DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk2 and zgc:172106

DIOPT Version :9

Sequence 1:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001108035.2	Gene:	zgc:172106 / 100136844	ZFINID:	ZDB-GENE-080204-42	Length:	396	Species:	Danio rerio

Alignment Length:	445	Identity:	91/445 - (20%)
Similarity:	167/445 - (37%)	Gaps:	119/445 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FCLIF----------CSYAAPASFEDVSISRGPKSSITIKEQSSLQLPCDYQLPDGYLQKSSVIL 71
            |||.|          ||......:.        |::|.:.:.|:::|...|:.||| |..:.:.
Zfish     2 FCLSFIISLLMIPGICSQKWEVRYS--------KTAICVLKGSTMRLSGSYKHPDG-LTVTEIF- 56

  Fly    72 RWRKDSKTLRQVEL-------GRMDSTTSEPQLETMLREDSRVALSKDSGALQFTSVLASDAGQY 129
             |..:.:..:.:.|       ||:|..    |:|.|.             .|:.::|...|.|.|
Zfish    57 -WTVNIEKGKAINLLNNPNYTGRVDYF----QIEEMF-------------FLKLSNVRHEDEGMY 103

  Fly   130 QCQLVIDDSVAASSSSGVLLVIEQLKFVPQP----TSKNLELGTLSKVHCKAQGTPAPQVKWMRE 190
            ..::...              :|:.:|:..|    |..:|.:.|.::|   .:| .:|.:.....
Zfish   104 CIRIETK--------------VEKQQFLGFPGIELTVTDLRVETPAEV---VEG-DSPVLTCKSS 150

  Fly   191 TQLPLPVNVTDQNG----------TLIFNQVSNEQRGQYTCIASNSQGQITATVSINVVVAPK-F 244
            ..|...:.:..:||          .||...||:|..|.|:|...:.:...:..:::|:...|| .
Zfish   151 CNLGSTIFIWYKNGKSFSESVRQNQLILQSVSSEDSGNYSCAVRDLKDLPSPALTLNIRYPPKSV 215

  Fly   245 SVPPEGPIEVAEAGTAVIHCQAIGEPKPTIQWDKDLTYLNENNTDPERFSLMENG-TLEIRNVRP 308
            ||...|...:....:..:.|.:...| |.:    :.|:..||.:     |.:.:| :..|.:...
Zfish   216 SVSVSGSAVIESGDSVTLSCSSDSNP-PAV----NFTWFKENQS-----SAVGSGQSFSISSFNS 270

  Fly   309 EDEGRYGCTIGSSAGLKR-EDVLLVLKSSKSASNSIVTRIIIVIICLAFLY-FVLVLGLKVWYRY 371
            ...|:|.|...:..|.:| |.|.:.:|.|.|...||...    |...||:: |::::..:|
Zfish   271 SHSGQYYCEAENKYGSQRSESVSVTVKESGSFWISITAG----IAASAFVFVFIVIIRKRV---- 327

  Fly   372 RRHLGKVQLEDGHVNGPTDGQEHDHHENEP-------------CLTEANSSKNLK 413
                  .:.|:.:..|....|:..|...||             | :|.::..|||
Zfish   328 ------TRSEEQNHRGSQQQQQQKHSAVEPPEDPYMALDPNSRC-SEYDTLDNLK 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk2	NP_612571.1	IG_like	41..132	CDD:214653	21/97 (22%)
		I-set	155..238	CDD:254352	19/96 (20%)
		IGc2	175..228	CDD:197706	13/62 (21%)
		IG_like	250..331	CDD:214653	17/82 (21%)
		IGc2	258..323	CDD:197706	12/65 (18%)
zgc:172106	NP_001108035.2	IG_like	32..126	CDD:214653	23/127 (18%)
		Ig	32..110	CDD:299845	20/97 (21%)
		ig	131..195	CDD:278476	15/67 (22%)
		IG_like	136..195	CDD:214653	14/62 (23%)
		Ig_2	228..296	CDD:290606	16/77 (21%)
		IG_like	228..296	CDD:214653	16/77 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900