DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk2 and ptk7

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	XP_031758570.1	Gene:	ptk7 / 100487595	XenbaseID:	XB-GENE-5846944	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	336	Identity:	104/336 - (30%)
Similarity:	157/336 - (46%)	Gaps:	43/336 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EDSRVALSKDSGALQFTSVLASDAGQYQCQLVIDDSVAASSSSGV-----LLVIEQLKFVPQPTS 162
            :|||..:. .:|.|:...|...|...|:|       |:|:.:..:     :.|.|.|||.|.|..
Frog   437 KDSRFEIF-PNGTLKILHVEVYDGITYRC-------VSATPAGAIDAQARVTVQENLKFTPVPRP 493

  Fly   163 KN-LELGTLSKVHCKAQGTPAPQVKWMRETQLPLPVNVTDQNGTLIFNQVSNEQRGQYTCIASNS 226
            :. :||.....|||.|.|...|.::|.:.....||.:|..:.|.|.|..|:....|.||||||||
Frog   494 QQCMELDKEITVHCSATGRQKPLIQWTKGDGSDLPAHVESKAGLLHFQPVTRRDAGNYTCIASNS 558

  Fly   227 -QGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQWDK-----DLTYLNE 285
             ||:|.|.|.:.|.|...|.:.||. ..|.:..|||:||||.|:|.|.|||..     |:.:.
Frog   559 QQGEIRAAVQLTVAVLISFKIEPEN-TTVYQGHTAVLHCQAGGDPTPRIQWQSRDVMVDVKHY-- 620

  Fly   286 NNTDPERFSLMENGTLEIRNVRPEDEGRYGCTIGSSAGLKREDVLLVL------KSSKSASNSIV 344
                 .|..:|.||:|.|..|..||.|:|.|..|::..:|..|..|.:      .:|::.|...:
Frog   621 -----PRIQIMPNGSLAIYRVSNEDAGKYTCIAGNACDIKHRDTFLYVVDKPPGGASETDSPYKL 680

  Fly   345 TRIIIVIICLAFLYFVLVLGLKVWYRYRRHLGKVQLEDGH------VNGPT---DGQEHDHHENE 400
            .:.|::.:..|..|.::||||.::.:.||...:....:|.      :||.|   :||.......|
Frog   681 IQTIVLSVVAAVTYIIIVLGLMLYCKKRRKARRRDKPEGEEPEMECLNGGTLLQNGQTTAEIPEE 745

  Fly   401 PCLTEANSSKN 411
            ..||...:.::
Frog   746 VPLTTLGNKRH 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	8/28 (29%)
		I-set	155..238	CDD:254352	34/84 (40%)
		IGc2	175..228	CDD:197706	21/53 (40%)
		IG_like	250..331	CDD:214653	30/85 (35%)
		IGc2	258..323	CDD:197706	27/69 (39%)
ptk7	XP_031758570.1	Ig_3	23..94	CDD:404760
		Ig strand B	38..42	CDD:409353
		Ig strand C	51..55	CDD:409353
		Ig strand E	72..76	CDD:409353
		Ig strand F	87..92	CDD:409353
		Ig	118..211	CDD:416386
		Ig strand B	135..139	CDD:409353
		Ig strand C	148..152	CDD:409353
		Ig strand E	172..176	CDD:409353
		Ig strand F	186..191	CDD:409353
		Ig strand G	198..201	CDD:409353
		IG_like	220..293	CDD:214653
		Ig strand A'	222..225	CDD:409353
		Ig strand B	231..238	CDD:409353
		Ig strand C	244..250	CDD:409353
		Ig strand C'	252..254	CDD:409353
		Ig strand D	260..264	CDD:409353
		Ig strand E	267..272	CDD:409353
		Ig strand F	280..288	CDD:409353
		Ig	317..391	CDD:416386
		Ig strand B	322..331	CDD:409353
		Ig strand C	335..341	CDD:409353
		Ig strand C'	343..345	CDD:409353
		Ig strand E	357..363	CDD:409353
		Ig strand F	369..378	CDD:409353
		Ig strand G	381..391	CDD:409353
		Ig strand A	395..397	CDD:409353
		Ig strand A'	399..405	CDD:409353
		IG_like	401..481	CDD:214653	11/51 (22%)
		Ig strand B	412..419	CDD:409353
		Ig strand C	425..430	CDD:409353
		Ig strand C'	432..435	CDD:409353
		Ig strand D	440..444	CDD:409353	1/3 (33%)
		Ig strand F	460..468	CDD:409353	3/14 (21%)
		Ig strand G	471..482	CDD:409353	0/10 (0%)
		Ig_3	490..557	CDD:404760	23/66 (35%)
		Ig strand B	503..507	CDD:409353	1/3 (33%)
		Ig strand C	516..520	CDD:409353	0/3 (0%)
		Ig strand E	536..540	CDD:409353	2/3 (67%)
		Ig strand F	550..555	CDD:409353	3/4 (75%)
		Ig strand G	564..567	CDD:409353	1/2 (50%)
		Ig	577..650	CDD:416386	30/80 (38%)
		Ig strand A'	583..586	CDD:409353	0/3 (0%)
		Ig strand B	592..599	CDD:409353	5/6 (83%)
		Ig strand C	605..610	CDD:409353	3/4 (75%)
		Ig strand C'	612..614	CDD:409353	0/1 (0%)
		Ig strand D	622..626	CDD:409353	1/3 (33%)
		Ig strand E	629..634	CDD:409353	2/4 (50%)
		Ig strand F	642..650	CDD:409353	3/7 (43%)
		PTK_CCK4	764..1034	CDD:133178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245153at33208
OrthoFinder	1	1.000	-	-		FOG0007317
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010