DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk2 and Mag

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001333013.1	Gene:	Mag / 17136	MGIID:	96912	Length:	627	Species:	Mus musculus

Alignment Length:	387	Identity:	85/387 - (21%)
Similarity:	141/387 - (36%)	Gaps:	80/387 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GRRRLLGCGLGF-FCLIFCSYAAPA-----------------SFED---VSISRGPKSSITIKEQ 48
            ||.|||| .||. .|.:..|..:|.                 :|.:   :.|...|...:..:..
Mouse    87 GRSRLLG-DLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVV 150

  Fly    49 SSLQLPCDYQLPDGYLQKSSVILRWRKDSKTLRQVELGRMDSTTSEPQLETMLREDS----RVAL 109
            :..::.....:||...:       .|.:...|....||       ||.:...||||.    :|:|
Mouse   151 AGTEVEVSCMVPDNCPE-------LRPELSWLGHEGLG-------EPTVLGRLREDEGTWVQVSL 201

  Fly   110 SKDSGALQFTSVLASDAGQYQCQLVIDDSVAASSSSGVLLVIEQLKFVPQPTSKNLELGTLSKVH 174
                  |.|.....::..:..||....::.........|    .:|:.|.....|..:..:...|
Mouse   202 ------LHFVPTREANGHRLGCQAAFPNTTLQFEGYASL----DVKYPPVIVEMNSSVEAIEGSH 256

  Fly   175 ----CKAQGTPAPQVKWMRETQLPLPVNVTDQNGTLIFNQVSNEQRGQYTCIASNSQGQITATVS 235
                |.|...|.|.:.|||:..:..  ....::..|...:|:..:.|.|.|:|.|:.||...||.
Mouse   257 VSLLCGADSNPPPLLTWMRDGMVLR--EAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVE 319

  Fly   236 INVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIGEPKP--TIQWDKDL--TYLNENNTDPERFSLM 296
            ::|:.|| :.....|.:...|..|..|.|.....|.|  ||..:|.:  |.:.|:...
Mouse   320 LSVMYAP-WKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQ------- 376

  Fly   297 ENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDV--------LLVLKSSKSASNSIVTRIIIV 350
                ||:..|.|||:|.|.|...:..|.:....        :::|:|..:|:...|..:.:|
Mouse   377 ----LELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVV 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	16/94 (17%)
		I-set	155..238	CDD:254352	22/86 (26%)
		IGc2	175..228	CDD:197706	14/52 (27%)
		IG_like	250..331	CDD:214653	22/92 (24%)
		IGc2	258..323	CDD:197706	19/68 (28%)
Mag	NP_001333013.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		56/264 (21%)
		IgV_CD33	22..137	CDD:409377	12/50 (24%)
		Ig strand B	38..42	CDD:409377
		Ig strand C	56..60	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	65..67
		Ig strand E	100..104	CDD:409377	1/3 (33%)
		Ig strand F	114..119	CDD:409377	0/4 (0%)
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	124..128		0/3 (0%)
		Ig strand G	128..133	CDD:409377	1/4 (25%)
		IgC2_CD33_d2_like	141..235	CDD:409579	20/117 (17%)
		Ig strand B	155..159	CDD:409579	0/3 (0%)
		Ig strand C	171..175	CDD:409579	0/3 (0%)
		Ig strand E	200..204	CDD:409579	2/9 (22%)
		Ig strand F	214..219	CDD:409579	1/4 (25%)
		Ig strand G	229..232	CDD:409579	0/2 (0%)
		Ig_3	239..309	CDD:404760	16/71 (23%)
		Ig strand A	239..242	CDD:409353	1/2 (50%)
		Ig strand A'	248..251	CDD:409353	0/2 (0%)
		Ig strand B	256..264	CDD:409353	2/7 (29%)
		Ig strand C	270..274	CDD:409353	0/3 (0%)
		Ig strand C'	277..280	CDD:409353	0/2 (0%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	4/7 (57%)
		Ig strand G	312..322	CDD:409353	4/9 (44%)
		IG	333..409	CDD:214652	22/86 (26%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000269\|PubMed:9482783	578..627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900