DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk2 and si:dkey-238d18.5

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	XP_009290155.2	Gene:	si:dkey-238d18.5 / 101884711	ZFINID:	ZDB-GENE-131121-374	Length:	1111	Species:	Danio rerio

Alignment Length:	370	Identity:	80/370 - (21%)
Similarity:	129/370 - (34%)	Gaps:	110/370 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DVSISRGPKSSITIKEQSSLQLPC--DYQLPDGYLQKSSVILRWRKDSKTLRQVELGRMDSTTSE 94
            :|.:..||    .:||..|:.|.|  |...|       :....|...:|||.        :..|.
Zfish   794 NVKVVTGP----PVKENESVTLTCSSDSNPP-------ATSYEWFSLNKTLL--------AKGSS 839

  Fly    95 PQLETMLREDSRVALSKDSGALQFTSVLASDAGQYQCQLVIDDSVAASSSS----GVLLVIEQLK 155
            .||         |.:|:.:.|:..|:|               ::...:||.    .||.....:|
Zfish   840 YQL---------VKVSRHTEAISCTAV---------------NTEGRNSSDPHHINVLYPPYNVK 880

  Fly   156 FVPQPTSKNLELGTLSKVHCKAQGT-PAPQVKWMRETQLPLPVNVTDQNGTLIFN----QVSNEQ 215
            .|..|..|..|..||:   |.:... ||...:|.            ..|.||...    |:.|..
Zfish   881 VVTGPPVKENESVTLT---CSSDSNPPATSYEWF------------SLNKTLSAKGSSYQLMNVS 930

  Fly   216 R--GQYTCIASNSQGQITA-TVSINVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQW- 276
            |  ...:|.|.|::|:.:: ...:|::..|  .:..|...:  .|.:.|..|.....|...::|
Zfish   931 RHTEAISCTAINTEGRNSSDPQKLNMLYPP--DIKNESSCQ--SASSTVCVCIVDSNPPSEVKWF 991

  Fly   277 --DKDLTYLNENNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDVLLVLKSSKSA 339
              |...|:|:......:..|:.   |||                   |.|...|.:... :|.|.
Zfish   992 SPDSSKTFLSSRTEIKQSLSIF---TLE-------------------AWLDFPDTVQCF-ASNSV 1033

  Fly   340 SNSIVT-------RIIIVIICLAFLYFVLVLGLKVWYRYRRHLGK 377
            .||.:|       .::.:.:..|....::|:|:.| |..|||.||
Zfish  1034 GNSSITLKAPQNDMVLYIAVVSAVSVLLVVVGILV-YAVRRHCGK 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	19/92 (21%)
		I-set	155..238	CDD:254352	21/90 (23%)
		IGc2	175..228	CDD:197706	13/59 (22%)
		IG_like	250..331	CDD:214653	15/83 (18%)
		IGc2	258..323	CDD:197706	11/67 (16%)
si:dkey-238d18.5	XP_009290155.2	Ig	31..142	CDD:325142
		Ig	146..237	CDD:325142
		Ig_2	252..323	CDD:316418
		Ig	610..691	CDD:325142
		Ig	698..786	CDD:325142
		Ig_2	801..872	CDD:316418	22/113 (19%)
		Ig_3	881..942	CDD:316449	18/75 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910