DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and THE1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_200249.1	Gene:	THE1 / 835526	AraportID:	AT5G54380	Length:	855	Species:	Arabidopsis thaliana

Alignment Length:	812	Identity:	169/812 - (20%)
Similarity:	291/812 - (35%)	Gaps:	221/812 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 APIPGHSFD--SGKDALLREDARLV----LHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSS 367
            :||...:::  |....::.||..|:    .:..||:..|.....:...::   |.| :..|.|:|
plant   110 SPINNSTWNLTSASITVVTEDFVLLNNFSFNNFNGSYIFKEYTVNVTSEF---LTL-SFIPSNNS 170

  Fly   368 PGILEVIEQLKFVPQPTSKNLELDAVVA----------------KVHCKAQGTP-------TPQV 409
            ...:..||.:. ||.    ||..|..:|                .|:....|.|       |...
plant   171 VVFVNAIEVVS-VPD----NLIPDQALALNPSTPFSGLSLLAFETVYRLNMGGPLLTSQNDTLGR 230

  Fly   410 QWVRDGENTTLPDHVEVDANGTLIFRN---------VNSEHRGNYTCLATNSQGQINATVAINVV 465
            ||..|.|      ::.|:::..::..|         |..|...|......::.|..|       |
plant   231 QWDNDAE------YLHVNSSVLVVTANPSSIKYSPSVTQETAPNMVYATADTMGDAN-------V 282

  Fly   466 VTPKFSVPPVGPIETSEQGTVVMH-CQAIGDPKPTIQWD-----------KDLKYLSENNTDRER 518
            .:|.|:|..|.|::...:..|.:| |..:.....|:.::           .||..|: |......
plant   283 ASPSFNVTWVLPVDPDFRYFVRVHFCDIVSQALNTLVFNLYVNDDLALGSLDLSTLT-NGLKVPY 346

  Fly   519 FR-FLENGTLE---IRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGD-----GFAPEES--- 571
            |: |:.||::|   :..|.|..:.....|.....||:      |:|.:.:     |.:..:|
plant   347 FKDFISNGSVESSGVLTVSVGPDSQADITNATMNGLE------VLKISNEAKSLSGVSSVKSLLP 405

  Fly   572 GGDGF-LVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKG 635
            ||.|. ...:||:|...|....::|::.:..:|..           :::::.....|...|||
plant   406 GGSGSKSKKKAVIIGSLVGAVTLILLIAVCCYCCL-----------VASRKQRSTSPQEGGNG-- 457

  Fly   636 SEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGR 700
               .|.|.....|.|::.:||:. :.||...:|...:........:::::....:...|...:|.
plant   458 ---HPWLPLPLYGLSQTLTKSTA-SHKSATASCISLASTHLGRCFMFQEIMDATNKFDESSLLGV 518

  Fly   701 GEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEE 765
            |.||.|:.|.|                      |:|:
plant   519 GGFGRVYKGTL----------------------EDGT---------------------------- 533

  Fly   766 IKEEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYM 830
                            .|.||..|. :.||...|||.::::|..:.|:.:|.|.|.|.|:....:
plant   534 ----------------KVAVKRGNP-RSEQGMAEFRTEIEMLSKLRHRHLVSLIGYCDERSEMIL 581

  Fly   831 VLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRA---RFTHRD 892
            |.||...|.|:..|.            .:..|||:..|.|.:....|||:..::..   ...|||
plant   582 VYEYMANGPLRSHLY------------GADLPPLSWKQRLEICIGAARGLHYLHTGASQSIIHRD 634

  Fly   893 LATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLL--PIRWLAPECIQEDEYTTKSDIFAYG 955
            :.|.|.::....:.||:...|.|...|.: ..|.:|.:  ...:|.||..:..:.|.|||::::|
plant   635 VKTTNILLDENLVAKVADFGLSKTGPSLD-QTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFG 698

  Fly   956 VVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVA-----------------EATPDSLR--- 1000
            ||:.|:......|       ..|:.|.|....||::|                 :..|.||:
plant   699 VVLMEVLCCRPAL-------NPVLPREQVNIAEWAMAWQKKGLLDQIMDSNLTGKVNPASLKKFG 756

  Fly  1001 EILLSCWVSNPKERPSFSQLGAALSKAMQSAE 1032
            |....|......:|||...:...|..|:|..|
plant   757 ETAEKCLAEYGVDRPSMGDVLWNLEYALQLEE 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	14/69 (20%)
		Ig	395..460	CDD:143165	16/96 (17%)
		I-set	468..559	CDD:254352	23/106 (22%)
		IGc2	484..549	CDD:197706	16/80 (20%)
		PTK_CCK4	686..1026	CDD:133178	79/364 (22%)
		STYKc	692..1020	CDD:214568	78/352 (22%)
THE1	NP_200249.1	Malectin_like	34..384	CDD:289580	61/302 (20%)
		Malectin	210..382	CDD:288557	37/185 (20%)
		STKc_IRAK	516..781	CDD:270968	77/351 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050