DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and HERK1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_190214.1	Gene:	HERK1 / 823774	AraportID:	AT3G46290	Length:	830	Species:	Arabidopsis thaliana

Alignment Length:	719	Identity:	161/719 - (22%)
Similarity:	267/719 - (37%)	Gaps:	151/719 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 WVR------DGEN---------TTLPDHVEVDANGTLIFRNVNSEHRGNYT-----CLATNSQGQ 455
            |||      |.:|         .:...||.: ::.|:....|..|:..|.|     ...|.|.|.
plant    99 WVRLYFNPFDYQNFKMGSAKFAVSSQSHVLL-SDFTVTSSKVVKEYSLNVTTNDLVLTFTPSSGS 162

  Fly   456 ---INATVAINVVVT-----PKFSVPPVGPIETSEQGTVVMHCQAIGDP-------KPTIQWDKD 505
               :||...|::..|     |:|...|....:.|.||...:|...:|.|       ..|..|..|
plant   163 FAFVNAIEVISIPDTLITGSPRFVGNPAQFPDMSMQGLETIHRVNMGGPLVASNNDTLTRTWVPD 227

  Fly   506 LKYLSENNTDRERFRFLENGTLE-IRNVQVEDEGS---YG-CTIGNSAGLKREDVQLVVKTTGDG 565
            .::|.|.|..:...:|   .|:. :.....||...   || ||..|||    ::...:...|.:
plant   228 SEFLLEKNLAKSMSKF---STVNFVPGYATEDSAPRTVYGSCTEMNSA----DNPNSIFNVTWE- 284

  Fly   566 FAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLST----KEAGGDQ 626
            |..:......|......::::::...|..|.|..|:         .|...||||    ..||...
plant   285 FDVDPGFQYYFRFHFCDIVSLSLNQLYFNLYVDSMV---------AATDIDLSTLVDNTLAGAYS 340

  Fly   627 PD-VAGNGKGSEQ-----EPCLSKQHNGHSKS-------RSKSSGDAQKSDDTACSQQSRASKKS 678
            .| |....|||.:     .|  |..|..:..:       ...::...|.|..|.....|.:||.:
plant   341 MDFVTQTPKGSNKVRVSIGP--STVHTDYPNAIVNGLEIMKMNNSKGQLSTGTFVPGSSSSSKSN 403

  Fly   679 AHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGS--GGSG 741
            ..:     :..|.:..|:.:       ||:|............:|..::.....|.||:  |...
plant   404 LGL-----IVGSAIGSLLAV-------VFLGSCFVLYKKRKRGQDGHSKTWMPFSINGTSMGSKY 456

  Fly   742 SGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHN--QSGLEQL----------VLVKALNKVKDE 794
            |..|||:::......:.....:::......:..|  ..|..::          |.||..|. |.:
plant   457 SNGTTLTSITTNANYRIPFAAVKDATNNFDESRNIGVGGFGKVYKGELNDGTKVAVKRGNP-KSQ 520

  Fly   795 QACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSS 859
            |...|||.::::|....|:.:|.|.|.|.|.:...::.||.:.|.:|..|.            .|
plant   521 QGLAEFRTEIEMLSQFRHRHLVSLIGYCDENNEMILIYEYMENGTVKSHLY------------GS 573

  Fly   860 SPPPLTTSQVLAVAYQIARGMDAIYRA---RFTHRDLATRNCVISSEFIVKVSYPALCKDKYSRE 921
            ..|.||..|.|.:....|||:..::..   ...|||:.:.|.::...|:.||:...|.|.....:
plant   574 GLPSLTWKQRLEICIGAARGLHYLHTGDSKPVIHRDVKSANILLDENFMAKVADFGLSKTGPELD 638

  Fly   922 YHKHRNTLL--PIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQA----TKLPHEELTN----- 975
             ..|.:|.:  ...:|.||..:..:.|.|||::::|||::|:....    ..|| .|:.|
plant   639 -QTHVSTAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVLFEVLCARPVIDPTLP-REMVNLAEWA 701

  Fly   976 ---------EQVVQRSQAGSLEWSVAEATPDSLREILLS---CWVSNPKERPSFSQLGAALSKAM 1028
                     :|::.:|..|::.       |||||:...:   |......:|||...:...|..|:
plant   702 MKWQKKGQLDQIIDQSLRGNIR-------PDSLRKFAETGEKCLADYGVDRPSMGDVLWNLEYAL 759

  Fly  1029 QSAE 1032
            |..|
plant   760 QLQE 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845
		Ig	395..460	CDD:143165	17/71 (24%)
		I-set	468..559	CDD:254352	26/102 (25%)
		IGc2	484..549	CDD:197706	20/76 (26%)
		PTK_CCK4	686..1026	CDD:133178	85/379 (22%)
		STYKc	692..1020	CDD:214568	83/367 (23%)
HERK1	NP_190214.1	Malectin_like	33..380	CDD:372329	67/300 (22%)
HERK1	NP_190214.1	STKc_IRAK	491..756	CDD:270968	69/286 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050