DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and hmcn1

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:XP_005160777.1 Gene:hmcn1 / 559150 ZFINID:ZDB-GENE-041014-322 Length:5623 Species:Danio rerio


Alignment Length:982 Identity:217/982 - (22%)
Similarity:332/982 - (33%) Gaps:308/982 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 PQSQSVVENESVKFEC-------ESTDSYSELHYDWLHNGHRIAYDK---RVHQIGSNLHIEAVR 85
            |..:|||.:.|:..:|       .||        .||.:|..:...:   ::...|..|||:.. 
Zfish  1826 PAERSVVLHTSISLQCVVSGIPPPST--------TWLKDGRPVDTTQEFLKLESAGRVLHIKKA- 1881

  Fly    86 RTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELL-------LKCHVEGAS 143
            |.||.|.|.|:|||.|.   ||....:|||  .|..|:|..|...||.:       |||...|: 
Zfish  1882 RLEDAGKYTCVATNAAG---EAQQHIRLSV--HEPPSIQYAGEMLNETILAGFQIQLKCKATGS- 1940

  Fly   144 GDLEPL-EIEWYRNSEKLSTWKNVQL--DQHRLIIRQPGSEDDGLYRCTASNAAG---------- 195
                || .:.||::...|::...|.:  ..|.|.|.:....|.|.|:|.|.|.||          
Zfish  1941 ----PLPAVTWYKDGRPLTSAAGVNILSRGHVLEIDRAQVSDAGFYKCVAINVAGSTELTYSLQV 2001

  Fly   196 ----RVMSKQGYV-----------YQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKR------- 238
                .:.||.|.|           .::|...:|.|...|....:.|:.....:..|.|       
Zfish  2002 YVPPTISSKGGMVTVVVNDPVRLECEASGVPVPSLTWLKEGSPVSSFSDGIQVLSGGRVLSFISA 2066

  Fly   239 ----GGAAGLEALPAAPE-----DLRIVQGP--IGQSI---IKEGEPTALTCLYE-LPDELKNQR 288
                .|.....|:.|..|     :||:...|  :|:.:   :..|:...|.|..: :|..     
Zfish  2067 QVSDAGHYTCVAVNAGGEQHREYELRVYVPPNIMGEEVNNTVLMGQSVQLHCQSDAIPPP----- 2126

  Fly   289 IQLRWRKDGK-LLRQVEL----------------------------------------------- 305
             .|.|||||: |.|:..|                                               
Zfish  2127 -ALSWRKDGRPLYRKPGLSVSEDGSFLKIISAQVQDTGRYTCEATNVAGKTEKHYNLNVWVPPSI 2190

  Fly   306 -------------GG-------SAPIPGHSFDSGKD-ALLREDARLVLHKQNGTLSFASIIASDA 349
                         ||       |:.||..|....|| :.|:.|:|:.:......|..:|...:||
Zfish  2191 RGSDEVSSLTVIEGGLITLVCESSGIPPPSLIWKKDGSELKGDSRVRVLSGGRQLQISSAEKADA 2255

  Fly   350 GQYQC-------------QLQLEAHAPINSSPGILEVIE---------QLKFVPQP--------- 383
            ..|.|             .||:.....|:||....|.:.         :...||:|         
Zfish  2256 SSYTCLASSAAGSAIKEYNLQVYVRPSISSSAQDEETVTRGGDITLRCEADGVPRPAVSWMKDGR 2320

  Fly   384 ---TSKNLE----------LDAVVA----------------------KVH--------------- 398
               |.:..:          |:|.||                      .||               
Zfish  2321 PLSTGRKAQILNEGRLLRILEAQVADTGRYTCIAINVAGQADRKYDVNVHVPPTIIGQTHMPENI 2385

