DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and CD22

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001762.2	Gene:	CD22 / 933	HGNCID:	1643	Length:	847	Species:	Homo sapiens

Alignment Length:	782	Identity:	166/782 - (21%)
Similarity:	252/782 - (32%)	Gaps:	304/782 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RVPQSQSVV-ENESVKFECESTDSYSE-LHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTEDVG 91
            :|..|.::| |.:||...||.:.|..| ....||.:|..:   |:.:....||. |..:  :..|
Human   247 KVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSL---KKQNTFTLNLR-EVTK--DQSG 305

  Fly    92 NYVCIATNLASGAREASPPAKLSVIYL-ESASVQLLGSNRNELLLKCHVEGASGDL--------E 147
            .|.|..:|.....|  |....|.|.|. |.::||:|.|..        |||:..:.        .
Human   306 KYCCQVSNDVGPGR--SEEVFLQVQYAPEPSTVQILHSPA--------VEGSQVEFLCMSLANPL 360

  Fly   148 PLEIEWYRNSEKLS--TWKNVQLDQ----HRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQ 206
            |....||.|.:::.  |.:.|.:.:    |.           |.|.|.|.|..|  ..::|...:
Human   361 PTNYTWYHNGKEMQGRTEEKVHIPKILPWHA-----------GTYSCVAENILG--TGQRGPGAE 412

  Fly   207 SSVKCLPR---------LPRRKNEKMMES-----------------------------------W 227
            ..|:..|:         :|.|:.:.:..|                                   |
Human   413 LDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGW 477

  Fly   228 DKQTFLCRGKRGGAAGLEALPA------APEDLRIVQ-GPIGQSIIKEGEPTALTCLYEL--PDE 283
            |..|..|.......:.  |.|.      ||.|:|:.: .|:.:  |..|...:|.|.:..  |.|
Human   478 DNTTIACAACNSWCSW--ASPVALNVQYAPRDVRVRKIKPLSE--IHSGNSVSLQCDFSSSHPKE 538

  Fly   284 LKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASD 348
                 :|..|.|:|:||                  ||::               .|:|.||...|
Human   539 -----VQFFWEKNGRLL------------------GKES---------------QLNFDSISPED 565

  Fly   349 AGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVR 413
            ||.|.|.        :|:|.|            |..||...|:.:.|....:...:|..||.
Human   566 AGSYSCW--------VNNSIG------------QTASKAWTLEVLYAPRRLRVSMSPGDQVM--- 607

  Fly   414 DGENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPI 478
            :|::.||.  .|.|||..:          .:||....|:|
Human   608 EGKSATLT--CESDANPPV----------SHYTWFDWNNQ------------------------- 635

  Fly   479 ETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCT 543
                                      .|.|.|:.              |.:..|:|:..|:|.|.
Human   636 --------------------------SLPYHSQK--------------LRLEPVKVQHSGAYWCQ 660

  Fly   544 IGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVV-GLMLWCRYRR 607
            ..||.|..|..    :.|....::||..|       |.|.:.:...||.::|.: ||.|..|::|
Human   661 GTNSVGKGRSP----LSTLTVYYSPETIG-------RRVAVGLGSCLAILILAICGLKLQRRWKR 714

  Fly   608 QARKARLNDLSTKEAGGDQPDVAG-----NGKGSEQEPCLSKQH----------NGHSKSRSK-- 655
                       |:...|.|.:.:|     ..|...:.|.....|          :|.|.:..:
Human   715 -----------TQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFP 768

  Fly   656 -----SSGDAQKS---------DDTACSQQSRASKKSAHIYEQLALP----RSGL--SELIQIGR 700
                 .:|||:.|         |||.  ..|...|:....||.: :|    ..|:  |||||.|.
Human   769 EMNIPRTGDAESSEMQRPPPDCDDTV--TYSALHKRQVGDYENV-IPDFPEDEGIHYSELIQFGV 830

  Fly   701 GE 702
            ||
Human   831 GE 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	24/87 (28%)
		Ig	31..115	CDD:299845	23/85 (27%)
		IGc2	133..195	CDD:197706	15/75 (20%)
		Ig	268..373	CDD:299845	25/106 (24%)
		Ig	395..460	CDD:143165	15/64 (23%)
		I-set	468..559	CDD:254352	13/90 (14%)
		IGc2	484..549	CDD:197706	11/64 (17%)
		PTK_CCK4	686..1026	CDD:133178	10/23 (43%)
		STYKc	692..1020	CDD:214568	8/13 (62%)
CD22	NP_001762.2	Ig	24..122	CDD:299845
		C2-set_2	143..228	CDD:285423
		I-set	242..327	CDD:254352	24/87 (28%)
		IGc2	257..316	CDD:197706	18/64 (28%)
		Ig_3	335..400	CDD:290638	18/83 (22%)
		IG_like	343..415	CDD:214653	17/92 (18%)
		IG_like	433..501	CDD:214653	8/69 (12%)
		I-set	510..589	CDD:254352	31/138 (22%)
		IGc2	521..578	CDD:197706	24/102 (24%)
		IG_like	606..677	CDD:214653	26/154 (17%)
		IGc2	608..666	CDD:197706	22/134 (16%)
		ITIM motif 1	760..765		1/4 (25%)
		ITIM motif 2	794..799		1/6 (17%)
		ITIM motif 3	820..825		1/4 (25%)
		ITIM motif 4	840..845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900