Protein Alignment pds5 and Pds5a

DIOPT Version :9

• Sequence 1: NP_001246271.1
• Gene: pds5 / 36286
• FlyBaseID: FBgn0260012
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_006504178.1
• Gene: Pds5a / 71521
• MGIID: 1918771
• Length: 1333
• Species: Mus musculus
• Alignment Length: 1237
• Identity: 454/1237 - (36%)
• Similarity: 701/1237 - (56%)
• Gaps: 93/1237 - (7%)

  Fly     4 IVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQD-DNLYQQYIPLALHLLDDFFMQHPSRDVQ 67
            |.||.|.:.:.:.:.|||:|:|||.:......|||| ::..|||:||||||..:||:::|::||:
Mouse    22 IAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVR 86

  Fly    68 LLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFN 132
            ||:|||:||:.|:|||||||...|::|.||.|..:||.||:|.:.|.|.||||||||||:|||:|
Mouse    87 LLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYN 151

  Fly   133 MCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPY 197
            :|||||||.|||..||.|:|.::|:.|:.||....||::|.:|.|.|.::.||||.||||::..:
Mouse   152 ICFELEDCNEIFIQLFRTLFSVINNSHNTKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAH 216

  Fly   198 KSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLSITNKIYDIIYELNRINAGLLC 262
            |:.||.:..|.:.||.:|...:|:.|..|||:.||:.:.:.. .::..::|:|.||..|:..||.
Mouse   217 KNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVS-DLSEHVFDLIQELFAIDPQLLL 280

  Fly   263 SVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQS 327
            ||:||||.||.|.|..|||....||:::|..|||.||.:...|.:.|.|||.||..|||::.|:.
Mouse   281 SVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKF 345

  Fly   328 SMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTLD 392
            :.|.|:|||.|..|:||.|::|:||.:|.:||:|::.|:..||||..||.:  .||..|||||||
Mouse   346 ASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVND--QLLGFVRERTLD 408

  Fly   393 KKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITCL 457
            |::::|::||.|||.:||: .|...:.......:|.|||:|:||.||:..::|:||||::....|
Mouse   409 KRWRVRKEAMMGLAQLYKK-YCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYL 472

  Fly   458 VPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRV-LSQLS 521
            ||:.|..|||||.||:|...||.||.||..|:.|.|...|:.|.:.:.||  |:.|... .|.:.
Mouse   473 VPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLH--KQPTSEANCSAMF 535

  Fly   522 AKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHV 586
            .|...|||.||||.||.:::.:|:..|..|.:|...:.:::....||::....:..:.:||....
Mouse   536 GKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADVCVREIARKLANPK 600

  Fly   587 Q-SNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAML 650
            | :|.:...||.|:||:|.|.:|.|:|..|:.|:.:.||..:..||.|:|...|...||:||.:|
Mouse   601 QPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVL 665

  Fly   651 SYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFA 715
            |:.....|.:..:...|:..|..|.|.||...::...:.|.   .|:...|.|...|.|:....|
Mouse   666 SFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGH---KIETDLPQIRSTLIPILHQKA 727

  Fly   716 LIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFN-------EIIETLRLKLT 773
            ..|||.|||.||.||                           |.||:       :|.|.|...|.
Mouse   728 KRGTPHQAKQAVHCI---------------------------HAIFSNKEVQLAQIFEPLSRSLN 765

  Fly   774 PNCEHQR-TKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQE-VPAQRDYELPEDSDWCAQE 836
            .:...|. |.:|:||||:...|..|.:|:|:::|..|||:||:.: ...:::.:|     |...|
Mouse   766 ADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKL-----WSPDE 825

  Fly   837 KLPPDTLCKLDALKAMARWLLGLRTDE-HAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLG 900
            ::.|:.|.|:.|:|.:.|||||::.:: .:|..|.|:|:|.:...|||..|.|:..::.|.|||.
Mouse   826 EVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLA 890

  Fly   901 AACAMLKVCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGL 965
            |..|::|:.::....:..:.||:...:.::.|...:||:|||:||||.|.:.|    |||::|.:
Mouse   891 AGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLL----LPLEYMAI 951

  Fly   966 YVLAGLETERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVH 1030
            :.|...:..::.:...|.....:::.||||:|...|     :|| :.|.:||:|::.:.|.:|.|
Mouse   952 FALCAKDPVKERRAHARQCLLKNISIRREYIKQNPM-----ATE-KLLSLLPEYVVPYMIHLLAH 1010

  Fly  1031 DPRFTNHEDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIK-HREFSLGSDKRDNYKMW 1094
            ||.||..:|..|||.:::||.|:||.||.|.|...|:|.|::.:.|| .|:.....:.:.|.|::
Mouse  1011 DPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLY 1075

  Fly  1095 ALCDLAMYIIDSKF------SPFDGNTSTFSMPLALPEMYYKEPAVANFQNNDVYIPLDVYTLGA 1153
            .:||:|:.:|:||.      ||.|        |: ||..::.:|. .:|.|:..||..:...|..
Mouse  1076 TVCDVALCVINSKSALCNADSPKD--------PV-LPMKFFTQPE-KDFCNDKSYISEETRVLLL 1130

  Fly  1154 KSTSKAAATAMTTSRAAVAP-KRPAEQSIMDDENPQENNLFDNIRAADTTEPMA----KRTRAGA 1213
            ....|......|.::...|. ::|..:|...:..       .||.|.....|.|    .|.::..
Mouse  1131 TGKPKPTGVLGTVNKPLSATGRKPYVRSAGTETG-------SNINANSELSPSAGSRSSREQSSE 1188

  Fly  1214 AS 1215
            ||
Mouse  1189 AS 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pds5	NP_001246271.1	None
Pds5a	XP_006504178.1	HEAT repeat	282..312	CDD:293787	15/29 (52%)
		HEAT repeat	322..348	CDD:293787	11/25 (44%)
		HEAT repeat	359..385	CDD:293787	12/25 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841003
Domainoid	1	1.000	743	1.000	Domainoid score	I93
eggNOG	1	0.900	-	-		E1_KOG1525
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	747	1.000	Inparanoid score	I580
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55449
OrthoDB	1	1.010	-	-		D56082at33208
OrthoFinder	1	1.000	-	-		FOG0001888
OrthoInspector	1	1.000	-	-		otm42930
orthoMCL	1	0.900	-	-		OOG6_101478
Panther	1	1.100	-	-	LDO	PTHR12663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3128
SonicParanoid	1	1.000	-	-		X1823
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800