  Fly   399 -----------CKAQGTPTPQVQWVRDGENTTLPDHVEVDANGT-LIFRNVNSEHRGNYTCLATN 451
                       |:|.|.|.|.:.|::||:..:....|.|.:.|. |...:..|...|.|||:.:|
Zfish  2386 SVVVKNPVVLTCEASGMPPPAITWLKDGQPISTSSSVRVISGGRGLRLMHAASSDAGRYTCIVSN 2450

  Fly   452 SQGQINATVAINVVVTPKFSVPPVGPIE---TSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENN 513
            |.|:......:.|:|.|  |:...|.:|   ..|:...::.|:..|:|.|.|.|.||.:.|:.:.
Zfish  2451 SAGEERKNFDLYVLVPP--SIVNEGTVEDVKVKERQNAILACEVTGNPVPEITWLKDGQPLASDT 2513

  Fly   514 TDRERFRFLENGT-LEIRNVQVEDEGSYGCTIGNSAG--LKREDVQLVVKTTGDGFAPEESGGDG 575
                |.:.:.||. |:|...||.|.|.|.|...||||  .:..::.::|..|..|..||.|..:.
Zfish  2514 ----RLQVMSNGRFLQISASQVADTGRYSCLASNSAGDRSRHFNLNVLVSPTIAGSGPEGSAEEV 2574

  Fly   576 FLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKAR----------LNDLSTKEA-GGDQPDV 629
            .:...:....:..|.:|...::   .|.:.......:|          |..|:.||. .|....|
Zfish  2575 TVTLNSPTSLVCEAQSYPPAII---TWLKDGTPFESSRNVRVLPGGRTLQILNAKEEDAGRYTCV 2636

  Fly   630 AGNGKGSEQE---------PCLSKQH-NGHSKSRSKSSGDAQKSDDTACSQQS------------ 672
            |.|..|...:         |.::|.. .|.|.:..:.......:....|..|:            
Zfish  2637 ATNEAGETLKNYEVKVFVPPVINKNDIPGESLAPKEVKIKVNNTLTLECEAQAIPTPTLVWYKDG 2701

  Fly   673 RASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGS 737
            :..|...|    |.:..:|  .::||...:..|.......||.:....:||.|...|...|..|.
Zfish  2702 QILKADGH----LTITANG--RIVQIKHTQVSDTGRYTCVATNIAGEDEKDFDVNIQVPPSFRGF 2760

