLSAKQANIAKLLPDPLK---AAEYLTQF 544
            ..|:|....:|.:|.    |::.:..:    |.|:::.:.....:|..|.|..|   |.|.:.||
Yeast   510 ARQIKISFAISKYIDFSKFLNNQESMSSSQGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQF 574

  Fly   545 SNNLRKDAQLLRCINIVLKRDV---SCREC-------ADTMGVLLK---KLGAHVQSNLYYNTVK 596
            :     |.::...:|..:..|:   :.:.|       ..|.|:..|   ..||.:........::
Yeast   575 N-----DERIFYLLNACVTNDIPFLTFKNCYNELVSKLQTPGLFKKYNISTGASIMPRDIAKVIQ 634

  Fly   597 MLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAMLSYVFSAHFFTD 661
            :|:.|.:.::.:..:|.||::|     ...|..:::.:..        ::|..:|.| :...|.|
Yeast   635 ILLFRASPIIYNVSNISVLLNL-----SNNSDAKQLDLKR--------RILDDISKV-NPTLFKD 685

  Fly   662 TSLRHLISL--------------LSYEQDYVAPLVLKTLTHLGR-YQPLIDDPTPAILDELAPVC 711
             .:|.|.::              ||.|:      .||||....: .:..:|........:|
Yeast   686 -QIRTLKTIIKDLDDPDAEKNDNLSLEE------ALKTLYKASKTLKDQVDFDDTFFFTKL---- 739

  Fly   712 KDFALIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFNEIIETLRLKLTPNC 776
            .|||:...|:..|:|.:.|                         .:.|...|.::.:::::.| .
Yeast   740 YDFAVESKPEITKYATKLI-------------------------ALSPKAEETLKKIKIRILP-L 778

  Fly   777 EHQRTK-----IVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQEVPAQRDYELPEDSDWCAQE 836
            :.|:.|     |:.|..|....|........::|:..|.:.||..:|......|:    || .::
Yeast   779 DLQKDKYFTSHIIVLMEIFKKFPHVLNDDSTDIISYLIKEVLLSNQVVGDSKKEI----DW-VED 838

  Fly   837 KLPPDTLC-----KLDALKAMARWLLGLRTD-------EHAAQKTFRMLAAFVNQRGDLLGQ-NR 888
            .|..||..     |:..||.....|..:..|       |...:||.::....:...|:|:.: |:
Yeast   839 SLLSDTKYSAIGNKVFTLKLFTNKLRSIAPDVPRDELAESFTEKTMKLFFYLIASGGELISEFNK 903

  Fly   889 ----LCGAEKSWLRLGAACAMLKVCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGL 949
                .....::.||..|...:||:.....:.:.......::|..|:.|....||:.|..:|...:
Yeast   904 EFYPTPSNYQTKLRCVAGIQVLKLARISNLNNFIKPSDIIKLINLVEDESLPVRKTFLEQLKDYV 968

  Fly   950 SRSLPRNCLPLDFMGLYVLAGLETERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLH 1014
            :..|    :.:.|:.|......|.:.:|:...:.:...          |..:.|....|
Yeast   969 ANEL----ISIKFLPLVFFTAYEPDVELKTTTKIWINF----------TFGLKSFKKGT------ 1013

  Fly  1015 ILPDYMLAFAIPVLVHDPRFTNHEDYV---------QLRKMEKCLRFIL--EPLMAKRETFVHSF 1068
                 :...|:|.|:|  ...:|.|.|         .|..:...:.::|  ...:|.:|.|...:
Yeast  1014 -----IFERALPRLIH--AIAHHPDIVGGLDSEGDAYLNALTTAIDYLLFYFDSIAAQENFSLLY 1071

  Fly  1069 YKQLLQLIKHREFSLGSDKRD-----------------NYKMWALCDLAMYIIDSKFSPFDGNTS 1116
            |  |.:.:|:.:..|..|:.|                 ..||:.:.:|:..|:.:.....:...|
Yeast  1072 Y--LSERVKNYQDKLVEDEIDEEEGPQKEEAPKKHRPYGQKMYIIGELSQMILLNLKEKKNWQHS 1134

  Fly  1117 TFSMPLALPEMYYK-----EPAVANFQNNDVYIP 1145
            .:...|.||...:|     :.|..:|:   .|||
Yeast  1135 AYPGKLNLPSDLFKPFATVQEAQLSFK---TYIP 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pds5	NP_001246271.1	None
PDS5	NP_013793.1	PDS5	28..680	CDD:410996	151/703 (21%)
		HEAT repeat	229..274	CDD:410996	7/44 (16%)
		HEAT repeat	275..307	CDD:410996	8/31 (26%)
		HEAT repeat	276..308	CDD:293787	8/31 (26%)
		HEAT repeat	321..349	CDD:410996	6/27 (22%)
		HEAT repeat	321..349	CDD:293787	6/27 (22%)
		HEAT repeat	354..388	CDD:410996	7/33 (21%)
		HEAT repeat	358..384	CDD:293787	7/25 (28%)
		HEAT repeat	396..425	CDD:293787	10/38 (26%)
		HEAT repeat	399..430	CDD:410996	10/40 (25%)
		HEAT repeat	445..478	CDD:410996	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41001
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55449
OrthoFinder	1	1.000	-	-		FOG0001888
OrthoInspector	1	1.000	-	-		oto99308
orthoMCL	1	0.900	-	-		OOG6_101478
Panther	1	1.100	-	-	LDO	PTHR12663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3128
SonicParanoid	1	1.000	-	-		X1823
TreeFam	0	0.000	Not matched by this tool.
	12	11.780