Protein Alignment otk and Nptn

DIOPT Version :10

• Sequence 1: NP_523705.2
• Gene: otk / 36283
• FlyBaseID: FBgn0004839
• Length: 1033
• Species: Drosophila melanogaster
• Sequence 2: NP_001400276.1
• Gene: Nptn / 56064
• RGDID: 620296
• Length: 397
• Species: Rattus norvegicus
• Alignment Length: 466
• Identity: 101/466 - (21%)
• Similarity: 171/466 - (36%)
• Gaps: 143/466 - (30%)

  Fly   240 GAAGLEAL---------PAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRW-- 293
            ||..|..|         |.|.::...|:.|:.::.: .|:...|.|     |.:.:...:::|
  Rat     8 GALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKL-TGDAFELYC-----DVVGSPTPEIQWWY 66

  Fly   294 ---------RK--DGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIAS 347
                     |:  ||...|:|.:       ..::.|...::|| ..||.|              .
  Rat    67 AEVNRAESFRQLWDGARKRRVTV-------NTAYGSNGVSVLR-ITRLTL--------------E 109

  Fly   348 DAGQYQCQLQLE-AHAPINSSPGI--------LEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQG 403
            |:|.|:|:...: ....:..:|.|        :.|:::.:.|   ||:.:.:...:..|..:...
  Rat   110 DSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIV---TSEEVIIRDSLLPVTLQCNL 171

  Fly   404 TPTPQV----QWVRDGENTTLPDHVEVDA---NGTLIFRNVN---SEHRGNYTCL-ATNSQGQIN 457
            |.:...    .|.::|        ||:.|   |.:.:...:|   :|..|.|.|: ...|..:.|
  Rat   172 TSSSHTLMYSYWTKNG--------VELTATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKAN 228

  Fly   458 ATVAINVVVTPKFSVPPVGPIETSEQGT----VVMHCQAIGDPKPTIQWDKDLKYLSENNTDRE- 517
            ||:.:.       :.|.:...:.||...    .:|:|:::|.|.|...|.|     .||....|
  Rat   229 ATIEVK-------AAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWMWRK-----KENGVFEEI 281

  Fly   518 -----RFRFL--ENGT-LEIRNVQV-EDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGG 573
                 ||..:  ||.| |.|.|:|: ||.|.|.|...||.|.......|.|::......|
  Rat   282 SNSSGRFFIINKENYTELNIVNLQITEDPGEYECNATNSIGSASVSTVLRVRSHLAPLWP----- 341

  Fly   574 DGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQ 638
              ||...|.:|.:.|     ::||       |.::.|...:.|       .|:|  ||
  Rat   342 --FLGILAEIIILVV-----IIVV-------YEKRKRPDEVPD-------DDEP--AG------- 376

  Fly   639 EPCLSKQHNGH 649
             |..:...|.|
  Rat   377 -PMKTNSTNNH 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	Ig_3	31..99	CDD:464046
		Ig strand B	133..137	CDD:409353
		Ig	<135..197	CDD:472250
		Ig strand C	150..154	CDD:409353
		Ig strand E	171..175	CDD:409353
		Ig strand F	185..190	CDD:409353
		Ig	265..360	CDD:472250	20/108 (19%)
		Ig strand B	272..276	CDD:409571	1/3 (33%)
		Ig strand C	290..294	CDD:409571	1/14 (7%)
		Ig strand E	337..341	CDD:409571	0/3 (0%)
		Ig strand F	351..356	CDD:409571	2/4 (50%)
		Ig	395..460	CDD:409353	16/75 (21%)
		Ig strand B	395..399	CDD:409353	1/3 (33%)
		Ig strand C	408..412	CDD:409353	0/7 (0%)
		Ig strand E	430..434	CDD:409353	0/3 (0%)
		Ig strand F	444..449	CDD:409353	2/5 (40%)
		Ig strand G	457..460	CDD:409353	2/2 (100%)
		I-set	468..559	CDD:400151	31/104 (30%)
		Ig strand B	486..490	CDD:409570	1/3 (33%)
		Ig strand C	499..503	CDD:409570	0/3 (0%)
		Ig strand E	525..529	CDD:409570	2/4 (50%)
		Ig strand F	539..544	CDD:409570	2/4 (50%)
		Ig strand G	552..555	CDD:409570	0/2 (0%)
		PTK_CCK4	686..1026	CDD:133178
Nptn	NP_001400276.1	Ig	31..146	CDD:472250	25/142 (18%)
		Ig strand B	48..52	CDD:409353	1/3 (33%)
		Ig strand C	61..65	CDD:409353	0/3 (0%)
		Ig strand E	99..103	CDD:409353	2/4 (50%)
		Ig strand F	113..118	CDD:409353	2/4 (50%)
		Ig strand G	137..140	CDD:409353	0/2 (0%)
		Narpin, mediates binding with FGFR1 and has antidepressant-like activity	149..161		3/14 (21%)
		Ig	167..218	CDD:472250	11/58 (19%)
		Ig strand C	179..184	CDD:409353	0/4 (0%)
		Ig strand E	200..204	CDD:409353	0/3 (0%)
		Ig strand F	214..218	CDD:409353	1/3 (33%)
		Ig	249..332	CDD:472250	28/87 (32%)
		Ig strand B	254..258	CDD:409353	1/3 (33%)
		Ig strand C	267..271	CDD:409353	0/3 (0%)
		Ig strand E	298..302	CDD:409353	1/3 (33%)
		Ig strand F	312..317	CDD:409353	2/4 (50%)
		Ig strand G	325..328	CDD:409353	0/2 (0%)