DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and SIGLEC1

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_075556.1	Gene:	SIGLEC1 / 6614	HGNCID:	11127	Length:	1709	Species:	Homo sapiens

Alignment Length:	964	Identity:	190/964 - (19%)
Similarity:	319/964 - (33%)	Gaps:	350/964 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ASSSRFQRVPQSQSVVENESVKFECESTDSYS-ELHYDWLHNGHRIAYDKRVHQ-IGSNLHIEAV 84
            |:::|....|.:: |||.::|...|.|..|.: :..:.|..||      ..:|: .||:|.:.|.
Human   508 ANAARLLISPAAE-VVEGQAVTLSCRSGLSPTPDARFSWYLNG------ALLHEGPGSSLLLPAA 565

  Fly    85 RRTEDVGNYVCIAT--NLASGAREASPPAKLSVIY------------LESASVQLLGSNRNELLL 135
            ..| |.|:|.|.|.  :.|||   .|.||.|:|:|            |::|..   |:.|..|||
Human   566 SST-DAGSYHCRARDGHSASG---PSSPAVLTVLYPPRQPTFTTRLDLDAAGA---GAGRRGLLL 623

  Fly   136 KCHVEGASGDLEPLEIEWYRN--------------------SEKLSTWKNVQLDQHRLIIRQPGS 180
             |.|:..    .|..::....                    |.::...|...|  .|:.|..|..
Human   624 -CRVDSD----PPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNL--LRVEIHNPLL 681

  Fly   181 EDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMME------------------SW 227
            |::|||.|.||||.|...:...:..|::|  |...|....::..|                  ||
Human   682 EEEGLYLCEASNALGNASTSATFNGQATV--LAIAPSHTLQEGTEANLTCNVSREAAGSPANFSW 744

  Fly   228 -----------------------DKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGP--------- 260
                                   |...:.||......|.|    :.|..|.::..|
Human   745 FRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQL----STPVLLSVLYPPDRPKLSALL 805

  Fly   261 -IGQSIIK------EGEPTALTCLYE----LPDELKNQ-----RIQLRWRKDGKLLRQVELG--- 306
             :||..:.      :..|.||..|:.    |...|..|     |.|.:...:...|...|||
Human   806 DMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGD 870

  Fly   307 ------------GSAPI--------------PGHSFDSGKDALLR----------------EDAR 329
                        ||:..              |......|:..:|.                .|.:
Human   871 SGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935

  Fly   330 LVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIE-QLKFVPQPTSKNLELDAV 393
            .:....:.||.||:|..:.||.|.||    |.||.:::..:...|. .:.:.|:..:....:|..
Human   936 PLQESTSATLRFAAITLTQAGAYHCQ----AQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG 996

  Fly   394 VAKVH---CKAQGTPTPQVQWVR---------------DGENTTL-----PDHVEVDANGTLIFR 435
            ..::.   |:....|..|::.:.               :|.:..|     |:.:.::.:|.::
Human   997 PGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAML-- 1059

  Fly   436 NVNSEHRGNYTCLATNSQGQINATV-----AINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGD 495
                |..|.|.|.|:|:.||.:|:.     |:||.|.|..:|         .:|.:|.....:..
Human  1060 ----EDEGVYICEASNTLGQASASADFDAQAVNVQVWPGATV---------REGQLVNLTCLVWT 1111

  Fly   496 PKP---TIQWDKD---------------------------------------------------- 505
            ..|   |..|.:|
Human  1112 THPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLR 1176

  Fly   506 LKYLSENNTDR-------------------ERFRFLENGT---------LEIRNVQVEDEGSYGC 542
            |.||.|::..:                   ...|.|.:.|         ||:|..|..|||.|.|
Human  1177 LTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSC 1241

  Fly   543 TIGNSAG-------LKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLM 600
            :..:..|       |:.|.|::::       |||.:..:|..:|    :|.....|:   ...|.
Human  1242 SARSPLGQANTSLELRLEGVRVIL-------APEAAVPEGAPIT----VTCADPAAH---APTLY 1292

  Fly   601 LWC---RYRRQARKARLNDL-STKEAGGDQPDVAGNGKGSE-------------QEPCLSKQHNG 648
            .|.   |:.::...|.|:.| :|:...|.....|.:.:|:.             |:..||...:.
Human  1293 TWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDS 1357

  Fly   649 HSKSRS--KSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGR 700
            .::|.:  :.:.|::...:.|.|...:....|:.:: .||   ||... :|:.|
Human  1358 RARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVH-SLA---SGTGH-VQVAR 1406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	30/92 (33%)
		Ig	31..115	CDD:299845	29/87 (33%)
		IGc2	133..195	CDD:197706	21/81 (26%)
		Ig	268..373	CDD:299845	32/158 (20%)
		Ig	395..460	CDD:143165	16/87 (18%)
		I-set	468..559	CDD:254352	28/180 (16%)
		IGc2	484..549	CDD:197706	22/147 (15%)
		PTK_CCK4	686..1026	CDD:133178	5/15 (33%)
		STYKc	692..1020	CDD:214568	2/9 (22%)
SIGLEC1	NP_075556.1	Ig	21..136	CDD:299845
		IG_like	26..135	CDD:214653
		Sialic acid binding. /evidence=ECO:0000250	122..126
		C2-set_2	142..228	CDD:285423
		Ig_2	245..323	CDD:290606
		IG_like	247..323	CDD:214653
		Ig	336..408	CDD:299845
		IG_like	338..408	CDD:214653
		Ig	430..503	CDD:143165
		IG_like	431..503	CDD:214653
		Ig_2	514..594	CDD:290606	29/90 (32%)
		IG	516..594	CDD:214652	29/88 (33%)
		IG_like	624..703	CDD:214653	19/84 (23%)
		IG_like	715..792	CDD:214653	11/80 (14%)
		ig	715..788	CDD:278476	9/76 (12%)
		Ig	809..893	CDD:299845	16/83 (19%)
		I-set	898..980	CDD:254352	18/85 (21%)
		Ig_2	900..980	CDD:290606	18/83 (22%)
		Ig	1003..1080	CDD:143165	16/82 (20%)
		Ig_2	1093..1168	CDD:290606	8/83 (10%)
		IG_like	1093..1168	CDD:214653	8/83 (10%)
		I-set	1186..1256	CDD:254352	13/69 (19%)
		Ig_2	1263..1342	CDD:290606	17/92 (18%)
		IG_like	1271..1342	CDD:214653	14/77 (18%)
		Ig	1363..1442	CDD:299845	10/49 (20%)
		IG_like	1455..1529	CDD:214653
		Ig	1457..1518	CDD:299845
		Ig	<1552..1630	CDD:299845
		IG	1552..1627	CDD:214652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810