Protein Alignment otk2 and LRRN3

DIOPT Version :10

• Sequence 1: NP_612571.1
• Gene: otk2 / 36284
• FlyBaseID: FBgn0267728
• Length: 433
• Species: Drosophila melanogaster
• Sequence 2: NP_060804.3
• Gene: LRRN3 / 54674
• HGNCID: 17200
• Length: 708
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 80/400 - (20%)
• Similarity: 142/400 - (35%)
• Gaps: 145/400 - (36%)

  Fly    23 SYAAPASF------EDVSISRGPKSSI---------TIKEQS--SLQLPCDYQLPDGYLQKSSVI 70
            ||..|.:|      |.:.::....|::         .:||.|  |..:.||            .:
Human   323 SYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCD------------CV 375

  Fly    71 LRWRKDSKTLRQVELGRMDSTTSEPQLETMLREDSRVALSKDSGALQFTSVLASDAGQYQCQLVI 135
            :||...:||         :....||.                       |:...|..::|.|.|
Human   376 IRWMNMNKT---------NIRFMEPD-----------------------SLFCVDPPEFQGQNV- 407

  Fly   136 DDSVAASSSSGVLLVIEQLKF-----------VPQ--PTSKNLELGTLSKVHCKAQGTPAPQVKW 187
                            .|:.|           .|:  |::.|:|.|:....||:|...|.|::.|
Human   408 ----------------RQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYW 456

  Fly   188 MRET-QLPLPVNVTDQ-----NGTLIFNQVSNEQRGQYTCIASNSQGQITATVSINVVVAPKFSV 246
            :..: |..||..:||:     .|||..|.|:.::.|.|||||:|..|....:|.|.  |...|..
Human   457 ITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIK--VDGSFPQ 519

  Fly   247 PPEGPIEV----AEAGTAVIHCQAIGE-PKPTIQWDK----------------------DLTYLN 284
            ...|.:.:    .:|.:.::..:|..: .|.:::|..                      :||:||
Human   520 DNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLN 584

  Fly   285 ENNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDVLLVLKSSKSASNSIVTRI-- 347
            .:.   |....::..|:..:|       |..|...::.||..:.    .:..|:.:.:::..:
Human   585 PST---EYKICIDIPTIYQKN-------RKKCVNVTTKGLHPDQ----KEYEKNNTTTLMACLGG 635

  Fly   348 ---IIVIICL 354
               ||.:|||
Human   636 LLGIIGVICL 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	Ig	<98..>131	CDD:472250	2/32 (6%)
		Ig strand E	114..118	CDD:409560	0/3 (0%)
		Ig_3	155..225	CDD:464046	28/88 (32%)
		Ig	249..323	CDD:472250	14/100 (14%)
		Ig strand B	260..264	CDD:409544	0/3 (0%)
		Ig strand C	273..277	CDD:409544	0/3 (0%)
		Ig strand E	299..303	CDD:409544	1/3 (33%)
		Ig strand F	313..318	CDD:409544	2/4 (50%)
LRRN3	NP_060804.3	LRRNT	28..72	CDD:214470
		LRR	<69..354	CDD:443914	6/30 (20%)
		LRR 1	70..91
		leucine-rich repeat	72..93	CDD:275380
		LRR 2	93..114
		leucine-rich repeat	94..117	CDD:275380
		LRR 3	117..138
		leucine-rich repeat	118..141	CDD:275380
		LRR 4	141..162
		leucine-rich repeat	142..165	CDD:275380
		LRR 5	165..186
		leucine-rich repeat	166..189	CDD:275380
		LRR 6	189..210
		leucine-rich repeat	190..213	CDD:275380
		LRR 7	213..234
		leucine-rich repeat	214..237	CDD:275380
		LRR 8	237..258
		leucine-rich repeat	238..261	CDD:275380
		LRR 9	261..282
		leucine-rich repeat	262..285	CDD:275380
		LRR 10	285..304
		leucine-rich repeat	286..310	CDD:275380
		LRR 11	310..332		4/8 (50%)
		leucine-rich repeat	311..333	CDD:275380	4/9 (44%)
		LRR 12	335..358		2/22 (9%)
		leucine-rich repeat	336..359	CDD:275380	2/22 (9%)
		PCC	341..>442	CDD:188093	25/161 (16%)
		Ig	421..513	CDD:472250	31/93 (33%)
		Ig strand B	440..444	CDD:409353	0/3 (0%)
		Ig strand C	453..457	CDD:409353	0/3 (0%)
		Ig strand E	479..483	CDD:409353	3/3 (100%)
		Ig strand F	493..498	CDD:409353	3/4 (75%)
		Ig strand G	506..509	CDD:409353	0/2 (0%)
		fn3	526..593	CDD:394996	9/69 (13%)