DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and ror2

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_021327888.1	Gene:	ror2 / 561183	ZFINID:	ZDB-GENE-060427-5	Length:	939	Species:	Danio rerio

Alignment Length:	772	Identity:	176/772 - (22%)
Similarity:	311/772 - (40%)	Gaps:	135/772 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 TLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIE--QLKFVPQPTSKNLELDAVVAKVHCK 400
            |.::|.   :|...::.: ::||.|...|  |.|...|  .|:|:.||.:..: :....|.:|||
Zfish    27 TFAYAE---ADVNLFESE-EIEALAEAQS--GGLPTPEGYYLEFLEQPNNITI-VQGQTATLHCK 84

  Fly   401 AQGTPTPQVQWVR-DGENTTLPDHVEV---DANGTLIFRNVNSEHRGNYTCLATNSQGQINATVA 461
            ..|.|.|.::|:: |.........|.:   :|...|..:::::...|.|.|:||||...|:||..
Zfish    85 VAGHPRPSIRWLKNDAPVVQEQGRVSIRKTEAGSKLRIQDLDTTDTGYYQCVATNSIKVISATGV 149

  Fly   462 INVVVTPKFSVPPVGPIE-TSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENG 525
            :.|.:......|..|..: |.|:|    .||    |...|..                .||:.|.
Zfish   150 LYVRLGNTGQSPAHGAEDSTHEKG----FCQ----PYRGIAC----------------ARFIGNR 190

  Fly   526 TLEIRNVQVEDEGSYGCT-----IGNSAGLKREDVQLVVKTTGDGFAPE-ESGGDG--------- 575
            ::.:.::|::.|.....|     ||.|..|..:..:..:.:......|. |.|..|
Zfish   191 SIYVESLQMQGESENRITAAFTMIGTSTQLSDQCSEFAIPSFCYYVFPLCEEGTRGPRRRQLCRD 255

  Fly   576 -------------FLVTRA-VLITMTVALAYIVLV-------------VGLMLWCRYRRQARKAR 613
                         :.:.|: .||.|.:.|....|:             :||        ..:.:.
Zfish   256 ECEALENDLCNAEYTIARSNPLILMQLELPVCSLLPHPGSPDASSCIRIGL--------PPQYSP 312

  Fly   614 LNDLSTKEAGGD-QPDVAGNGKGSEQEPCLSKQHNGHSKSR------------SKSSGDAQKS-- 663
            .:.....|:||: :..|:....|.:.:|..::..:.|..|.            .::.|...:|
Zfish   313 PDHSCYNESGGNYKGTVSVTKSGFQCQPWSAQYPHSHHLSPIEYPQLRGGHNFCRNPGGQMESPW 377

  Fly   664 -------------DDTACSQQSRASKKSAHI-YEQLALPR--SGLSELIQIGRGEFGDVFVGKLK 712
                         |...|:...:..|:..:| ...:|.|.  :.|..||.:.|.:..:......:
Zfish   378 CFTLDPNVRVDLCDIPPCNPPEKMKKELLYILIPSVATPLVFACLFFLICMCRNKQKESVDTPTR 442

  Fly   713 ATLVTSPS-DKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQ 776
            ..|..||| :.:.....||.:.......:.|....:..|.|.|..|.....:......||
Zfish   443 RQLTASPSQEMELPLLNQHKHQAKLRELNLSAVRFMEELGEDRFGKVYKGHLYGTAPGEQ----- 502

  Fly   777 SGLEQLVLVKALNKVKDEQAC-QEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDL 840
               .|:|.:|.: |.|||... :|||.:..|...:.|..:|.|.|:..::.|..|:..|:..|||
Zfish   503 ---TQVVAIKTV-KDKDEGPLREEFRHEAMLRSRLQHPNIVCLLGVITKEQPMSMIFSYSGQGDL 563

  Fly   841 KQFLLATAGKVNTATAGSSSPPPLTTSQV--LAVAYQIARGMDAIYRARFTHRDLATRNCVISSE 903
            .:||:..:...:..::........|..|.  |.:..|:|.||:.:......|:|||.||.::..:
Zfish   564 HEFLVMRSPHSDVGSSDDDKTVKSTLEQADFLHIVTQVAAGMEYLSSHHVVHKDLAARNILVCDK 628

  Fly   904 FIVKVSYPALCKDKYSREYHKHRN-TLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATK 967
            ..||:....|.::.||.:|:|... :..||||::||.|...:::|.|||::||||:||:|:...:
Zfish   629 LNVKILDLGLFREVYSADYYKLMGASPFPIRWMSPEAILYGKFSTDSDIWSYGVVLWEIFSYGLQ 693

  Fly   968 LPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAAL 1024
             |:...:|:.|::..:...: .|..:..|..:..::|.||...|..||.|..:.|.|
Zfish   694 -PYCGYSNQDVIEMVRNRQV-LSCPDDCPAWIYTMMLECWNEFPSRRPRFKDIHARL 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	9/34 (26%)
		Ig	395..460	CDD:143165	21/68 (31%)
		I-set	468..559	CDD:254352	19/96 (20%)
		IGc2	484..549	CDD:197706	14/69 (20%)
		PTK_CCK4	686..1026	CDD:133178	94/346 (27%)
		STYKc	692..1020	CDD:214568	90/332 (27%)
ror2	XP_021327888.1	I-set	63..152	CDD:254352	25/89 (28%)
		CRD_FZ	171..307	CDD:321937	28/167 (17%)
		KR	314..395	CDD:238056	11/80 (14%)
		PTKc_Ror2	468..751	CDD:270673	82/292 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900