DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and IL18RAP

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_001380415.1 Gene:IL18RAP / 8807 HGNCID:5989 Length:599 Species:Homo sapiens


Alignment Length:357 Identity:71/357 - (19%)
Similarity:130/357 - (36%) Gaps:82/357 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   338 TLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDA---------V 393
            ||.|.:...:::|.|.|:.::     |.|...:...::.:..|...|:.:.|..|         .
Human   110 TLHFLTPGVNNSGSYICRPKM-----IKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGS 169

  Fly   394 VAKVHCKA----QGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATN--- 451
            ...:.|.:    ....:|.|.|.::|:      .:.|:.:..::...|...|:|.|.|..|.   
Human   170 TGSISCPSLSCQSDAQSPAVTWYKNGK------LLSVERSNRIVVDEVYDYHQGTYVCDYTQSDT 228

  Fly   452 -SQGQINATVAINVVV-TPKFSVPPVGPIETS---EQG-TVVMHCQA-IGDPK---PTIQW---D 503
             |...:.|.|.:..:| ..|.....:.|:|.:   |.| .:.:.|:| .|..:   |.|:|   |
Human   229 VSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKD 293

  Fly   504 KDLKY---LSENNTDRERFR--FLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTG 563
            .||::   :.|..:.:...:  .:|...:..:..|.:....:.|.:.||.|...:.|||      
Human   294 SDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL------ 352

  Fly   564 DGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLML---WCR----YRRQARKARLNDLSTKE 621
                 :|..|    |....::..|:.....||....:|   |..    ||....|        .:
Human   353 -----KEKRG----VVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSK--------DQ 400

  Fly   622 AGGDQPD-------VAGNGKGSEQEPCLSKQH 646
            ..||:.|       ...:...||....||::|
Human   401 TLGDKKDFDAFVSYAKWSSFPSEATSSLSEEH 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352
Ig 31..115 CDD:299845
IGc2 133..195 CDD:197706
Ig 268..373 CDD:299845 8/34 (24%)
Ig 395..460 CDD:143165 14/72 (19%)
I-set 468..559 CDD:254352 24/106 (23%)
IGc2 484..549 CDD:197706 16/77 (21%)
PTK_CCK4 686..1026 CDD:133178
STYKc 692..1020 CDD:214568
IL18RAPNP_001380415.1 Ig_6 100..155 CDD:408247 10/49 (20%)
Ig 162..>221 CDD:416386 10/64 (16%)
Ig strand A 162..166 CDD:409353 0/3 (0%)
Ig strand B 171..175 CDD:409353 0/3 (0%)
Ig strand C 188..193 CDD:409353 2/4 (50%)
Ig strand C' 196..198 CDD:409353 0/7 (0%)
Ig strand E 204..209 CDD:409353 0/4 (0%)
Ig 251..354 CDD:416386 23/113 (20%)
Ig strand A 251..254 CDD:409353 0/2 (0%)
Ig strand A' 262..265 CDD:409353 0/2 (0%)
Ig strand B 267..276 CDD:409353 1/8 (13%)
Ig strand C 285..290 CDD:409353 2/4 (50%)
Ig strand D 300..308 CDD:409353 1/7 (14%)
Ig strand E 315..323 CDD:409353 1/7 (14%)
Ig strand F 334..340 CDD:409353 1/5 (20%)
Ig strand G 344..350 CDD:409353 1/5 (20%)
TIR 419..559 CDD:396246 5/14 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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