DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk2 and dpy

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	69/348 - (19%)
Similarity:	115/348 - (33%)	Gaps:	81/348 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SFEDVSISRGPKSSITIKEQSSLQLPCDYQL-PDGYLQKSSVILRWRKDSKTLRQVELGRMDSTT 92
            |.:..::|..|::..|        ||.|:.: |.......|.     :|..|.|..|.    ||.
  Fly  4552 SADRTTLSESPETPTT--------LPSDFTIRPHSEQTTEST-----RDVPTTRPFEA----STP 4599

  Fly    93 SEPQLETML-----REDSRVALSKDSGALQFTSVLASDAGQYQCQLVIDDSVAASSSSGVLLVIE 152
            |...|||.:     ...:.|.:....|  |.|....:...:::..:.:::|...|.|:......|
  Fly  4600 SPASLETTVPSVTSETTTNVPIGSTGG--QVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPSE 4662

  Fly   153 QLK---FVPQ------------------PTSKNLELGTLSKVHCKAQGTPAPQVKWMRETQLPLP 196
            ..:   .:|.                  ||::..|..|.|....:   |..|.|  ..||...:|
  Fly  4663 SPETPTILPSDSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLE---TTVPSV--TLETTTNVP 4722

  Fly   197 VNVTDQNGTLIFNQVSNEQRGQYTCIASNSQGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAV 261
            :..|.               ||.|...::|..::..|:.:.....|..|.....|.|..|..| .
  Fly  4723 IGSTG---------------GQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPT-T 4771

  Fly   262 IHCQAIGEP--KPTIQWDKDLTYLNENNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGL 324
            :....|..|  :.|.:..:|:.     .|.|...|...:.:||........|......|||:.|
  Fly  4772 LPSDFITRPHSEKTTESTRDVP-----TTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGG- 4830

  Fly   325 KREDVLLVLKSSKSASNSIVTRI 347
                  .|.:.:.|:.:.:.|.|
  Fly  4831 ------QVTEQTTSSPSEVRTTI 4847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	20/96 (21%)
		I-set	155..238	CDD:254352	18/103 (17%)
		IGc2	175..228	CDD:197706	11/52 (21%)
		IG_like	250..331	CDD:214653	18/82 (22%)
		IGc2	258..323	CDD:197706	14/66 (21%)
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	28/144 (19%)
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572	7/29 (24%)
		DUF4758	4581..4754	CDD:292572	37/203 (18%)
		DUF4758	4683..4847	CDD:292572	40/196 (20%)
		DUF4758	4785..4964	CDD:292572	16/75 (21%)
		DUF4696	4841..5385	CDD:292395	2/7 (29%)
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900