DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and HMCN1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_114141.2	Gene:	HMCN1 / 83872	HGNCID:	19194	Length:	5635	Species:	Homo sapiens

Alignment Length:	706	Identity:	169/706 - (23%)
Similarity:	260/706 - (36%)	Gaps:	205/706 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQI--GSNLHI-EAVRRTED 89
            |..|....|:.|..:...||:|.:.|.. ..|...|..:....|.|.:  ...|.| .|||  ||
Human  3991 QPQPSELHVILNNPILLPCEATGTPSPF-ITWQKEGINVNTSGRNHAVLPSGGLQISRAVR--ED 4052

  Fly    90 VGNYVCIATNLASGA-----------REASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGAS 143
            .|.|:|:|.|.|..|           ...||..|..||.::           ..:.|.|..:|
Human  4053 AGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVD-----------KPITLSCEADG-- 4104

  Fly   144 GDLEPLEIEWYRNSEKLSTWKNVQLDQHRLI--------IRQPGSEDDGLYRCTASNAAG----- 195
              |.|.:|.|:::...:     |:..:.|::        ..|||  |.|.|.|.|:|.||
Human  4105 --LPPPDITWHKDGRAI-----VESIRQRVLSSGSLQIAFVQPG--DAGHYTCMAANVAGSSSTS 4160

  Fly   196 ---------RVMSKQGY--VYQSSVKCLP----RLPRRKNEKMMESWDKQTFLCRGKRG------ 239
                     |:.|.:|:  |.::|...||    .:|     ....:|.|...|.....|
Human  4161 TKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIP-----TPAINWKKDNVLLANLLGKYTAEP 4220

  Fly   240 -GAAGLE-------------ALPAAPEDLRIVQGPI----------GQSIIKEGEPTALTCL--- 277
             |...||             |..||.||...|...:          |...:.:||...|:|.
Human  4221 YGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATG 4285

  Fly   278 YELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFA 342
            ..||        :|.|..:..:           ||.| |||     :...:.||:.:
Human  4286 IPLP--------KLTWTFNNNI-----------IPAH-FDS-----VNGHSELVIER-------- 4317

  Fly   343 SIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQP-------TSKNLELDAVVAKVHCK 400
             :...|:|.|.|..:        :|.|.::.| ...:|.:|       .|..:|.....|.::|:
Human  4318 -VSKEDSGTYVCTAE--------NSVGFVKAI-GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE 4372

  Fly   401 AQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVV 465
            .:|.|||.:||.|.|.:..:...:....||:|......:|..|:|||:|||..|.:..::::.:.
Human  4373 VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQ 4437

  Fly   466 VTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIR 530
            ..|..::.||..: .:..|.::::|||.|:|:|||.|.:....:|.:    :|...|.|.:|.|.
Human  4438 SPPIITLEPVETV-INAGGKIILNCQATGEPQPTITWSRQGHSISWD----DRVNVLSNNSLYIA 4497

  Fly   531 NVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVL 595
            :.|.||...:.|...|..|.....|.::|:..| ||:.       :...||..:|
Human  4498 DAQKEDTSEFECVARNLMGSVLVRVPVIVQVHG-GFSQ-------WSAWRACSVT---------- 4544

