DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pds5 and evl-14

DIOPT Version :9

Sequence 1:	NP_001246271.1	Gene:	pds5 / 36286	FlyBaseID:	FBgn0260012	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_497865.2	Gene:	evl-14 / 175555	WormBaseID:	WBGene00001352	Length:	1570	Species:	Caenorhabditis elegans

Alignment Length:	1452	Identity:	293/1452 - (20%)
Similarity:	550/1452 - (37%)	Gaps:	360/1452 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DIVYPTGCRPLVEDLGTDELIRRLKTLANVL---QTMDQDD-NLYQQYIPLALHLLDDFFMQHPS 63
            |:.||.||.|::......:.|.||:.|.|.|   :|.:.:: :...::..|..||..:.|:.:.:
Worm     4 DVDYPQGCLPILNSNNVTQQIERLRKLFNCLHDCKTNNSEEVSSPNRFARLFQHLSQECFLDNSN 68

  Fly    64 RDVQLLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKD--PRDPSFKRYFYLLENLA 126
            .|.::|::.|:|::||::.||.|......:|.::.:..:.:.||.|  ...|.||.||.|:|.:.
Worm    69 TDFRILLSLCLANILRIFQPELPTPSVMDLKEVYIYLFRTMRGLGDVTQDSPKFKNYFSLVETME 133

  Fly   127 FVKSFNMCFELEDCQE-----IFQDLFSTIFKI--------------------VNDQHSV----- 161
              |......|::|..:     :|:.|...|..|                    .||..|:
Worm   134 --KIIPPIIEMKDHDDKEATPVFRALIKDILAIPCGKGWNQNLKKEARLLKIQENDDDSMNDDEE 196

  Fly   162 ------KVTNFFLDVLSPLITEADNLSVELLDLILINIVEPYKSNNKFACQLTEQLL----TKTG 216
                  |:....:.:.:.:||..|.:..|.||::..:|:.|.:||...|..|.|.::    ....
Worm   197 DENAAEKIRKSLIQIATTVITNLDFVQNECLDVLFYHIINPQRSNFAEARALAEDIIRSCSDNES 261

  Fly   217 DALESTIKMFFNRALVMDKPNTKLSIT-----NKIYDIIYELNRINAGLLCSVLPQLENKLLSTD 276
            |.|.::|:.....|....|...:..:|     :|.::::..|:.::..|:...:.:|:..|.|.:
Worm   262 DTLANSIRSTMTAAAKEGKLPEEFELTGSSNRSKFFEVLRYLHYVSFDLVSGAIQELKFWLQSEN 326

  Fly   277 DAERLKATTLLSRMFSEKDSQLAKKYPN-LLKIFFGRFCDITEPVRIKCVQSSMHFLL-NHPSLQ 339
            :..|.:|.|::..:..:|..|......: ....|.....|..:.||.:.||.|...|: ||..|:
Worm   327 EQYRKEAVTVVGMLTRDKHCQFGMDSNDPTWSAFLNASIDQDDSVRHEFVQQSKDILISNHSHLR 391

  Fly   340 HDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTLDKKYKIRRDAMNG 404
            ..|...|...:.||::.:|.:||..:.|.||....::  :..:|:...||..|||.|:|..|:..
Worm   392 GQIINSLLRLSVDLNDDIRRDVVTGVTEVAKTKLEVI--SDKMLKACAERMKDKKPKVRIQAIKR 454

  Fly   405 LAYIY-------------KRAICEPND-------LSTGLKVRVDWIKNKILHGY--------YKV 441
            |..:|             |...|.|.|       .:...|..|.:|...:.:.|        |.
Worm   455 LMDLYNHVMTSSPQPFFSKDGSCAPKDSKEATLSYTESEKESVRFISTAVFNVYRLTQRLPAYH- 518

  Fly   442 GLEDRLLVERLLITCLVPYKLAPEERMKKLYHLLGDLDANATKAFVEL--QKNQMKTRNTVSDWI 504
              :.|.::||.....|||||:.|:.|::.:..|..:||......|.::  :.:|:: |..:....
Worm   519 --DARAIIERYFQLYLVPYKVEPKLRVRLMADLFRNLDDIGCMLFGDIINRSSQLR-RAMIGILS 580

  Fly   505 KLHHSKEFTPRVLSQLSAKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCR 569
            ::....|.|.:..:||..:...|.::.||.....:.:..|.|.:.::.:....:..::....:..
Worm   581 QVGQFTEMTTQSSAQLKERIRRICQIFPDAQILEKNMMVFVNQMAENDETFNLVKKLMSESYTSE 645

  Fly   570 ECADTMG----VLLKKLGAHVQSNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCE 630
            |.|.|.|    ::.||:.:..|..::    :..|:|:..:..|..:...:|.|:..     ::|.
Worm   646 ENARTAGALQAIMEKKISSKAQQTVF----RHFIDRIVPLSFDVPTAKEIIHLVSD-----TVCA 701

