DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment otk and VWA7

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_079534.2 Gene:VWA7 / 80737 HGNCID:13939 Length:891 Species:Homo sapiens


Alignment Length:498 Identity:92/498 - (18%)
Similarity:155/498 - (31%) Gaps:151/498 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   611 KARLNDLSTKEAGGD-------QPDV------AGNGK----GSEQEPCLSKQHNGHSKSRSKSSG 658
            :|.|.::|...|..|       .||:      .|.|:    |:.:|..::.:...|:.:|.:...
Human   101 RAALGEVSRANAAQDFLPTSRNDPDLHFDAERLGQGRARLVGALRETVVAARALDHTLARQRLGA 165

  Fly   659 DAQKSDD-TACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDV--------FVGKLKAT 714
            ......| .:.|......::..|  ..|..||..|..|.|:......|.        ::|   .|
Human   166 ALHALQDFYSHSNWVELGEQQPH--PHLLWPRQELQNLAQVADPTCSDCEELSCPRNWLG---FT 225

  Fly   715 LVTS-------PSDKDADTEKQH---SNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEE 769
            |:||       |......:...|   |:|:...||....||:...      |...|..::..|  
Human   226 LLTSGYFGTHPPKPPGKCSHGGHFDRSSSQPPRGGINKDSTSPGF------SPHHMLHLQAAK-- 282

  Fly   770 EQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREK--------- 825
                     |..|..::|.:.::.....::|.|.||:..|.|...|:...|...|:         
Human   283 ---------LALLASIQAFSLLRSRLGDRDFSRLLDITPASSLSFVLDTTGSMGEEINAAKIQAR 338

  Fly   826 -----------DP-HYMVLEYTD---------------WGDLKQFLLATAGKVNTATAGSSSP-- 861
                       :| ||:::.:.|               |..|.:.         .|..|...|  
Human   339 HLVEQRRGSPMEPVHYVLVPFHDPGFGPVFTTSDPDSFWQQLNEI---------HALGGGDEPEM 394

  Fly   862 ------------PPLTTSQVLAVAYQIARGMDAIYRARFTHRDLAT----RNCVISSEFIVKVSY 910
                        |||:...|..         ||..:..|....:.:    |.|.::  |:|    
Human   395 CLSALQLALLHTPPLSDIFVFT---------DASPKDAFLTNQVESLTQERRCRVT--FLV---- 444

  Fly   911 PALCKDKYSREYHKHRNTLLPIRWLAPECIQ-----EDEYTTKSDIFAYGVVVWELFNQATKLPH 970
               .:|....:....|..|.|:|:...:.:.     |..:|....|.....:|.|.......||.
Human   445 ---TEDTSRVQGRARREILSPLRFEPYKAVALASGGEVIFTKDQHIRDVAAIVGESMAALVTLPL 506

  Fly   971 EE--LTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNP 1011
            :.  :...|.:..|..|.|:........|     :.|.|:.||
Human   507 DPPVVVPGQPLVFSVDGLLQKITVRIHGD-----ISSFWIKNP 544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352
Ig 31..115 CDD:299845
IGc2 133..195 CDD:197706
Ig 268..373 CDD:299845
Ig 395..460 CDD:143165
I-set 468..559 CDD:254352
IGc2 484..549 CDD:197706
PTK_CCK4 686..1026 CDD:133178 75/405 (19%)
STYKc 692..1020 CDD:214568 73/399 (18%)
VWA7NP_079534.2 Het-C <163..>190 CDD:311270 3/28 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..272 8/40 (20%)
VWA_2 318..418 CDD:316077 16/117 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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