DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment otk2 and hmcn1

DIOPT Version :9

Sequence 1:NP_612571.1 Gene:otk2 / 36284 FlyBaseID:FBgn0267728 Length:433 Species:Drosophila melanogaster
Sequence 2:XP_005160777.1 Gene:hmcn1 / 559150 ZFINID:ZDB-GENE-041014-322 Length:5623 Species:Danio rerio


Alignment Length:484 Identity:106/484 - (21%)
Similarity:166/484 - (34%) Gaps:175/484 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 TIKEQSSLQLPCDYQLPDGYLQKSSVILRWRKDSKTLRQVELGRMDSTTSEPQLETMLREDSRVA 108
            |:....|:.|.|:   .:|:...|   :.|.||.:.|.:....|:.||                 
Zfish  4074 TVALDVSVTLQCN---SEGFPTPS---VSWHKDGQLLSESVRQRVLST----------------- 4115

  Fly   109 LSKDSGALQFTSVLASDAGQYQCQLVIDDSVAASSSSGVLLVIEQLKFVPQPTSKNLELG----- 168
                 ||||.......|.|:|.|.:.   :||.|||..:.|.::    :|    .::.:|     
Zfish  4116 -----GALQIAFAQPGDTGRYTCTVA---NVAGSSSLDISLTV
Q----IP----PSIRVGESEVS 4164

  Fly   169 ----TLSKVHCKAQGTPAPQVKWMRETQLPLPVNVTD----QNGTLIFNQVSNEQRGQYTCIASN 225
                |.:.:.|.|.|.|.|.:.|.:: .:||.....:    ..|.|:.:....|..|.|||:.:|
Zfish  4165 VVENTQALLTCVADGVPQPTITWEKD-DIPLTDTTAEYTILPTGDLLIDTAQPEDSGSYTCVGTN 4228

  Fly   226 SQGQITATVSINVVVAPKFS----------------------VPP-------------------- 248
            |.||.:.|:|:::...|.|:                      :||                    
Zfish  4229 SMGQDSRTISLSIHTHPAFTELLGDVALNKRERLLMVCGVTGIPPPKITWTFNNNIVPAQYDHYN 4293

  Fly   249 --------------------------------------EGPIEVAE---------AGTAVIHCQA 266
                                                  |.||...:         .|.|:::|:.
Zfish  4294 GHSELVIERVSKDDSGTYTCMAENSVGSIKSLGFVYVKEPPIIDGDVHSNRIEPLGGNAILNCEV 4358

  Fly   267 IGEPKPTIQWDKDLTYLNENNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDVLL 331
            .|:|.|||||.|....:..:|    |...::||:|.|.....||.|.|.|...:.||:....|.|
Zfish  4359 RGDPLPTIQWSKKGINVQISN----RIRQLDNGSLAIYGTVSEDAGNYMCVATNDAGVVERTVTL 4419

  Fly   332 VLKSSKSASNSIVTRII-----IVIICLAFLYFVLVLGLKVWYRYRRHLGKVQLEDGHVNGPTDG 391
            .|:.|.:.:...|..::     :|:.|.|....|.|:   .|.|..|              |..|
Zfish  4420 TLQRSPTITVEPVETVVDAGSTVVLNCQAEGEPVPVI---EWSRQGR--------------PLLG 4467

