DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pds5 and Pds5a

DIOPT Version :9

Sequence 1:	NP_001246271.1	Gene:	pds5 / 36286	FlyBaseID:	FBgn0260012	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_038947845.1	Gene:	Pds5a / 305343	RGDID:	1307094	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	1237	Identity:	454/1237 - (36%)
Similarity:	702/1237 - (56%)	Gaps:	93/1237 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQD-DNLYQQYIPLALHLLDDFFMQHPSRDVQ 67
            |.||.|.:.:.:.:.|||:|:|||.:......|||| ::..|||:||||||..:||:::|::||:
  Rat    22 IAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVR 86

  Fly    68 LLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFN 132
            ||:|||:||:.|:|||||||...|::|.||.|..:||.||:|.:.|.|.||||||||||:|||:|
  Rat    87 LLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYN 151

  Fly   133 MCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPY 197
            :|||||||.|||..||.|:|.::|:.|:.||....||::|.:|.|.|.::.||||.||||::..:
  Rat   152 ICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAH 216

  Fly   198 KSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLSITNKIYDIIYELNRINAGLLC 262
            |:.||.:..|.:.||.:|...:|:.|..|||:.||:.:.:.. .::..::|:|.||..|:..||.
  Rat   217 KNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVS-DLSEHVFDLIQELFAIDPHLLL 280

  Fly   263 SVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQS 327
            ||:||||.||.|.|..|||....||:::|..|||.||.:...|.:.|.|||.||..|||::.|:.
  Rat   281 SVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKF 345

  Fly   328 SMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTLD 392
            :.|.|:|||.|..|:||.|::|:||.:|.:||:|::.|:..||||..||.:  .||..|||||||
  Rat   346 ASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVND--QLLGFVRERTLD 408

  Fly   393 KKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITCL 457
            |::::|::||.|||.:||: .|...:.......:|.|||:|:||.||:..::|:||||::....|
  Rat   409 KRWRVRKEAMMGLAQLYKK-YCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYL 472

  Fly   458 VPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRV-LSQLS 521
            ||:.|..|||||.||:|...||.||.||..|:.|.|...|:.|.:.:.||  |:.|... .|.:.
  Rat   473 VPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLH--KQPTSEANCSAMF 535

  Fly   522 AKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHV 586
            .|...|||.||||.||.:::.:|:..|..|.:|...:.:::....||::....:..:.:||....
  Rat   536 GKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPK 600

  Fly   587 Q-SNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAML 650
            | :|.:...||.|:||:|.|.:|.|:|..|:.|:.:.||..:..||.|:|...|...||:||.:|
  Rat   601 QPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVL 665

  Fly   651 SYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFA 715
            |:.....|.:..:...|:..|..|.|.||...::...:.|.   .|:...|.|...|.|:....|
  Rat   666 SFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGH---KIETDLPQIRSTLIPILHQKA 727

  Fly   716 LIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFN-------EIIETLRLKLT 773
            ..|||.|||.||.||                           |.||:       :|.|.|...|.
  Rat   728 KRGTPHQAKQAVHCI---------------------------HAIFSNKEVQLAQIFEPLSRSLN 765

  Fly   774 PNCEHQR-TKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQE-VPAQRDYELPEDSDWCAQE 836
            .:...|. |.:|:||||:...|..|.:|:|:::|..|||:||:.: ...:::.:|     |...|
  Rat   766 ADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKL-----WSPDE 825

  Fly   837 KLPPDTLCKLDALKAMARWLLGLRTDE-HAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLG 900
            ::.|:.|.|:.|:|.:.|||||::.:: .:|..|.|:|:|.:...|||..|.|:..::.|.|||.
  Rat   826 EVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLA 890

  Fly   901 AACAMLKVCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGL 965
            |..|::|:.::....:..:.||:...:.::.|...:||:|||:||||.|.:.|    |||::|.:
  Rat   891 AGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLL----LPLEYMAI 951

  Fly   966 YVLAGLETERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVH 1030
            :.|...:..::.:...|.....:::.||||:|...|     :|| :.|.:||:|::.:.|.:|.|
  Rat   952 FALCAKDPVKERRAHARQCLLKNISIRREYIKQNPM-----ATE-KLLSLLPEYVVPYMIHLLAH 1010

  Fly  1031 DPRFTNHEDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIK-HREFSLGSDKRDNYKMW 1094
            ||.||..:|..|||.:::||.|:||.||.|.|...|:|.|::.:.|| .|:.....:.:.|.|::
  Rat  1011 DPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDEAKTNEKLY 1075

  Fly  1095 ALCDLAMYIIDSKF------SPFDGNTSTFSMPLALPEMYYKEPAVANFQNNDVYIPLDVYTLGA 1153
            .:||:|:.:|:||.      ||.|        |: ||..::.:|. .:|.|:..||..:...|..
  Rat  1076 TVCDVALCVINSKSALCNADSPKD--------PV-LPMKFFTQPE-KDFSNDKSYISEETRVLLL 1130

  Fly  1154 KSTSKAAATAMTTSRAAVAP-KRPAEQSIMDDENPQENNLFDNIRAADTTEPMA----KRTRAGA 1213
            ....|......|.::...|. ::|..:|...:..       .||.|:....|.|    .|.::..
  Rat  1131 TGKPKPTGVLGTVNKPLSATGRKPYVRSAGTETG-------SNINASSELSPSAGNRSSREQSSE 1188

  Fly  1214 AS 1215
            ||
  Rat  1189 AS 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pds5	NP_001246271.1	None
Pds5a	XP_038947845.1	PDS5	40..670	CDD:410996	278/635 (44%)
		HEAT repeat	236..276	CDD:410996	12/40 (30%)
		HEAT repeat	277..309	CDD:410996	17/31 (55%)
		HEAT repeat	282..312	CDD:293787	15/29 (52%)
		HEAT repeat	322..350	CDD:410996	12/27 (44%)
		HEAT repeat	322..348	CDD:293787	11/25 (44%)
		HEAT repeat	355..389	CDD:410996	14/33 (42%)
		HEAT repeat	359..385	CDD:293787	12/25 (48%)
		HEAT repeat	398..429	CDD:410996	18/31 (58%)
		HEAT repeat	441..474	CDD:410996	15/32 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344422
Domainoid	1	1.000	739	1.000	Domainoid score	I92
eggNOG	1	0.900	-	-		E1_KOG1525
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	745	1.000	Inparanoid score	I554
OMA	1	1.010	-	-		QHG55449
OrthoDB	1	1.010	-	-		D56082at33208
OrthoFinder	1	1.000	-	-		FOG0001888
OrthoInspector	1	1.000	-	-		otm44999
orthoMCL	1	0.900	-	-		OOG6_101478
Panther	1	1.100	-	-	LDO	PTHR12663
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1823
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770