Protein Alignment pds5 and pds5b

DIOPT Version :10

• Sequence 1: NP_610719.1
• Gene: pds5 / 36286
• FlyBaseID: FBgn0260012
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001107500.1
• Gene: pds5b / 100135353
• XenbaseID: XB-GENE-6041340
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 1182
• Identity: 440/1182 - (37%)
• Similarity: 692/1182 - (58%)
• Gaps: 69/1182 - (5%)

  Fly     4 IVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQD-DNLYQQYIPLALHLLDDFFMQHPSRDVQ 67
            |.||.|.:.:.:.:..:|::||||.:......|||| :...:.|:.|||||..|||::||.:||:
 Frog    13 ITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKEHYLNLALHLASDFFLKHPDKDVR 77

  Fly    68 LLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFN 132
            ||:|||:||:.|:|||||||...:::|.||.|..:||.||:|.:.|.|.||||||||:|:|||:|
 Frog    78 LLVACCLADIFRIYAPEAPYTSPEKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYN 142

  Fly   133 MCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPY 197
            :||||||..|||..|:.|:|.::|:.|:.||....:|::|.::.|.|.:|.||||.:|:|:|..:
 Frog   143 ICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIVCEGDTVSQELLDSVLVNLVPAH 207

  Fly   198 KSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLS-ITNKIYDIIYELNRINAGLL 261
            |:.||.|..|.:.||.:|..|:|..|..|||:.|::.|  |.:| ::..::|:|.||..|::.||
 Frog   208 KNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGK--TSISDLSEHVFDLILELYNIDSHLL 270

  Fly   262 CSVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQ 326
            .|||||||.||.|.|:.|||:...||::||..|||:||.:...|.:.:.|||.||..|:|::||:
 Frog   271 LSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVK 335

  Fly   327 SSMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTL 391
            .:.|.|:|||.|..|:||.|::|:||.:|.:||:|:::||..||:|..||.:  .||..||||||
 Frog   336 FASHSLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDLLLVND--QLLNFVRERTL 398

  Fly   392 DKKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITC 456
            ||::::|::||.|||.|||:...:........| ::.|||:|:||.||:..::|||||||:....
 Frog   399 DKRWRVRKEAMMGLAQIYKKYSLQGEAGKESAK-QISWIKDKLLHIYYQNSIDDRLLVERIFAQY 462

  Fly   457 LVPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRVLSQLS 521
            :||:.|...||||.||:|...||.||.||..|:.|.|...|:.|.|.:.| ..|..|......:.
 Frog   463 MVPHNLETTERMKCLYYLYATLDTNAVKALNEMWKCQNMLRHHVKDLLDL-IQKPKTEAGSKAIF 526

  Fly   522 AKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHV 586
            :|...|.:.||||.|..::|.:|:..|..|.::...:..::....||:|....:..:.||||...
 Frog   527 SKVMVITRNLPDPGKGQDFLKKFTQVLEDDEKIRGQLEKLVSPTCSCKEAEVCVRDITKKLGNPK 591

  Fly   587 Q-SNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAML 650
            | :|.:...:|.|:||:|.|.:|.|||..||.|:.:.|:..:..|:.|:...:|...||:||.:|
 Frog   592 QPTNPFLEMIKFLLERIAPVHIDTESISSLIKLVNKSIDGTADDEDEGVPTDQAIRAGLELLKVL 656

  Fly   651 SYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFA 715
            |:.....|.:..:...|::.|..:.:.||...|:...:.|   ..|::..|.|...|.||.:..|
 Frog   657 SFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTG---GKIEEDFPHIRSALLPVLQQKA 718

  Fly   716 LIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFNEIIETLRLKLTP-NCEHQ 779
            ..|..:|||:::.||.               |..:|..||     |.:|.|.|...|.| |.|..
 Frog   719 KKGPSRQAKYSIHCIH---------------AIFSSKETQ-----FAQIFEPLHKSLDPGNPEQL 763

  Fly   780 RTKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQE-VPAQRDYELPEDSDWCAQEKLPPDTL 843
            .|.:|::||||...|..|..|:|:|:|..:||:||:.: :|.::..:|     |.:.:::..:|:
 Frog   764 ITSLVSIGHIAQLAPDQFTAPLKSMVATFVVKDLLMTDRLPGKKTTKL-----WVSDDEVSAETM 823

  Fly   844 CKLDALKAMARWLLGLRTD-EHAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLGAACAMLK 907
            .|:.|:|.|.|||||::.: ..:...|.|:|.|.::..|||....:|...:.|.|||.|:||::|
 Frog   824 VKIQAIKMMVRWLLGMKNNLSKSGNSTLRLLTAILHTDGDLTEHGKLSKPDMSRLRLAASCAIVK 888

  Fly   908 VCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGLYVLAGLE 972
            :.::....:..:.:||...:..:.|...:||:|||:||||||||..    |||::|.:..|...:
 Frog   889 LAQEPCYHEIITLDQYQLCALAINDECYQVRQIFAQKLHKGLSRLR----LPLEYMAICALCAKD 949

  Fly   973 TERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVHDPRFTNH 1037
            ..::.:...|.....::|.||||||..|..|      .:...:||:|::.:.:.:|.|||.:...
 Frog   950 PVKERRAHARQCLVKNINVRREYLKQHAAVS------EKLFSLLPEYVVPYTVHLLAHDPDYVKV 1008

  Fly  1038 EDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIKH-REFSLGSDKRDNYKMWALCDLAM 1101
            :|..||:.:::||.|:||.||:|.|...|:|.:::::.||. ::.....|::.|.||:.:||:||
 Frog  1009 QDIEQLKDIKECLWFVLEILMSKNENNSHAFIRKMVEYIKQTKDAQNPEDQKMNEKMYTVCDVAM 1073

  Fly  1102 YIIDSKFSPFDGNTSTFSM-----PLALPEMYYKEPAVANFQNNDVYIPLDV---YTLG-AKSTS 1157
            .||.||       ::|:|:     |: ||..::.:|. .||.|...|:|.::   :|.| .|||:
 Frog  1074 NIIISK-------STTYSLESPKDPV-LPARFFTQPD-KNFSNTKNYLPAELKSFFTPGKPKSTN 1129

  Fly  1158 KAAATAMTTSRA 1169
            ...|.....|.|
 Frog  1130 VLGAVNKPLSSA 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pds5	NP_610719.1	PDS5	20..1130	CDD:466319	422/1121 (38%)
pds5b	NP_001107500.1	PDS5	29..1099	CDD:466319	422/1121 (38%)
		HEAT repeat	240..261	CDD:293787	6/22 (27%)
		HEAT repeat	273..303	CDD:293787	17/29 (59%)
		HEAT repeat	313..341	CDD:293787	11/27 (41%)
		HEAT repeat	350..376	CDD:293787	12/25 (48%)
		Treacle	1176..>1440	CDD:460967