DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pds5 and PDS5A

DIOPT Version :9

Sequence 1:NP_001246271.1 Gene:pds5 / 36286 FlyBaseID:FBgn0260012 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_001093869.1 Gene:PDS5A / 23244 HGNCID:29088 Length:1337 Species:Homo sapiens


Alignment Length:1240 Identity:453/1240 - (36%)
Similarity:698/1240 - (56%) Gaps:117/1240 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQD-DNLYQQYIPLALHLLDDFFMQHPSRDVQ 67
            |.||.|.:.:.:.:.|||:|:|||.:......|||| ::..|||:||||||..:||:::|::||:
Human    23 IAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVR 87

  Fly    68 LLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFN 132
            ||:|||:||:.|:|||||||...|::|.||.|..:||.||:|.:.|.|.||||||||||:|||:|
Human    88 LLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYN 152

  Fly   133 MCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPY 197
            :|||||||.|||..||.|:|.::|:.|:.||....||::|.:|.|.|.::.||||.||||::..:
Human   153 ICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAH 217

  Fly   198 KSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLSITNKIYDIIYELNRINAGLLC 262
            |:.||.:..|.:.||.:|...:|:.|..|||:.||:.:.:.. .::..::|:|.||..|:..||.
Human   218 KNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVS-DLSEHVFDLIQELFAIDPHLLL 281

  Fly   263 SVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQS 327
            ||:||||.||.|.|..|||....||:::|..|||.||.:...|.:.|.|||.||..|||::.|:.
Human   282 SVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKF 346

  Fly   328 SMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTLD 392
            :.|.|:|||.|..|:||.|::|:||.:|.:||:|::.|:..||||..||.:  .||..|||||||
Human   347 ASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVND--QLLGFVRERTLD 409

  Fly   393 KKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITCL 457
            |::::|::||.|||.:||: .|...:.......:|.|||:|:||.||:..::|:||||::....|
Human   410 KRWRVRKEAMMGLAQLYKK-YCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYL 473

  Fly   458 VPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRV-LSQLS 521
            ||:.|..|||||.||:|...||.||.||..|:.|.|...|:.|.:.:.||  |:.|... .|.:.
Human   474 VPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLH--KQPTSEANCSAMF 536

  Fly   522 AKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHV 586
            .|...|||.||||.||.:::.:|:..|..|.:|...:.:::....||::....:..:.:||....
Human   537 GKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPK 601

  Fly   587 Q-SNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAML 650
            | :|.:...||.|:||:|.|.:|.|:|..|:.|:.:.||..:..||.|:|...|...||:||.:|
Human   602 QPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDTAIRSGLELLKVL 666

  Fly   651 SYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFA 715
            |:.....|.:..:...|:..|..|.|.||...::...:.|.   .|:...|.|...|.|:....|
Human   667 SFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGH---KIETDLPQIRSTLIPILHQKA 728

  Fly   716 LIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFN-------EIIETLRLKLT 773
            ..|||.|||.||.||                           |.||.       :|.|.|...|.
Human   729 KRGTPHQAKQAVHCI---------------------------HAIFTNKEVQLAQIFEPLSRSLN 766

  Fly   774 PNCEHQR-TKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQE-VPAQRDYELPEDSDWCAQE 836
            .:...|. |.:|:||||:...|..|.:|:|:::|..|||:||:.: ...:::.:|     |...|
Human   767 ADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKL-----WSPDE 826

  Fly   837 KLPPDTLCKLDALKAMARWLLGLRTDE-HAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLG 900
            ::.|:.|.|:.|:|.:.|||||::.:: .:|..|.|:|:|.:...|||..|.|:..::.|.|||.
Human   827 EVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLA 891

  Fly   901 AACAMLKVCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGL 965
            |..|::|:.::....:..:.||:...:.::.|...:||:|||:||||.|.:.|    |||::|.:
Human   892 AGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLL----LPLEYMAI 952

  Fly   966 YVLAGLETERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVH 1030
            :.|...:..::.:...|.....:::.||||:|...|     :|| :.|.:||:|::.:.|.:|.|
Human   953 FALCAKDPVKERRAHARQCLLKNISIRREYIKQNPM-----ATE-KLLSLLPEYVVPYMIHLLAH 1011

  Fly  1031 DPRFTNHEDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIK-HREFSLGSDKRDNYKMW 1094
            ||.||..:|..|||.:::||.|:||.||.|.|...|:|.|::.:.|| .|:.....:.:.|.|::
Human  1012 DPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLY 1076

  Fly  1095 ALCDLAMYIIDSKF------SPFDGNTSTFSMPLALPEMYYKEPAVANFQNNDVYI--------- 1144
            .:||:|:.:|:||.      ||.|        |: ||..::.:|. .:|.|:..||         
Human  1077 TVCDVALCVINSKSALCNADSPKD--------PV-LPMKFFTQPE-KDFCNDKSYISEETRVLLL 1131

  Fly  1145 ---PLDVYTLGA--------------KSTSKAAATAM---------TTSRAAVAPKRPAEQSIMD 1183
               |.....|||              :||.....:.:         |.:|:.......||..:.:
Human  1132 TGKPKPAGVLGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSE 1196

  Fly  1184 -DENP 1187
             :|||
Human  1197 NEENP 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pds5NP_001246271.1 None
PDS5ANP_001093869.1 PDS5 41..671 CDD:410996 278/635 (44%)
HEAT repeat 237..277 CDD:410996 12/40 (30%)
HEAT repeat 278..310 CDD:410996 17/31 (55%)
HEAT repeat 283..313 CDD:293787 15/29 (52%)
HEAT repeat 323..351 CDD:410996 12/27 (44%)
HEAT repeat 323..349 CDD:293787 11/25 (44%)
HEAT repeat 356..390 CDD:410996 14/33 (42%)
HEAT repeat 360..386 CDD:293787 12/25 (48%)
HEAT. /evidence=ECO:0000255 393..429 20/38 (53%)
HEAT repeat 399..430 CDD:410996 18/31 (58%)
HEAT repeat 442..475 CDD:410996 15/32 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1337 9/52 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150894
Domainoid 1 1.000 749 1.000 Domainoid score I93
eggNOG 1 0.900 - - E1_KOG1525
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 750 1.000 Inparanoid score I578
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55449
OrthoDB 1 1.010 - - D56082at33208
OrthoFinder 1 1.000 - - FOG0001888
OrthoInspector 1 1.000 - - otm40858
orthoMCL 1 0.900 - - OOG6_101478
Panther 1 1.100 - - LDO PTHR12663
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1823
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.770

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