DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and IL18R1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_003846.1	Gene:	IL18R1 / 8809	HGNCID:	5988	Length:	541	Species:	Homo sapiens

Alignment Length:	405	Identity:	86/405 - (21%)
Similarity:	152/405 - (37%)	Gaps:	105/405 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 IKEGEPTALT-CLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDAR 329
            :.||||..|. |...|..|:  :.....|.|.......|||..                 |..:|
Human    30 VVEGEPFYLKHCSCSLAHEI--ETTTKSWYKSSGSQEHVELNP-----------------RSSSR 75

  Fly   330 LVLHKQNGTLSFASIIASDAGQYQCQ------------LQLEAHAPINSSPGILEVIEQLKFVPQ 382
            :.||  :..|.|..:..:|.|.|..|            ::...|:.........:::|..||. |
Human    76 IALH--DCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFF-Q 137

  Fly   383 PTSKNLELDAVVAKV----HCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRG 443
            .|.:|.....:|...    :||.        ..:.:.:|.|             |.:|...|.:|
Human   138 ITCENSYYQTLVNSTSLYKNCKK--------LLLENNKNPT-------------IKKNAEFEDQG 181

  Fly   444 NYTCL-ATNSQGQI-NATVAINV-VVTPKFSVPPV--GP------IETSEQGTVVMHCQAIGDPK 497
            .|:|: ..:..|:: |.|...|: :|..:.::.||  ||      :|..:  .|.::|.|:.:.:
Human   182 YYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGK--NVRLNCSALLNEE 244

  Fly   498 PTIQWDKDLKYLSENNTD-----RERFRFL--ENGTLEIRNVQVEDEGS------YGCTIGNSAG 549
            ..|.|    .:..||.:|     .:..|.:  |......:.:::|:.|.      |.||:.::.|
Human   245 DVIYW----MFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGG 305

  Fly   550 LKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLV-------VGLMLWCRYRR 607
            ...:...||.|.       :.:...|.:.||.::|.:.:.:|.:.||       |.|:|:.|:..
Human   306 TDTKSFILVRKA-------DMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLT 363

  Fly   608 QARKARLNDLSTKEA 622
            : |...|.|..|.:|
Human   364 R-RDETLTDGKTYDA 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	24/117 (21%)
		Ig	395..460	CDD:143165	12/70 (17%)
		I-set	468..559	CDD:254352	22/111 (20%)
		IGc2	484..549	CDD:197706	15/77 (19%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
IL18R1	NP_003846.1	Ig	28..100	CDD:325142	22/90 (24%)
		Ig	129..208	CDD:325142	21/100 (21%)
		PHA02785	<171..312	CDD:333475	32/146 (22%)
		TIR	378..520	CDD:307630	86/405 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910