  Fly   738 GGSGSGS 744
            |.||.|:
Zfish  2761 GDSGPGN 2767

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352 28/93 (30%)
Ig 31..115 CDD:299845 28/93 (30%)
IGc2 133..195 CDD:197706 19/71 (27%)
Ig 268..373 CDD:299845 35/187 (19%)
Ig 395..460 CDD:143165 23/113 (20%)
I-set 468..559 CDD:254352 29/96 (30%)
IGc2 484..549 CDD:197706 22/65 (34%)
PTK_CCK4 686..1026 CDD:133178 16/59 (27%)
STYKc 692..1020 CDD:214568 15/53 (28%)
hmcn1XP_005160777.1 VWA_2 36..206 CDD:290253
IG_like 443..510 CDD:214653
I-set 514..600 CDD:254352
ig 522..596 CDD:278476
I-set 604..688 CDD:254352
Ig 618..689 CDD:299845
I-set 694..781 CDD:254352
IGc2 708..771 CDD:197706
I-set 785..876 CDD:254352
Ig 789..876 CDD:299845
IG 888..969 CDD:214652
IGc2 895..959 CDD:197706
I-set 973..1060 CDD:254352
Ig 990..1059 CDD:299845
IG 1084..1162 CDD:214652
Ig 1092..1159 CDD:143165
I-set 1166..1251 CDD:254352
IGc2 1179..1241 CDD:197706
I-set 1251..1348 CDD:254352
Ig 1254..1348 CDD:299845
I-set 1360..1441 CDD:254352
IGc2 1367..1431 CDD:197706
I-set 1450..1535 CDD:254352
IGc2 1461..1525 CDD:197706
IG_like 1547..1628 CDD:214653
Ig 1558..1625 CDD:143165
I-set 1641..1722 CDD:254352
Ig 1641..1718 CDD:299845
Ig 1725..1817 CDD:299845
IG 1738..1815 CDD:214652
Ig 1818..1908 CDD:299845 28/93 (30%)
IG 1826..1908 CDD:214652 28/93 (30%)
IG 1922..2001 CDD:214652 23/83 (28%)
Ig 1927..2001 CDD:299845 21/78 (27%)
IG 2014..2093 CDD:214652 13/78 (17%)
IGc2 2019..2083 CDD:197706 10/63 (16%)
Ig 2096..2186 CDD:299845 15/95 (16%)
IG_like 2107..2184 CDD:214653 13/82 (16%)
Ig 2187..2280 CDD:299845 19/92 (21%)
I-set 2197..2277 CDD:254352 18/79 (23%)
Ig 2292..2371 CDD:299845 9/78 (12%)
IG 2292..2369 CDD:214652 8/76 (11%)
I-set 2373..2463 CDD:254352 20/89 (22%)
IGc2 2391..2453 CDD:197706 19/61 (31%)
IG 2476..2556 CDD:214652 26/83 (31%)
IGc2 2484..2546 CDD:197706 22/65 (34%)
IG 2572..2652 CDD:214652 13/82 (16%)
IGc2 2583..2642 CDD:197706 12/61 (20%)
I-set 2670..2751 CDD:254352 14/86 (16%)
IGc2 2678..2741 CDD:197706 11/68 (16%)
IG 2774..2850 CDD:214652
IGc2 2777..2840 CDD:197706
I-set 2864..2945 CDD:254352
Ig 2864..2938 CDD:299845
Ig 2949..3039 CDD:299845
IG_like 2957..3037 CDD:214653
I-set 3051..3132 CDD:254352
IGc2 3059..3122 CDD:197706
I-set 3154..3226 CDD:254352
Ig 3154..3223 CDD:143165
Ig 3229..3323 CDD:299845
I-set 3238..3321 CDD:254352
IG 3335..3415 CDD:214652
Ig 3343..3415 CDD:299845
Ig 3418..3508 CDD:299845
IG 3428..3508 CDD:214652
IG 3520..3601 CDD:214652
Ig <3533..3603 CDD:299845
I-set 3614..3694 CDD:254352
IGc2 3620..3684 CDD:197706
Ig 3697..3787 CDD:299845
IG_like 3704..3785 CDD:214653
Ig 3788..3878 CDD:299845
I-set 3789..3878 CDD:254352
IG_like 3891..3969 CDD:214653
Ig 3899..3968 CDD:299845
IG_like 3979..4060 CDD:214653
Ig 3990..4052 CDD:299845
I-set 4064..4150 CDD:254352
IGc2 4080..4140 CDD:197706
Ig 4161..4241 CDD:299845
IG_like 4161..4241 CDD:214653
I-set 4245..4324 CDD:254352
IGc2 4260..4320 CDD:197706
Ig 4352..4420 CDD:299845
I-set 4425..4511 CDD:254352
Ig 4439..4512 CDD:299845
TSP1 4518..4569 CDD:214559
TSP1 4583..4626 CDD:214559
TSP1 4631..4683 CDD:214559
TSP1 4688..4740 CDD:214559
TSP1 4745..4797 CDD:214559
TSP1 4802..4854 CDD:214559
nidG2 4855..5070 CDD:238158
EGF_CA 5091..5130 CDD:214542
EGF_CA 5131..5174 CDD:284955
EGF_CA 5176..5213 CDD:214542
EGF_CA 5214..5251 CDD:214542
EGF_CA 5256..5297 CDD:284955
EGF_CA 5299..5338 CDD:214542
EGF_CA 5420..5459 CDD:214542
EGF_CA 5460..5496 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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