Protein Alignment pds5 and Pds5b

DIOPT Version :9

• Sequence 1: NP_001246271.1
• Gene: pds5 / 36286
• FlyBaseID: FBgn0260012
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_006504964.1
• Gene: Pds5b / 100710
• MGIID: 2140945
• Length: 1449
• Species: Mus musculus
• Alignment Length: 1190
• Identity: 443/1190 - (37%)
• Similarity: 693/1190 - (58%)
• Gaps: 79/1190 - (6%)

  Fly     4 IVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQDDNLYQQ-YIPLALHLLDDFFMQHPSRDVQ 67
            |.||.|.:.:.:.:..:|::||||.:......||||....:: |:.|||||..|||::||.:||:
Mouse    13 ITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVR 77

  Fly    68 LLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFN 132
            ||:|||:||:.|:|||||||...|::|.||.|..:||.||:|.:.|.|.||||||||:|:|||:|
Mouse    78 LLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYN 142

  Fly   133 MCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPY 197
            :||||||..|||..|:.|:|.::|:.|:.||....:|::|.:|.|.|.:|.||||.:|:|:|..:
Mouse   143 ICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAH 207

  Fly   198 KSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLS-ITNKIYDIIYELNRINAGLL 261
            |:.||.|..|.:.||.:|..|:|..|..|||:.|::.|  |.:| ::..::|:|.||..|::.||
Mouse   208 KNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGK--TSISDLSEHVFDLILELYNIDSHLL 270

  Fly   262 CSVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQ 326
            .|||||||.||.|.|:.|||:...||::||..|||:||.:...|.:.:.|||.||..|:|::||:
Mouse   271 LSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVK 335

  Fly   327 SSMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTL 391
            .:.|.|:|||.|..|:||.|::|:||.:|.:||:|:::||..||:|..||.:  .||..||||||
Mouse   336 FASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVND--HLLNFVRERTL 398

  Fly   392 DKKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITC 456
            ||::::|::||.|||.|||:...:........| ::.|:|:|:||.||:..::|||||||:....
Mouse   399 DKRWRVRKEAMMGLAQIYKKYSLQSAAGKDAAK-QISWVKDKLLHIYYQNSIDDRLLVERIFAQY 462

  Fly   457 LVPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRVLSQLS 521
            :||:.|...||||.||:|...||.||.||..|:.|.|...|:.|.|.:.|....: |...:..:.
Mouse   463 MVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPK-TDASVKAIF 526

  Fly   522 AKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHV 586
            :|...|.:.||||.||.:::.:|:..|..|.::.:.:..::....||::....:..:.||||...
Mouse   527 SKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEALVSPTCSCKQAEGCVREITKKLGNPK 591

  Fly   587 Q-SNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAML 650
            | :|.:...:|.|:||:|.|.:|.|||..||..:.:.|:..:..|:.|:...:|...||:||.:|
Mouse   592 QPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVL 656

  Fly   651 SYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFA 715
            |:.....|.:..:...|::.|..:.:.||...|:...:.|   ..|::..|.|...|.||....:
Mouse   657 SFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTG---SKIEEDFPHIRSALLPVLHHKS 718

  Fly   716 LIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFNEIIETLRLKLTP-NCEHQ 779
            ..|.|:|||:|:.||.               |..:|..||     |.:|.|.|...|.| |.||.
Mouse   719 KKGPPRQAKYAIHCIH---------------AIFSSKETQ-----FAQIFEPLHKSLDPSNLEHL 763

  Fly   780 RTKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQE-VPAQRDYELPEDSDWCAQEKLPPDTL 843
            .|.:||:||||...|..|..|:|:::|..|||:||:.: :|.::..:|     |...|::.|:|:
Mouse   764 ITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKL-----WVPDEEVSPETM 823

  Fly   844 CKLDALKAMARWLLGLRTD-EHAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLGAACAMLK 907
            .|:.|:|.|.|||||::.: ..:...|.|:|...::..|||..|.::...:.|.|||.|..|::|
Mouse   824 VKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVK 888

  Fly   908 VCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGLYVLAGLE 972
            :.::....:..:.|||...:..:.|...:||::||:||||||||..    |||::|.:..|...:
Mouse   889 LAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLR----LPLEYMAICALCAKD 949

  Fly   973 TERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVHDPRFTNH 1037
            ..::.:...|.....::..||||||..|..|      .:.|.:||:|::.:.|.:|.|||.:...
Mouse   950 PVKERRAHARQCLVKNITVRREYLKQHAAVS------EKLLSLLPEYVVPYTIHLLAHDPDYVKV 1008

  Fly  1038 EDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIKHREFSLG-SDKRDNYKMWALCDLAM 1101
            :|..||:.:::||.|:||.||||.|...|:|.:::::.||..:.:.| .|.:.|.|::.:||:||
Mouse  1009 QDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDTKMNEKLYTVCDVAM 1073

  Fly  1102 YIIDSKFSPFDGNTSTFSM-----PLALPEMYYKEPAVANFQNNDVYIPLDVYT----------- 1150
            .||.||       ::|:|:     |: ||..::.:|. .||.|...|:|.::.:
Mouse  1074 NIIMSK-------STTYSLESPKDPV-LPARFFTQPD-KNFSNTKNYLPPEMKSFFTPGKPKTAN 1129

  Fly  1151 -LGA--KSTSKAAATAMTTS 1167
             |||  |..|.|...:.|.|
Mouse  1130 VLGAVNKPLSSAGKQSQTKS 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pds5	NP_001246271.1	None
Pds5b	XP_006504964.1	HEAT repeat	240..261	CDD:293787	6/22 (27%)
		HEAT repeat	273..303	CDD:293787	17/29 (59%)
		HEAT repeat	313..339	CDD:293787	10/25 (40%)
		HEAT repeat	350..376	CDD:293787	12/25 (48%)
		DMP1	<1175..1433	CDD:369294

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841004
Domainoid	1	1.000	743	1.000	Domainoid score	I93
eggNOG	1	0.900	-	-		E1_KOG1525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41001
Inparanoid	1	1.050	747	1.000	Inparanoid score	I580
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55449
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001888
OrthoInspector	1	1.000	-	-		otm42930
orthoMCL	1	0.900	-	-		OOG6_101478
Panther	1	1.100	-	-	O	PTHR12663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3128
SonicParanoid	1	1.000	-	-		X1823
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790