  Fly   392 QEHDHHENEPCLTEANSSKNLKSKLREST 420
            .||....|       |.|..|:|..:|.|
Zfish  4468 NEHITALN-------NGSLRLRSAQKEDT 4489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otk2NP_612571.1 IG_like 41..132 CDD:214653 20/87 (23%)
I-set 155..238 CDD:254352 24/95 (25%)
IGc2 175..228 CDD:197706 17/56 (30%)
IG_like 250..331 CDD:214653 27/89 (30%)
IGc2 258..323 CDD:197706 22/64 (34%)
hmcn1XP_005160777.1 VWA_2 36..206 CDD:290253
IG_like 443..510 CDD:214653
I-set 514..600 CDD:254352
ig 522..596 CDD:278476
I-set 604..688 CDD:254352
Ig 618..689 CDD:299845
I-set 694..781 CDD:254352
IGc2 708..771 CDD:197706
I-set 785..876 CDD:254352
Ig 789..876 CDD:299845
IG 888..969 CDD:214652
IGc2 895..959 CDD:197706
I-set 973..1060 CDD:254352
Ig 990..1059 CDD:299845
IG 1084..1162 CDD:214652
Ig 1092..1159 CDD:143165
I-set 1166..1251 CDD:254352
IGc2 1179..1241 CDD:197706
I-set 1251..1348 CDD:254352
Ig 1254..1348 CDD:299845
I-set 1360..1441 CDD:254352
IGc2 1367..1431 CDD:197706
I-set 1450..1535 CDD:254352
IGc2 1461..1525 CDD:197706
IG_like 1547..1628 CDD:214653
Ig 1558..1625 CDD:143165
I-set 1641..1722 CDD:254352
Ig 1641..1718 CDD:299845
Ig 1725..1817 CDD:299845
IG 1738..1815 CDD:214652
Ig 1818..1908 CDD:299845
IG 1826..1908 CDD:214652
IG 1922..2001 CDD:214652
Ig 1927..2001 CDD:299845
IG 2014..2093 CDD:214652
IGc2 2019..2083 CDD:197706
Ig 2096..2186 CDD:299845
IG_like 2107..2184 CDD:214653
Ig 2187..2280 CDD:299845
I-set 2197..2277 CDD:254352
Ig 2292..2371 CDD:299845
IG 2292..2369 CDD:214652
I-set 2373..2463 CDD:254352
IGc2 2391..2453 CDD:197706
IG 2476..2556 CDD:214652
IGc2 2484..2546 CDD:197706
IG 2572..2652 CDD:214652
IGc2 2583..2642 CDD:197706
I-set 2670..2751 CDD:254352
IGc2 2678..2741 CDD:197706
IG 2774..2850 CDD:214652
IGc2 2777..2840 CDD:197706
I-set 2864..2945 CDD:254352
Ig 2864..2938 CDD:299845
Ig 2949..3039 CDD:299845
IG_like 2957..3037 CDD:214653
I-set 3051..3132 CDD:254352
IGc2 3059..3122 CDD:197706
I-set 3154..3226 CDD:254352
Ig 3154..3223 CDD:143165
Ig 3229..3323 CDD:299845
I-set 3238..3321 CDD:254352
IG 3335..3415 CDD:214652
Ig 3343..3415 CDD:299845
Ig 3418..3508 CDD:299845
IG 3428..3508 CDD:214652
IG 3520..3601 CDD:214652
Ig <3533..3603 CDD:299845
I-set 3614..3694 CDD:254352
IGc2 3620..3684 CDD:197706
Ig 3697..3787 CDD:299845
IG_like 3704..3785 CDD:214653
Ig 3788..3878 CDD:299845
I-set 3789..3878 CDD:254352
IG_like 3891..3969 CDD:214653
Ig 3899..3968 CDD:299845
IG_like 3979..4060 CDD:214653
Ig 3990..4052 CDD:299845
I-set 4064..4150 CDD:254352 27/106 (25%)
IGc2 4080..4140 CDD:197706 21/90 (23%)
Ig 4161..4241 CDD:299845 22/80 (28%)
IG_like 4161..4241 CDD:214653 22/80 (28%)
I-set 4245..4324 CDD:254352 4/78 (5%)
IGc2 4260..4320 CDD:197706 2/59 (3%)
Ig 4352..4420 CDD:299845 24/71 (34%)
I-set 4425..4511 CDD:254352 20/89 (22%)
Ig 4439..4512 CDD:299845 19/75 (25%)
TSP1 4518..4569 CDD:214559
TSP1 4583..4626 CDD:214559
TSP1 4631..4683 CDD:214559
TSP1 4688..4740 CDD:214559
TSP1 4745..4797 CDD:214559
TSP1 4802..4854 CDD:214559
nidG2 4855..5070 CDD:238158
EGF_CA 5091..5130 CDD:214542
EGF_CA 5131..5174 CDD:284955
EGF_CA 5176..5213 CDD:214542
EGF_CA 5214..5251 CDD:214542
EGF_CA 5256..5297 CDD:284955
EGF_CA 5299..5338 CDD:214542
EGF_CA 5420..5459 CDD:214542
EGF_CA 5460..5496 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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