DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk2 and hmcn2

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	XP_001920501.5	Gene:	hmcn2 / 565032	ZFINID:	ZDB-GENE-030131-9765	Length:	4212	Species:	Danio rerio

Alignment Length:	338	Identity:	93/338 - (27%)
Similarity:	145/338 - (42%)	Gaps:	60/338 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 STTSEP--------QLETMLRED-----SRVALSKDSG--------ALQFTSVLASDAGQYQCQL 133
            :.||.|        |::..:|.:     :..||...||        :|:.:.|.:.|||.|||:.
Zfish   524 NVTSSPGTVAVLSCQIQGSVRHNLTWYRTGSALPSRSGRVRVLANSSLEISWVRSQDAGPYQCRA 588

  Fly   134 VIDDSVAASSSSGV--LLVIEQLKFVPQPTSKNLELGTLSKVHCKAQGTPAPQVKWMRETQLPLP 196
                |.|...|..|  |:|:|....|..|.:::..||....:.|.|.|:|.|:|.|...
Zfish   589 ----SNAHGESQAVVWLVVLEAPSVVVSPQTQSFSLGAEVHISCSASGSPPPKVFWSHG------ 643

  Fly   197 VNV---------TDQNGTLIFNQVSNEQRGQYTCIASNSQGQITATVSINVVVAPKFSVPPEGPI 252
             |:         ..::|.|.....:.|..|.|||:|:|..|..:.:|::|....|..||..: .:
Zfish   644 -NIFLSNHHRMSISESGMLTIRGAAPEDSGNYTCLATNEVGTASQSVNVNYAEPPSISVVQQ-MV 706

  Fly   253 EVAEAGTAVIHCQAIGEPKPTIQWDK-DLTYLNENNTDPERFSLMENGTLEIRNVRPEDEGRYGC 316
            .|.....|.:.|||.|.|.|.::|.| ||    :..|.|.....:..|||:||.|:..|.|.|.|
Zfish   707 MVVAGEDASLECQASGTPSPIVKWQKGDL----DLGTAPFAEQDVHRGTLQIRGVQELDSGDYTC 767

  Fly   317 TIGSSAGLKREDVLLVLKSSKSASNSIV--TRII---IVIICLA------FLYFVLVLGLKVWYR 370
            ...:.||.....|:|.:.::.:.|.|.|  |..:   |.:.|:|      .|.:....|..::.:
Zfish   768 VASNIAGSSSAVVVLQVGAAPTFSESPVDITASVGDNITLPCIARGFPTPSLIWRRQDGRPIFGK 832

  Fly   371 YRRHLGKVQLEDG 383
            ...|:|..||..|
Zfish   833 SSGHVGTSQLPSG 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	16/62 (26%)
		I-set	155..238	CDD:254352	23/91 (25%)
		IGc2	175..228	CDD:197706	17/61 (28%)
		IG_like	250..331	CDD:214653	27/81 (33%)
		IGc2	258..323	CDD:197706	23/65 (35%)
hmcn2	XP_001920501.5	VWA_2	38..208	CDD:290253
		IG	441..512	CDD:214652
		Ig	441..502	CDD:299845
		I-set	516..603	CDD:254352	22/82 (27%)
		Ig	533..600	CDD:143165	18/70 (26%)
		IG	613..691	CDD:214652	22/84 (26%)
		Ig	624..690	CDD:143165	18/72 (25%)
		IG	710..784	CDD:214652	27/77 (35%)
		Ig	714..781	CDD:143165	25/70 (36%)
		IG	794..879	CDD:214652	12/52 (23%)
		Ig	794..879	CDD:299845	12/52 (23%)
		I-set	885..972	CDD:254352
		Ig	904..972	CDD:299845
		IG_like	982..1063	CDD:214653
		IGc2	989..1053	CDD:197706
		IG_like	1083..1159	CDD:214653
		Ig	1089..1156	CDD:143165
		I-set	1163..1241	CDD:254352
		IGc2	1176..1231	CDD:197706
		Ig	1244..1327	CDD:299845
		IG_like	1258..1335	CDD:214653
		Ig	1338..1430	CDD:299845
		I-set	1344..1428	CDD:254352
		IG_like	1441..1523	CDD:214653
		IGc2	1448..1513	CDD:197706
		IG_like	1536..1616	CDD:214653
		IGc2	1545..1606	CDD:197706
		IG_like	1638..1714	CDD:214653
		Ig	1644..1711	CDD:143165
		IG_like	1753..1830	CDD:214653
		Ig	1760..1822	CDD:143165
		I-set	1834..1918	CDD:254352
		Ig	1851..1925	CDD:299845
		IG_like	1937..2017	CDD:214653
		IGc2	1943..2007	CDD:197706
		IG_like	2031..2110	CDD:214653
		IGc2	2039..2100	CDD:197706
		I-set	2114..2202	CDD:254352
		IGc2	2129..2192	CDD:197706
		IG	2214..2295	CDD:214652
		IGc2	2222..2287	CDD:197706
		I-set	2307..2391	CDD:254352
		IGc2	2321..2381	CDD:197706
		I-set	2400..2484	CDD:254352
		IGc2	2410..2474	CDD:197706
		IG_like	2496..2576	CDD:214653
		IGc2	2507..2566	CDD:197706
		IG	2589..2669	CDD:214652
		IGc2	2597..2659	CDD:197706
		IG	2679..2760	CDD:214652
		IGc2	2687..2750	CDD:197706
		I-set	2764..2851	CDD:254352
		Ig	2770..2845	CDD:299845
		IG	2863..2943	CDD:214652
		Ig	2873..2942	CDD:299845
		IG_like	2954..3032	CDD:214653
		IGc2	2963..3023	CDD:197706
		IG_like	3046..3122	CDD:214653
		IGc2	3051..3113	CDD:197706
		IG_like	3133..3214	CDD:214653
		Ig	3144..3213	CDD:299845
		IG	3224..3303	CDD:214652
		IGc2	3232..3293	CDD:197706
		IG_like	3316..3394	CDD:214653
IGc2	3321..3384	CDD:197706
TSP1	3401..3452	CDD:214559
G2F	3455..3636	CDD:284812
EGF_CA	3691..3721	CDD:214542
Furin-like	3728..3857	CDD:279142
EGF_CA	3731..3774	CDD:284955
EGF_CA	3776..3814	CDD:214542
EGF_CA	3816..3849	CDD:238011
EGF_CA	3858..3899	CDD:284955
EGF_CA	3901..3940	CDD:214542
EGF_CA	4005..4044	CDD:214542
EGF_CA	4045..4085	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900