DRSC/TRiP Functional Genomics Resources

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Protein Alignment pds5 and PDS5B

DIOPT Version :9

Sequence 1:NP_001246271.1 Gene:pds5 / 36286 FlyBaseID:FBgn0260012 Length:1218 Species:Drosophila melanogaster
Sequence 2:XP_005266355.1 Gene:PDS5B / 23047 HGNCID:20418 Length:1448 Species:Homo sapiens


Alignment Length:1190 Identity:445/1190 - (37%)
Similarity:695/1190 - (58%) Gaps:79/1190 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQDDNLYQQ-YIPLALHLLDDFFMQHPSRDVQ 67
            |.||.|.:.:.:.:..:|::||||.:......||||....:: |:.|||||..|||::||.:||:
Human    13 ITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVR 77

  Fly    68 LLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFN 132
            ||:|||:||:.|:|||||||...|::|.||.|..:||.||:|.:.|.|.||||||||:|:|||:|
Human    78 LLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYN 142

  Fly   133 MCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPY 197
            :||||||..|||..|:.|:|.::|:.|:.||....:|::|.:|.|.|.:|.||||.:|:|:|..:
Human   143 ICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAH 207

  Fly   198 KSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLS-ITNKIYDIIYELNRINAGLL 261
            |:.||.|..|.:.||.:|..|:|..|..|||:.|::.|  |.:| ::..::|:|.||..|::.||
Human   208 KNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGK--TSISDLSEHVFDLILELYNIDSHLL 270

  Fly   262 CSVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQ 326
            .|||||||.||.|.|:.|||:...||::||..|||:||.:...|.:.:.|||.||..|:|::||:
Human   271 LSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVK 335

  Fly   327 SSMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTL 391
            .:.|.|:|||.|..|:||.|::|:||.:|.:||:|:::||..||:|..||.:  .||..||||||
Human   336 FASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVND--HLLNFVRERTL 398

  Fly   392 DKKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITC 456
            ||::::|::||.|||.|||:...:........| ::.|||:|:||.||:..::|||||||:....
Human   399 DKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAK-QIAWIKDKLLHIYYQNSIDDRLLVERIFAQY 462

  Fly   457 LVPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRVLSQLS 521
            :||:.|...||||.||:|...||.||.||..|:.|.|...|:.|.|.:.|....: |...:..:.
Human   463 MVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPK-TDASVKAIF 526

  Fly   522 AKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHV 586
            :|...|.:.||||.||.:::.:|:..|..|.::.:.:.:::....||::....:..:.||||...
Human   527 SKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEVLVSPTCSCKQAEGCVREITKKLGNPK 591

  Fly   587 Q-SNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAML 650
            | :|.:...:|.|:||:|.|.:|.|||..||..:.:.|:..:..|:.|:...:|...||:||.:|
Human   592 QPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVL 656

  Fly   651 SYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFA 715
            |:.....|.:..:...|::.|..:.:.||...|:...:.|   ..|::..|.|...|.||....:
Human   657 SFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTG---SKIEEDFPHIRSALLPVLHHKS 718

  Fly   716 LIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFNEIIETLRLKLTP-NCEHQ 779
            ..|.|:|||:|:.||.               |..:|..||     |.:|.|.|...|.| |.||.
Human   719 KKGPPRQAKYAIHCIH---------------AIFSSKETQ-----FAQIFEPLHKSLDPSNLEHL 763

  Fly   780 RTKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQE-VPAQRDYELPEDSDWCAQEKLPPDTL 843
            .|.:||:||||...|..|..|:|:::|..|||:||:.: :|.::..:|     |...|::.|:|:
Human   764 ITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKL-----WVPDEEVSPETM 823

  Fly   844 CKLDALKAMARWLLGLRTD-EHAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLGAACAMLK 907
            .|:.|:|.|.|||||::.: ..:...|.|:|...::..|||..|.::...:.|.|||.|..|::|
Human   824 VKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVK 888

  Fly   908 VCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGLYVLAGLE 972
            :.::....:..:.|||...:..:.|...:||::||:||||||||..    |||::|.:..|...:
Human   889 LAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLR----LPLEYMAICALCAKD 949

  Fly   973 TERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVHDPRFTNH 1037
            ..::.:...|.....::|.||||||..|..|      .:.|.:||:|::.:.|.:|.|||.:...
Human   950 PVKERRAHARQCLVKNINVRREYLKQHAAVS------EKLLSLLPEYVVPYTIHLLAHDPDYVKV 1008

  Fly  1038 EDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIKHREFSLG-SDKRDNYKMWALCDLAM 1101
            :|..||:.:::||.|:||.||||.|...|:|.:::::.||..:.:.| .|.:.|.|::.:||:||
Human  1009 QDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDAKMNEKLYTVCDVAM 1073

  Fly  1102 YIIDSKFSPFDGNTSTFSM-----PLALPEMYYKEPAVANFQNNDVYIPLDVYT----------- 1150
            .||.||       ::|:|:     |: ||..::.:|. .||.|...|:|.::.:           
Human  1074 NIIMSK-------STTYSLESPKDPV-LPARFFTQPD-KNFSNTKNYLPPEMKSFFTPGKPKTTN 1129

  Fly  1151 -LGA--KSTSKAAATAMTTS 1167
             |||  |..|.|...:.|.|
Human  1130 VLGAVNKPLSSAGKQSQTKS 1149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pds5NP_001246271.1 None
PDS5BXP_005266355.1 PDS5 31..661 CDD:410996 272/635 (43%)
HEAT repeat 227..267 CDD:410996 15/41 (37%)
HEAT repeat 240..261 CDD:293787 6/22 (27%)
HEAT repeat 268..300 CDD:410996 18/31 (58%)
HEAT repeat 273..303 CDD:293787 17/29 (59%)
HEAT repeat 313..341 CDD:410996 11/27 (41%)
HEAT repeat 313..339 CDD:293787 10/25 (40%)
HEAT repeat 346..380 CDD:410996 15/33 (45%)
HEAT repeat 350..376 CDD:293787 12/25 (48%)
HEAT repeat 389..420 CDD:410996 19/30 (63%)
HEAT repeat 432..465 CDD:410996 15/32 (47%)
PTZ00449 <1042..1295 CDD:185628 33/117 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150895
Domainoid 1 1.000 749 1.000 Domainoid score I93
eggNOG 1 0.900 - - E1_KOG1525
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41001
Inparanoid 1 1.050 750 1.000 Inparanoid score I578
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55449
OrthoDB 1 1.010 - - D56082at33208
OrthoFinder 1 1.000 - - FOG0001888
OrthoInspector 1 1.000 - - otm40858
orthoMCL 1 0.900 - - OOG6_101478
Panther 1 1.100 - - O PTHR12663
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3128
SonicParanoid 1 1.000 - - X1823
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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