DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment otk and ntrk2b

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_001184090.2 Gene:ntrk2b / 570240 ZFINID:ZDB-GENE-010126-2 Length:799 Species:Danio rerio


Alignment Length:813 Identity:194/813 - (23%)
Similarity:307/813 - (37%) Gaps:207/813 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 SIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGK--LLRQVELGGSAPIPGHSFDSGKDALLRE 326
            :::..|.|....|        :|..|:| |..|.:  :|:.::.||.|.                
Zfish   136 TLLLSGNPLQCAC--------ENIWIKL-WLDDSERDVLQCLQEGGKAK---------------- 175

  Fly   327 DARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELD 391
                       |||..::                  |:...|       :::..|...|:....|
Zfish   176 -----------TLSRLTL------------------PLCEHP-------RVEVFPTDVSQMAGSD 204

  Fly   392 AVVAKVHCKAQGTPTPQVQW-VRDGENTTLPDHVEV---DANGTLIFRNVNSEHRG-NYTCLATN 451
            |.|.   |.|.|:|||::.| :...|:..|....|:   |....|....::....| ...|.|.|
Zfish   205 ATVI---CNASGSPTPELTWTLNSSEHPPLSTSHEISKMDLQSVLTLNGLSPNDNGRKLICSAEN 266

  Fly   452 SQGQINATVAINVVVTP---KFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENN 513
            ..|||.|||.:|:...|   :..:|     |.|:...:..  ...|:|:|.:.|..:.|.|.|..
Zfish   267 IVGQIEATVMLNISFPPTVLELYLP-----ERSQDWCIPF--VVTGNPRPDLHWYHEGKPLEEQE 324

  Fly   514 TDRERFRFLEN----GTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGD 574
            ..|.....:.|    |.|::........|.|.....|..|..|.:|........|   .:.||.:
Zfish   325 YIRTEIHDITNTEYHGCLKLDTPTHIHNGIYTLVASNEFGEDRGNVTAHFMRIPD---VDHSGIE 386

  Fly   575 GFL------------VTRAVLITMTVALAYIVLV--VGLMLWCRYRRQARKARLNDLSTKEAGGD 625
            |..            :...|.:.:.|.:|.:.|.  :.::::.:|.|.                 
Zfish   387 GVFYYDTTVSPDIPPLEDRVAVYIVVGIAGVALTGCILMLVFLKYGRS----------------- 434

  Fly   626 QPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRS 690
                                    ||...|.|.....:||.:.|...       |:......|.|
Zfish   435 ------------------------SKFGMKGSSSVISNDDDSASPLH-------HVSNGNNTPSS 468

  Fly   691 GLSELIQIGRGEFGD--VFVGKLKATLVTSP-------SDKDADTEKQHSNSEN-------GSGG 739
                      .|.|.  |.:|..|..::.:|       |...:||..||....|       |.|.
Zfish   469 ----------SEMGPDAVIIGMTKIPVIENPQYFRNPGSMLKSDTLVQHIKRHNILLKRELGEGA 523

  Fly   740 SGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQL 804
            .|               |..:.:...:..:::        :.||.||.| |...|....:|.|:.
Zfish   524 FG---------------KVFLAECYNLSPDQE--------KILVAVKTL-KEASESGRADFHREA 564

  Fly   805 DLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATA-GKVNTATAGSSSPPPLTTSQ 868
            :||..:.|:.:|:.:|:|.|.||..||.||...|||.:||.|.. ..|..|....|....||..|
Zfish   565 ELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQQSLLVELTQPQ 629

  Fly   869 VLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPI 932
            :|.:|.|||.||..:....|.|||||||||::....:||:....:.:|.||.:|:: ..:|:|||
Zfish   630 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 694

  Fly   933 RWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPD 997
            ||:.||.|....:||:||:::.|||:||:|... |.|..:|:|.:|::....|.: .......|.
Zfish   695 RWMPPESIMYRRFTTESDVWSLGVVLWEIFTYG-KQPWYQLSNNEVIECITQGRV-LQRPRTCPK 757

  Fly   998 SLREILLSCWVSNPKERPSFSQ---LGAALSKA 1027
            .:.:::|.||...|..|.:..:   |..:|:||
Zfish   758 EVYDLMLGCWQREPYMRLNIKEIHNLLQSLAKA 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352
Ig 31..115 CDD:299845
IGc2 133..195 CDD:197706
Ig 268..373 CDD:299845 17/106 (16%)
Ig 395..460 CDD:143165 20/69 (29%)
I-set 468..559 CDD:254352 21/97 (22%)
IGc2 484..549 CDD:197706 14/68 (21%)
PTK_CCK4 686..1026 CDD:133178 108/360 (30%)
STYKc 692..1020 CDD:214568 104/348 (30%)
ntrk2bNP_001184090.2 leucine-rich repeat 62..86 CDD:275378
LRR_8 85..144 CDD:290566 1/7 (14%)
leucine-rich repeat 87..110 CDD:275378
leucine-rich repeat 111..133 CDD:275378
IG_like 194..279 CDD:214653 27/87 (31%)
Ig 205..275 CDD:143165 22/72 (31%)
Ig_TrkB_d5 297..375 CDD:143263 17/79 (22%)
PTKc_TrkB 507..796 CDD:270675 98/310 (32%)
Pkinase_Tyr 513..784 CDD:285015 92/296 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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