  Fly   596 VVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGK---GSEQE-------PC 641
                   |....|.|....|          ||..|..||   ||:.|       ||
Human  4545 -------CGKGIQKRSRLCN----------QPLPANGGKPCQGSDLEMRNCQNKPC 4583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	29/100 (29%)
		Ig	31..115	CDD:299845	28/97 (29%)
		IGc2	133..195	CDD:197706	18/69 (26%)
		Ig	268..373	CDD:299845	22/107 (21%)
		Ig	395..460	CDD:143165	22/64 (34%)
		I-set	468..559	CDD:254352	26/90 (29%)
		IGc2	484..549	CDD:197706	21/64 (33%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
HMCN1	NP_114141.2	VWA_2	42..212	CDD:290253
		IG_like	440..512	CDD:214653
		Ig	451..510	CDD:299845
		IG	526..608	CDD:214652
		IGc2	533..593	CDD:197706
		I-set	612..696	CDD:254352
		Ig	626..696	CDD:299845
		IG	708..789	CDD:214652
		Ig	720..786	CDD:143165
		Ig	792..884	CDD:299845
		I-set	793..884	CDD:254352
		I-set	890..977	CDD:254352
		IGc2	903..967	CDD:197706
		Ig	980..1071	CDD:299845
		IG	1086..1167	CDD:214652
		Ig	1086..1167	CDD:299845
		I-set	1171..1258	CDD:254352
		Ig	1188..1256	CDD:299845
		Ig	1261..1357	CDD:299845
		IG_like	1276..1355	CDD:214653
		IG_like	1369..1448	CDD:214653
		IGc2	1382..1438	CDD:197706
		I-set	1452..1542	CDD:254352
		Ig	1460..1542	CDD:299845
		IG	1556..1635	CDD:214652
		Ig	1557..1635	CDD:299845
		I-set	1647..1729	CDD:254352
		Ig	1648..1725	CDD:299845
		IGc2	1752..1812	CDD:197706
		IG_like	1843..1915	CDD:214653
		IGc2	1843..1905	CDD:197706
		IG	1929..2008	CDD:214652
		Ig	1934..2008	CDD:299845
		Ig	2031..2092	CDD:299845
		I-set	2111..2191	CDD:254352
		IGc2	2119..2181	CDD:197706
		I-set	2203..2286	CDD:254352
		Ig	<2222..2277	CDD:299845
		IG_like	2299..2380	CDD:214653
		Ig	2299..2370	CDD:299845
		I-set	2391..2474	CDD:254352
		IGc2	2400..2464	CDD:197706
		I-set	2478..2567	CDD:254352
		IGc2	2493..2557	CDD:197706
		I-set	2582..2663	CDD:254352
		IGc2	2594..2653	CDD:197706
		I-set	2681..2762	CDD:254352
		IGc2	2689..2752	CDD:197706
		IG_like	2789..2865	CDD:214653
		IGc2	2791..2855	CDD:197706
		I-set	2879..2960	CDD:254352
		Ig	2879..2950	CDD:299845
		Ig	2963..3054	CDD:299845
		I-set	2970..3052	CDD:254352
		I-set	3066..3147	CDD:254352
		IGc2	3073..3137	CDD:197706
		I-set	3151..3241	CDD:254352
		IGc2	3167..3228	CDD:197706
		Ig	3244..3338	CDD:299845
		I-set	3252..3336	CDD:254352
		I-set	3356..3430	CDD:254352
		IGc2	3357..3420	CDD:197706
		Ig	3433..3523	CDD:299845
		IG_like	3443..3523	CDD:214653
IG_like	3536..3616	CDD:214653
IGc2	3543..3606	CDD:197706
I-set	3628..3709	CDD:254352
IGc2	3636..3699	CDD:197706
I-set	3719..3800	CDD:254352
Ig	3719..3795	CDD:299845
I-set	3804..3893	CDD:254352
Ig	3810..3883	CDD:299845
Ig	3896..3984	CDD:299845
IG_like	3903..3984	CDD:214653
Ig	3987..4067	CDD:299845	25/78 (32%)
IG	3994..4075	CDD:214652	25/83 (30%)
I-set	4079..4165	CDD:254352	25/107 (23%)
IGc2	4093..4155	CDD:197706	18/83 (22%)
Ig	4168..4258	CDD:299845	21/94 (22%)
IG_like	4176..4256	CDD:214653	19/84 (23%)
I-set	4260..4345	CDD:254352	24/127 (19%)
IGc2	4274..4335	CDD:197706	21/102 (21%)
IG	4356..4435	CDD:214652	24/78 (31%)
Ig	4356..4435	CDD:299845	24/78 (31%)
I-set	4440..4526	CDD:254352	26/90 (29%)
Ig	4443..4521	CDD:299845	24/82 (29%)
TSP1	4533..4584	CDD:214559	17/85 (20%)
TSP1	4589..4641	CDD:214559
TSP1	4646..4698	CDD:214559
TSP1	4703..4755	CDD:214559
TSP1	4760..4812	CDD:214559
TSP1	4817..4869	CDD:214559
G2F	4868..5092	CDD:214774
EGF_CA	5107..5146	CDD:214542
EGF_CA	5147..5190	CDD:284955
EGF_CA	5192..5228	CDD:214542
EGF_CA	5230..5263	CDD:238011
EGF_CA	5272..5313	CDD:284955
EGF_CA	5315..5354	CDD:214542
EGF_CA	5432..5471	CDD:214542
EGF_CA	5472..5508	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10357
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810