DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otk and il1rapl1b

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001136054.1	Gene:	il1rapl1b / 557801	ZFINID:	ZDB-GENE-090109-2	Length:	700	Species:	Danio rerio

Alignment Length:	402	Identity:	87/402 - (21%)
Similarity:	143/402 - (35%)	Gaps:	85/402 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 GEPTALTCL---------YELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALL 324
            |||..:.|.         |   ...::..:.|.|.:........|     ||   :.| |...|.
Zfish    46 GEPVRIKCALFYGYIRANY---THAQSAGLSLMWYRSATHTDHEE-----PI---TLD-GTRTLK 98

  Fly   325 REDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAH--------APINSSPGILEVIEQLKFVP 381
            .|||          |.|......|:|.|.|.|:..::        ....:|.|:....:..:...
Zfish    99 EEDA----------LWFRPAQLQDSGHYSCVLRNSSYCMKVSMALTVAENSSGLCYNSKMRRLEK 153

  Fly   382 QPTSKNLELDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRGNYT 446
            ...||:  .|.:...:.........|.|.|.::.........: :.....|..|:|..:..||||
Zfish   154 AELSKS--KDILCPDIQDYTPAGSEPHVTWYKECRPKQWRSSI-IRTADLLSIRDVREDDIGNYT 215

  Fly   447 CLATNSQGQINATVAINVVV-----TPKFSVPP---VGPIETSEQGTVVMHCQAI----GDPKPT 499
            |.....:..:..|..:.|..     .||...||   :..:|....|.|.:.|:|.    ||..|.
Zfish   216 CEIQFGRFLVRRTTELTVTAPLTDKPPKILQPPEHKLSVMELQLGGPVNLTCRAFFGYSGDVSPL 280

  Fly   500 IQWDKDLKYLSENNTDRERFRFLE-------------NGTLEIRNVQVEDEGSYGCTIGNSAGLK 551
            |.|.|..|::.:  .|..|.|..|             :.:|.|.::|.||.|:|.|.:.|..|.:
Zfish   281 IYWMKGEKFIED--LDETRIRESEIKMVREHLGEQEVSVSLTIDSLQEEDLGNYSCYVENGHGRR 343

  Fly   552 REDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLND 616
            ...:||..:..  .:..|.:||.|.::   :::...|:| |....:.|||:.|          |.
Zfish   344 HAIIQLSRREL--MYTVELAGGLGAIL---LMLIFLVSL-YKCYRIELMLFYR----------NH 392

  Fly   617 LSTKEAGGDQPD 628
            ..:::..|:..|
Zfish   393 FGSEDVDGENKD 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	25/120 (21%)
		Ig	395..460	CDD:143165	11/64 (17%)
		I-set	468..559	CDD:254352	32/110 (29%)
		IGc2	484..549	CDD:197706	24/81 (30%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
il1rapl1b	NP_001136054.1	PHA02785	7..334	CDD:165149	68/314 (22%)
		Ig	32..135	CDD:299845	23/110 (21%)
		Ig	148..234	CDD:299845	15/88 (17%)
		Ig	263..348	CDD:143165	24/86 (28%)
		TIR	405..559	CDD:279864	87/402 (22%)
		Required for synaptic vesicle accumulation during synaptogenesis	564..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910