DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk2 and him-4

DIOPT Version :9

Sequence 1:NP_612571.1 Gene:otk2 / 36284 FlyBaseID:FBgn0267728 Length:433 Species:Drosophila melanogaster
Sequence 2:NP_001024582.1 Gene:him-4 / 181187 WormBaseID:WBGene00001863 Length:5198 Species:Caenorhabditis elegans


Alignment Length:283 Identity:75/283 - (26%)
Similarity:122/283 - (43%) Gaps:38/283 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 SKTLRQVELGRMDSTTSEPQLETMLREDSRVALSKDSGALQFTSVLASDAGQYQCQLVIDDSVAA 141
            ::|:.:.|:....|..|..:....|...:.:..|:|...::..|...||.|:|.|       .||
 Worm  4243 TETVIKCEIESESSEFSWSKNGVPLLPSNNLIFSEDYKLIKILSTRLSDQGEYSC-------TAA 4300

  Fly   142 SSSSGV-----LLVIEQLKFVPQPTSKNLELGTLSKVHCKAQGTPAPQVKWMRETQLPLPVNV-- 199
            :.:...     |.|....|.:.:|.::.:..|....:.|:|.|.|.|.:.|.::.:|.....|  
 Worm  4301 NKAGNATQKTNLNVGVAPKIMERPRTQVVHKGDQVTLWCEASGVPQPAITWYKDNELLTNTGVDE 4365

  Fly   200 --TDQNGTLIFNQVSNEQRGQYTCIASNSQGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAVI 262
              |.:..::||:.:|..|.|.|||.|.|........:.:.|::.|:. ||....:......|..:
 Worm  4366 TATTKKKSVIFSSISPSQAGVYTCKAENWVASTEEDIDLIVMIPPEV-VPERMNVSTNPRQTVFL 4429

  Fly   263 HCQAIGEPKPTIQWDKDLTYLNENNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKRE 327
            .|.|.|.|:|.|.|.:|.....:||   |::.:: ..||.||||.|:|:|.|.|...|.||.|  
 Worm  4430 SCNATGIPEPVISWMRDSNIAIQNN---EKYQIL-GTTLAIRNVLPDDDGFYHCIAKSDAGQK-- 4488

  Fly   328 DVLLVLKSSKSASNSIVTRIIIV 350
                           |.||.:||
 Worm  4489 ---------------IATRKLIV 4496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otk2NP_612571.1 IG_like 41..132 CDD:214653 12/54 (22%)
I-set 155..238 CDD:254352 22/86 (26%)
IGc2 175..228 CDD:197706 19/56 (34%)
IG_like 250..331 CDD:214653 27/80 (34%)
IGc2 258..323 CDD:197706 24/64 (38%)
him-4NP_001024582.1 IG_like 442..515 CDD:214653
IG 527..605 CDD:214652
Ig 628..694 CDD:319273
I-set 702..789 CDD:369462
I-set 793..881 CDD:369462
Ig 899..974 CDD:386229
I-set 1012..1081 CDD:369462
Ig 1109..1172 CDD:319273
Ig 1196..1263 CDD:319273
IG_like 1277..1358 CDD:214653
I-set 1373..1450 CDD:369462
Ig 1474..1544 CDD:386229
IGc2 1563..1628 CDD:197706
Ig 1651..1732 CDD:386229
Ig 1755..1818 CDD:319273
Ig 1839..1912 CDD:386229
Ig 1930..2002 CDD:386229
IG_like 2014..2095 CDD:214653
Ig 2094..2182 CDD:386229
Ig 2190..2283 CDD:386229
I-set 2296..2380 CDD:369462
Ig 2384..2471 CDD:386229
IGc2 2492..2556 CDD:197706
Ig 2580..2654 CDD:386229
Ig 2686..2753 CDD:319273
IG_like 2768..2850 CDD:214653
I-set 2854..2939 CDD:369462
IG_like 2951..3031 CDD:214653
I-set 3046..3116 CDD:369462
I-set 3127..3213 CDD:369462
Ig 3217..3292 CDD:386229
I-set 3300..3386 CDD:369462
I-set 3396..3472 CDD:369462
I-set 3481..3569 CDD:369462
I-set 3591..3663 CDD:369462
Ig 3667..3762 CDD:386229
Ig 3775..3848 CDD:386229
Ig 3859..3947 CDD:386229
IGc2 3968..4031 CDD:197706
Ig_3 4045..4119 CDD:372822
Ig_3 4136..4210 CDD:372822
Ig <4262..4314 CDD:386229 12/58 (21%)
Ig 4318..4406 CDD:386229 22/87 (25%)
IG_like 4418..4496 CDD:214653 30/98 (31%)
I-set 4570..4654 CDD:369462
I-set 4752..4836 CDD:369462
EGF_CA 4996..5027 CDD:238011
EGF_CA 5034..5076 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I7606
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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