DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk2 and Obscn

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001164983.2	Gene:	Obscn / 380698	MGIID:	2681862	Length:	8032	Species:	Mus musculus

Alignment Length:	478	Identity:	99/478 - (20%)
Similarity:	168/478 - (35%)	Gaps:	180/478 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GRRRLLGCGLGFFCLIFCSYAAPASFEDVSISRGPKS---------------------SITIKEQ 48
            |....|.|.|        |.|||.:::     :|||:                     .:|:.:.
Mouse  3620 GTTATLSCEL--------SKAAPVTWK-----KGPKTLQSGDKYVLRQDGAVCGLQIHGLTMADA 3671

  Fly    49 SSLQLPCDYQ----------LPDGYLQK---------SSVILR----------WRKDSKTLRQ-- 82
            ......|..:          ||..:::.         ::.|||          |||.|:||:.
Mouse  3672 GEYSCVCGQEKTSATLTVRGLPAKFIEDLRSQEATEGATAILRCELSKAAPVEWRKGSETLKDGD 3736

  Fly    83 --------------------VELGRMDS------------TTSEPQLETM--------------- 100
                                |:.|...|            ..:|..:.|:
Mouse  3737 RYTLRQDGAVCELQIRGLAVVDTGTYSSLPTKFTEGLRNEEATEGTMATLRCQMSKAAPVEWRKG 3801

  Fly   101 ---LREDSRVALSKDSGA---LQFTSVLASDAGQYQCQLVIDDSVAASSSSGVLLVIEQL--KFV 157
               ||:..|.:|.:| ||   ||...:...|:|:|.|       |.....:...|.::.|  :|:
Mouse  3802 SETLRDGDRYSLRQD-GAMCELQIRGLTIEDSGEYTC-------VCGQEKTSATLSVKALPPRFI 3858

  Fly   158 PQPTSKNLELGTLSKVHCKAQGTPAPQVKWMRETQLPLPVNVTD-------QNGTLIFNQVSN-- 213
            ....|:....||::.:.|  |.:.|..|:|.:.::     .:.|       |||.:...|:.:
Mouse  3859 EDLRSQEATEGTMATLRC--QMSKAAPVEWRKGSE-----TLGDGGRYSLRQNGAVCELQIHDLA 3916

  Fly   214 -EQRGQYTCIASNSQGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQWD 277
             |..|:|:|:.    ||...:.::||...|...:......|..|...|.:.|| :.:..| ::|.
Mouse  3917 VEDTGEYSCVC----GQEKTSATLNVKALPPRFIEDLRSQEATEGTMATLRCQ-MSKAAP-VEWR 3975

  Fly   278 KDLTYLNENNTDPERFSLMENGT---LEIRNVRPEDEGRYGCTIGS----------------SAG 323
            |.    :|...|..|:||.::|.   |:|.::..||.|:|.|..|.                :.|
Mouse  3976 KG----SETLRDGGRYSLRQDGAVCELQIHDLDVEDAGQYSCVCGQEKTSAVLTVDALPPKFTEG 4036

