DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and Musk

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_112323.2	Gene:	Musk / 81725	RGDID:	3211	Length:	868	Species:	Rattus norvegicus

Alignment Length:	1079	Identity:	234/1079 - (21%)
Similarity:	385/1079 - (35%)	Gaps:	373/1079 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 TNLASGAREASPPAKLSVIYLES--ASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRN---- 156
            |.:|....|..|.|.:....||:  |.|:.:.:      ..|.||...   :| ||.|.||
  Rat    14 TLVAFSGTEKLPKAPVITTPLETVDALVEEVAT------FMCAVESYP---QP-EISWTRNKILI 68

  Fly   157 ---SEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRR 218
               ..:.|..:|.||    |.|......|||:|.|||:|..|..:...|.:   .||..|::.|
  Rat    69 KLFDTRYSIRENGQL----LTILSVEDSDDGIYCCTANNGVGGAVESCGAL---QVKMKPKITR- 125

  Fly   219 KNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDE 283
                                                    .||...|| ||....|.|     ..
  Rat   126 ----------------------------------------PPINVKII-EGLKAVLPC-----TT 144

  Fly   284 LKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASD 348
            :.|.:..:.|.|.                        |:.|||::|:.: .::|:|...::...|
  Rat   145 MGNPKPSVSWIKG------------------------DSALRENSRIAV-LESGSLRIHNVQKED 184

  Fly   349 AGQYQCQLQLEAHAPINSSPGI-------LEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPT 406
            ||||:|..:        :|.|.       |||....:.:..|.|.|:...:.|. :.|.|.|.|.
  Rat   185 AGQYRCVAK--------NSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVT-LRCTAIGMPV 240

  Fly   407 PQVQWVRDG---ENTTLPDHVE---VDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVV 465
            |.:.|:.:|   .:.::.::|:   :|:...|....     .|.|||:|||..|:..:|......
  Rat   241 PTISWIENGNAVSSGSIQENVKDRVIDSRLQLFITK-----PGLYTCIATNKHGEKFSTAKAAAT 300

  Fly   466 VTPKFSVPPVGPIETSEQGTVVMH----CQAI-------------GDPKPTIQ------WDKDLK 507
            |    |:......:...:|....:    |.|:             .||:...:      |: :||
  Rat   301 V----SIAEWSKSQKESKGYCAQYRGEVCDAVLVKDSLVFFNTSYPDPEEAQELLIHTAWN-ELK 360

  Fly   508 YLS--------------------------------------------------ENNTDRERFR-- 520
            .:|                                                  |..|.|..:|
  Rat   361 AVSPLCRPAAEALLCNHLFQECSSGVLPTPMPICREYCLAVKELFCAKEWLAMEGKTHRGLYRSG 425

  Fly   521 --FLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGD--------- 574
              ||.  ..|...:....:....||.......|:|::     ||.......:...|
  Rat   426 MHFLP--VPECSKLPSMHQDPTACTRLPYLDYKKENI-----TTFPSITSSKPSVDIPNLPASTS 483

  Fly   575 GFLVTRAVLITMTVAL-----AYIVLVVGLMLWCRYRRQ----ARKARLNDLSTKEAGGDQPDVA 630
            .|.|:.|..:|:.:::     .:.:|.:..:..||.||:    .|::....|:|..:
  Rat   484 SFAVSPAYSMTVIISIMSCFAVFALLTITTLYCCRRRREWKNKKRESAAVTLTTLPS-------- 540

  Fly   631 GNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLAL-------- 687
                    |..|.:.|..                               .:|:::.|
  Rat   541 --------ELLLDRLHPN-------------------------------PMYQRMPLLLNPKLLS 566

  Fly   688 ---PRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLST 749
               ||:.:..:..||.|.||.||..:....|...|
  Rat   567 LEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP------------------------------ 601

  Fly   750 LNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKG 814
                    .:|..::.:|||..                    .|.||  :|:|:..|:....:..
  Rat   602 --------FTMVAVKMLKEEAS--------------------ADMQA--DFQREAALMAEFDNPN 636

  Fly   815 VVRLFGLCREKDPHYMVLEYTDWGDLKQFL---------------LATAGKVNTATAGSSSPPPL 864
            :|:|.|:|....|..::.||..:|||.:||               |:|..:|:     |..||||
  Rat   637 IVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVS-----SPGPPPL 696

  Fly   865 TTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNT 928
            :.::.|.:|.|:|.||..:...:|.|||||||||::....:||::...|.::.||.:|:| ..|.
  Rat   697 SCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGND 761

  Fly   929 LLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAE 993
            .:||||:.||.|..:.|||:||::|||||:||:|:...: |:..:.:|:|:...:.|:: .:..|
  Rat   762 AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQ-PYYGMAHEEVIYYVRDGNI-LACPE 824

  Fly   994 ATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSAE 1032
            ..|..|..::..||...|.:||||..:...|.:..:.||
  Rat   825 NCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	5/16 (31%)
		Ig	31..115	CDD:299845	5/16 (31%)
		IGc2	133..195	CDD:197706	23/68 (34%)
		Ig	268..373	CDD:299845	23/111 (21%)
		Ig	395..460	CDD:143165	18/70 (26%)
		I-set	468..559	CDD:254352	21/167 (13%)
		IGc2	484..549	CDD:197706	18/141 (13%)
		PTK_CCK4	686..1026	CDD:133178	101/366 (28%)
		STYKc	692..1020	CDD:214568	97/343 (28%)
Musk	NP_112323.2	IgI_1_MuSK	28..117	CDD:409562	29/105 (28%)
		Ig strand B	45..49	CDD:409562	0/9 (0%)
		Ig strand C	58..62	CDD:409562	2/3 (67%)
		Ig strand E	82..86	CDD:409562	3/7 (43%)
		Ig strand F	96..101	CDD:409562	2/4 (50%)
		Ig strand G	110..113	CDD:409562	0/2 (0%)
		IgI_2_MuSK	122..209	CDD:409560	29/166 (17%)
		Ig strand B	138..142	CDD:409560	1/3 (33%)
		Ig strand C	151..155	CDD:409560	0/3 (0%)
		Ig strand E	173..177	CDD:409560	2/3 (67%)
		Ig strand F	187..192	CDD:409560	3/4 (75%)
		Ig strand G	201..204	CDD:409560	0/2 (0%)
		Ig_3	218..286	CDD:404760	19/73 (26%)
		Ig strand A'	222..225	CDD:409353	1/2 (50%)
		Ig strand B	229..236	CDD:409353	2/7 (29%)
		Ig strand C	242..247	CDD:409353	1/4 (25%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	258..262	CDD:409353	0/3 (0%)
		Ig strand E	268..272	CDD:409353	0/3 (0%)
		Ig strand F	278..286	CDD:409353	5/7 (71%)
		CRD_TK_ROR_related	313..457	CDD:143578	18/146 (12%)
		PTKc_Musk	568..857	CDD:133181	100/355 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810