DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk2 and HMCN2

DIOPT Version :9

Sequence 1:NP_612571.1 Gene:otk2 / 36284 FlyBaseID:FBgn0267728 Length:433 Species:Drosophila melanogaster
Sequence 2:NP_001278744.1 Gene:HMCN2 / 256158 HGNCID:21293 Length:5079 Species:Homo sapiens


Alignment Length:433 Identity:110/433 - (25%)
Similarity:175/433 - (40%) Gaps:99/433 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GRRRLLGCGLGFFC-----------LIFCSYAAPASFEDVSISRGPKSSITIKEQSSLQLPCDYQ 58
            ||.||...|: :.|           |:..|...|.:|...  .|||:.::.::......|.|:..
Human  3005 GRARLSDSGM-YTCEALNAAGRDQKLVQLSVLVPPAFRQA--PRGPQDAVLVRVGDKAVLSCETD 3066

  Fly    59 -LPDGYLQKSSVILRWRKDSKTLRQVELGRMDSTTSEPQLETMLREDSRVALSKDSGALQFTSVL 122
             ||:       ..:.|.||.:.|...            |....||...|         |:.....
Human  3067 ALPE-------PTVTWYKDGQPLVLA------------QRTQALRGGQR---------LEIQEAQ 3103

  Fly   123 ASDAGQYQCQLVIDDSVAASSSSGVLLVIEQLKFVPQPTSKNLELGTLSKV-------HCKAQGT 180
            .||.|.|.|::   .:||..:.....|.::    || ||.:|.:..|:|:|       .|...|.
Human  3104 VSDKGLYSCKV---SNVAGEAVRTFTLTVQ----VP-PTFENPKTETVSQVAGSPLVLTCDVSGV 3160

  Fly   181 PAPQVKWMRETQLPLPV------NVTDQNGTLIFNQVSNEQRGQYTCIASNSQGQITATVSINVV 239
            |||.|.|:::.   :||      .|..:.|.|..:::...|.|.|||:|.|:|.:......:.|:
Human  3161 PAPTVTWLKDR---MPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVL 3222

  Fly   240 VAPKF---SVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQWDKDLTYLNENNTDPERFSLMENGTL 301
            |||:.   .|..|.  .|.|.....:.|:|.|:|.|.:.|.||.:.|.::.....||.| :.|:|
Human  3223 VAPRIRSSGVAREH--HVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYL-DGGSL 3284

  Fly   302 EIRNVRPEDEGRYGCT----IGSSAGLKREDVLL--VLKSSKSASNSIVTR--IIIVIIC----- 353
            .::.:|..|.|.|.|.    .|..|.|...:||:  .:|.....|.::|:|  .::.::|     
Human  3285 VLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 3349

  Fly   354 ----LAFLYFVLVLGLKVWYRYRRH-------LGKVQLEDGHV 385
                :::|...|.|.|.  .|...|       :.||||.|..:
Human  3350 PPIHVSWLKDGLPLPLS--QRTLLHGSGHTLRISKVQLADAGI 3390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otk2NP_612571.1 IG_like 41..132 CDD:214653 17/91 (19%)
I-set 155..238 CDD:254352 28/95 (29%)
IGc2 175..228 CDD:197706 19/58 (33%)
IG_like 250..331 CDD:214653 25/84 (30%)
IGc2 258..323 CDD:197706 20/68 (29%)
HMCN2NP_001278744.1 VWA_2 39..209 CDD:290253
IG_like 434..513 CDD:214653
Ig 442..503 CDD:299845
IG 524..604 CDD:214652
Ig 534..601 CDD:143165
I-set 608..692 CDD:254352
IGc2 621..684 CDD:197706
IG_like 712..782 CDD:214653
Ig 715..779 CDD:143165
Ig 785..869 CDD:299845
IG 792..879 CDD:214652
I-set 885..972 CDD:254352
IGc2 898..962 CDD:197706
IG 988..1063 CDD:214652
Ig 995..1062 CDD:299845
I-set 1079..1161 CDD:254352
IGc2 1088..1151 CDD:197706
I-set 1165..1246 CDD:254352
IGc2 1179..1236 CDD:197706
IG 1258..1340 CDD:214652
Ig 1266..1340 CDD:299845
IG 1354..1433 CDD:214652
IGc2 1360..1423 CDD:197706
IG 1446..1527 CDD:214652
IGc2 1453..1517 CDD:197706
IG 1540..1620 CDD:214652
Ig 1540..1620 CDD:299845
I-set 1632..1716 CDD:254352
IGc2 1641..1704 CDD:197706
IG 1727..1807 CDD:214652
IGc2 1734..1797 CDD:197706
Ig 1820..1893 CDD:299845
IG_like 1827..1891 CDD:214653
I-set 1895..1975 CDD:254352
Ig 1912..1975 CDD:143165
I-set 1986..2076 CDD:254352
IGc2 2001..2066 CDD:197706
Ig 2079..2169 CDD:299845
I-set 2080..2167 CDD:254352
I-set 2171..2261 CDD:254352
IGc2 2185..2251 CDD:197706
I-set 2273..2355 CDD:254352
Ig 2285..2352 CDD:143165
I-set 2367..2449 CDD:254352
Ig 2379..2449 CDD:299845
Ig 2452..2542 CDD:299845
IG_like 2462..2542 CDD:214653
IG 2558..2638 CDD:214652
IGc2 2565..2628 CDD:197706
IG 2656..2736 CDD:214652
IGc2 2663..2726 CDD:197706
IG_like 2770..2847 CDD:214653
IGc2 2773..2837 CDD:197706
IG 2862..2942 CDD:214652
Ig 2868..2942 CDD:299845
IG_like 2954..3034 CDD:214653 7/29 (24%)
IGc2 2961..3024 CDD:197706 6/19 (32%)
I-set 3038..3129 CDD:254352 25/123 (20%)
IGc2 3056..3119 CDD:197706 19/93 (20%)
I-set 3133..3221 CDD:254352 26/90 (29%)
IGc2 3148..3208 CDD:197706 18/62 (29%)
IG 3234..3318 CDD:214652 26/86 (30%)
IGc2 3240..3306 CDD:197706 20/66 (30%)
IG 3329..3410 CDD:214652 15/64 (23%)
IGc2 3336..3400 CDD:197706 12/57 (21%)
IG_like 3424..3499 CDD:214653
IGc2 3430..3489 CDD:197706
I-set 3503..3590 CDD:254352
IGc2 3518..3580 CDD:197706
I-set 3602..3683 CDD:254352
IGc2 3610..3673 CDD:197706
IG 3693..3774 CDD:214652
Ig 3693..3774 CDD:299845
Ig 3777..3859 CDD:299845
IG 3784..3867 CDD:214652
IG_like 3887..3958 CDD:214653
IGc2 3887..3948 CDD:197706
IG 3968..4048 CDD:214652
Ig 3979..4040 CDD:299845
I-set 4052..4139 CDD:254352
IGc2 4065..4129 CDD:197706
I-set 4143..4228 CDD:254352
IGc2 4157..4218 CDD:197706
I-set 4246..4317 CDD:254352
IGc2 4247..4309 CDD:197706
Ig 4322..4405 CDD:299845
I-set 4323..4409 CDD:254352
G2F 4411..4593 CDD:284812
FXa_inhibition 4652..4687 CDD:291342
EGF_CA 4689..4732 CDD:214542
EGF_CA 4733..4774 CDD:284955
EGF_CA 4776..4815 CDD:284955
EGF_CA 4883..4922 CDD:214542
EGF_CA 4923..4963 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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