  Fly   324 LKRED------VLLVLKSSKSAS 340
            ||:|:      |.|..:.||.|:
Mouse  4037 LKKEEATEGTMVTLRCQMSKEAT 4059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	30/195 (15%)
		I-set	155..238	CDD:254352	20/92 (22%)
		IGc2	175..228	CDD:197706	14/62 (23%)
		IG_like	250..331	CDD:214653	27/105 (26%)
		IGc2	258..323	CDD:197706	20/83 (24%)
Obscn	NP_001164983.2	I-set	3855..3938	CDD:254352	20/93 (22%)
		IGc2	3868..3926	CDD:197706	15/64 (23%)
		I-set	3943..4026	CDD:254352	22/88 (25%)
		Ig_2	3951..4021	CDD:290606	22/75 (29%)
		I-set	4031..4114	CDD:254352	9/29 (31%)
		IGc2	4044..4102	CDD:197706	5/16 (31%)
		I-set	4119..4202	CDD:254352
		I-set	4208..4291	CDD:254352
		ig	4211..4279	CDD:278476
		I-set	4297..4380	CDD:254352
		Ig	4313..4381	CDD:143165
		I-set	4385..4471	CDD:254352
		Ig	4399..4464	CDD:299845
		I-set	4478..4563	CDD:254352
		Ig	4490..4547	CDD:299845
		I-set	4566..4654	CDD:254352
		I-set	4660..4745	CDD:254352
		FN3	4749..4834	CDD:238020
		I-set	4862..4923	CDD:254352
		I-set	5127..5217	CDD:254352
		Ig	5144..5213	CDD:143165
		I-set	5357..5447	CDD:254352
		Ig	5375..5444	CDD:143165
		I-set	5489..5579	CDD:254352
		Ig	5513..5579	CDD:299845
		Ig	5599..5695	CDD:299845
		I-set	5600..5695	CDD:254352
		SH3_Obscurin_like	5831..5893	CDD:212958
		RhoGEF	5926..6102	CDD:295373
		PH_Obscurin	6111..6235	CDD:270059
		I-set	6243..6335	CDD:254352
		Ig	8..90	CDD:299845
		I-set	9..98	CDD:254352
		I-set	109..200	CDD:254352
		Ig	126..190	CDD:143165
		IG	246..326	CDD:214652
		Ig	250..319	CDD:299845
		I-set	333..416	CDD:254352
		I-set	423..499	CDD:254352
		FN3	513..600	CDD:238020
		I-set	615..>671	CDD:254352
		IGc2	<732..781	CDD:197706
		IGc2	878..941	CDD:197706
		IGc2	970..1033	CDD:197706
		IGc2	1062..1125	CDD:197706
		IGc2	1154..1217	CDD:197706
		IGc2	1246..1309	CDD:197706
		IGc2	1338..1401	CDD:197706
		IGc2	1430..1493	CDD:197706
		IGc2	1522..1585	CDD:197706
		IGc2	1614..1677	CDD:197706
		IGc2	1706..1769	CDD:197706
		IGc2	1798..1861	CDD:197706
		IGc2	1891..1950	CDD:197706
		I-set	1967..2050	CDD:254352
		Ig	1983..2051	CDD:143165
		I-set	2057..2140	CDD:254352
		IGc2	2069..2132	CDD:197706
		I-set	2147..2229	CDD:254352
		I-set	2324..2406	CDD:254352
		Ig	2331..2395	CDD:299845
		I-set	2449..2530	CDD:254352
		Ig	2464..2531	CDD:143165
		I-set	2626..2709	CDD:254352
Ig	2642..2710	CDD:143165
I-set	2716..2798	CDD:254352
I-set	2804..2887	CDD:254352
Ig	2820..2888	CDD:143165
I-set	2894..>2962	CDD:254352
I-set	2985..3065	CDD:254352
Ig_2	2989..3060	CDD:290606
I-set	3073..3156	CDD:254352
IG	3168..3247	CDD:214652
I-set	3254..3336	CDD:254352
Ig_2	3258..3337	CDD:290606
I-set	3342..3425	CDD:254352
ig	3346..3412	CDD:278476
I-set	3431..3513	CDD:254352
IGc2	3443..3501	CDD:197706
I-set	3519..3601	CDD:254352
IGc2	3531..3589	CDD:197706
I-set	3612..3689	CDD:254352	13/81 (16%)
IGc2	3619..3677	CDD:197706	12/69 (17%)
I-set	3695..>3763	CDD:254352	11/67 (16%)
I-set	3768..3850	CDD:254352	17/89 (19%)
IGc2	3780..3838	CDD:197706	15/65 (23%)
Ig	6260..6327	CDD:143165
IG_like	6349..6427	CDD:214653
IGc2	6350..6418	CDD:197706
I-set	6452..6541	CDD:254352
Ig	6475..6538	CDD:143165
PKc_like	6559..6815	CDD:304357
S_TKc	6562..6815	CDD:214567
IGc2	7540..7606	CDD:197706
FN3	7620..7698	CDD:214495
PKc_like	7732..7988	CDD:304357
S_TKc	7741..7984	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900