DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk2 and PTK7

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens

Alignment Length:	412	Identity:	131/412 - (31%)
Similarity:	187/412 - (45%)	Gaps:	64/412 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SITIKEQSS-LQLPCDYQLPD---GYLQ-------KSSVILRWRKDSKTLRQVELGRMDSTTSEP 95
            :||:....| |:.|.|.||.:   |||.       |.:|:  |.::
Human   413 NITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVV--WYRN------------------- 456

  Fly    96 QLETMLREDSRVALSKDSGALQFTSVLASDAGQYQCQLVIDDSVAASS--SSGVLLVIEQLKFVP 158
              :.::.||||..:.| :|.|:..||...|...|:|.    .|..|.|  :...:.|:|:|||.|
Human   457 --QMLISEDSRFEVFK-NGTLRINSVEVYDGTWYRCM----SSTPAGSIEAQARVQVLEKLKFTP 514

  Fly   159 QPTSKN-LELGTLSKVHCKAQGTPAPQVKWMRETQLPLPVNVTDQNGTLIFNQVSNEQRGQYTCI 222
            .|..:. :|....:.|.|.|.|...|.:||.|.....||..|||..|||.|.:|:.:..|.||||
Human   515 PPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCI 579

  Fly   223 ASNS-QGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQWDKDLTYLNEN 286
            |||. ||||.|.|.:.|.|...|.|.|| ...|.:..||::.|:|.|:|||.|||......|:..
Human   580 ASNGPQGQIRAHVQLTVAVFITFKVEPE-RTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT 643

  Fly   287 NTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDVLL------VLKSSKSASNSIVT 345
            ...| |..:.:||:|.|.:|.|||.|||.|..|:|..:|..:..|      |.:.|:...:....
Human   644 KLGP-RMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPY 707

  Fly   346 RIIIVI---ICLAFLYFVLVLGLKVWYRYRRHLGKVQLE-DGHV-------NGP-TDGQEHDHHE 398
            ::|..|   :..|..|.:.||||..:.:.|....::|.: :|..       .|| .:||.....:
Human   708 KMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQ 772

  Fly   399 NEPCLTEANSSKNLKSKLREST 420
            .|..||...|.....:| |.||
Human   773 EEVALTSLGSGPAATNK-RHST 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	25/100 (25%)
		I-set	155..238	CDD:254352	37/84 (44%)
		IGc2	175..228	CDD:197706	25/53 (47%)
		IG_like	250..331	CDD:214653	30/80 (38%)
		IGc2	258..323	CDD:197706	28/64 (44%)
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237
		IG_like	239..>309	CDD:214653
		Ig	250..310	CDD:143165
		IG	348..416	CDD:214652	1/2 (50%)
		IGc2	348..406	CDD:197706
		I-set	420..506	CDD:254352	27/113 (24%)
		Ig	422..506	CDD:299845	26/111 (23%)
		I-set	511..596	CDD:254352	37/84 (44%)
		IGc2	528..582	CDD:197706	24/53 (45%)
		IG_like	606..689	CDD:214653	33/84 (39%)
		IGc2	613..677	CDD:197706	27/64 (42%)
		PTK_CCK4	798..1071	CDD:133178
		STYKc	809..1069	CDD:214568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147251
Domainoid	1	1.000	55	1.000	Domainoid score	I11116
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245153at33208
OrthoFinder	1	1.000	-	-		FOG0007317
OrthoInspector	1	1.000	-	-		otm41120
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750