  Fly   631 EIGIS--AQEAGERGLKLLAMLSYVFSAHFFTDTSLRHLI--SLLSYEQDYVAPLVLKTL----- 686
            ::.:.  |:...|:.|.||.:.:..| .:.|.|..:...|  .:|:.|:.......|..|
Worm   702 KVDLKKWAENCFEKDLSLLKIFTDNF-GYLFADEQIIEEIRSKILASEEPIAIEAALHVLSKIFA 765

  Fly   687 ------------THLGRYQPLI----------DDPTPAILDELAPVCK------DFALIGTPK-- 721
                        ||..::..|:          ::|      ||...||      .| ::|..|
Worm   766 NSHFRNKLENEATHKEKWFLLLGKDLKDLVMREEP------ELRRSCKLATRLLSF-ILGKEKVI 823

  Fly   722 -----QAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFNEIIETLRLKLTPNCEHQRT 781
                 |.:..:..:::.||.:|:             ..|.:..||             .|:
Worm   824 EFFDDQIEQLISRLYIESQGAAN-------------AFQVLGEIF-------------RCD---- 858

  Fly   782 KIVTLGHIAYNMPQAFLTPIKNMI-ARRIVKELLIQEVPAQRD----YELP--EDSDWCAQEKLP 839
                   |:|.:||     :.::: :.:|...:|...:....|    .||.  |...|      |
Worm   859 -------ISYYLPQ-----VMDVVESEKIGPMILTSSMHGNDDPVEFNELMHIEKQPW------P 905

  Fly   840 PDTLCKLDALKAMARWLL---------GLRTDEHAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKS 895
            ...:.|:.|.|...:.|.         ..|..|.|||....:|:..:.::|||.|:.  |..|::
Worm   906 KYAMAKVYAAKFATKVLTVYPLIPSTEDKRRMEKAAQNFIDLLSEIIEKKGDLGGKQ--CDLEQA 968

  Fly   896 WLRLGAACAMLKVCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPL 960
            .||..|:..:||:........:.:...:..:|.::.|....||..:|..:.||||    :|.||:
Worm   969 RLRATASGCLLKLASVITYRTKLNTHIFKNMSYIITDEAYCVRLYYALHVKKGLS----KNRLPI 1029

  Fly   961 DFMGLYVLAGLETERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSS----TESQSLHI------ 1015
            :|...|.|..|           ..:|.|...:.:..||:.|.....:    .::|:..:
Worm  1030 EFAACYGLVNL-----------GLSEEDGENKMDGFKTICMNQAQQAFGERNDNQATLLKLEGPQ 1083

  Fly  1016 ----LPDYMLAFAIPVLVHDPRF------TNHEDYVQ-----------LRKMEKCLRFILEPL-M 1058
                ..:.::|:.:.:|.:..:.      .|..|..:           |.::::.|..:::.| :
Worm  1084 RAIFCSESVIAYVVWLLANYDKLEKVEGNANRNDSSEELEIKVANVNLLSELQESLWLVIDSLKI 1148

  Fly  1059 AKRETFVHSFYKQLLQLIKHREFSLGSD--------KRDNYKMWALCDLAMYIIDSKFSPFDGNT 1115
            ||..  :...:|.|.:|....:.|:.||        :..|.|:|.||||.:
Worm  1149 AKCN--MQKVWKVLEKLKTCGDKSMRSDSSLSTTRLREHNEKLWVLCDLGI-------------- 1197

  Fly  1116 STFSMPLALPEMYYKEPAVANFQNNDVYI--------PLDVY----------------------- 1149
             |..:..|..:|..:|...|.|.....|:        |.:||
Worm  1198 -TMMLYRAKLQMEDQEAKEAGFNLQFFYVCSPKDKADPSNVYAPDVLINDEKNRNGRIPKPGRVF 1261

  Fly  1150 -----------------TLGAKSTSKAAATAMTT----SRAAVAPKRPAEQS----IMDDENPQE 1189
                             :.|:.|:..|:..|..|    .|.....|....:|    |.|||..
Worm  1262 HVSDLTSEFTPPPQGNESTGSNSSKNASRRANVTGTGRKRGGAGTKTTKRKSGGSKISDDEGD-- 1324

  Fly  1190 NNLFDNIRAADTTEPMAKRTRA 1211
                    :.|...|..|:||:
Worm  1325 --------SMDVKSPAVKKTRS 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pds5	NP_001246271.1	None
evl-14	NP_497865.2	PTZ00449	<1333..>1524	CDD:185628	3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167195
Domainoid	1	1.000	183	1.000	Domainoid score	I2039
eggNOG	1	0.900	-	-		E1_KOG1525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41001
Inparanoid	1	1.050	184	1.000	Inparanoid score	I2622
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55449
OrthoDB	1	1.010	-	-		D56082at33208
OrthoFinder	1	1.000	-	-		FOG0001888
OrthoInspector	1	1.000	-	-		oto17380
orthoMCL	1	0.900	-	-		OOG6_101478
Panther	1	1.100	-	-	LDO	PTHR12663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3128
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800