DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and cd22

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001077292.1	Gene:	cd22 / 554810	ZFINID:	ZDB-GENE-050522-521	Length:	417	Species:	Danio rerio

Alignment Length:	391	Identity:	93/391 - (23%)
Similarity:	152/391 - (38%)	Gaps:	70/391 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 LPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPI 311
            |.||.....:...|.|..:. ||.....:||::.||.||  ....:|.:.||  .|.:.|....|
Zfish    12 LSAAVASWSVSYDPKGMCVF-EGSSVDFSCLFDYPDYLK--LTVTKWFRPGK--NQKQDGSQQGI 71

  Fly   312 PGHSFD--------SGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQL-EAHAPINSS 367
            ..|..:        .|:.|...::       :|.:|...::...|.|:|..:::. :.:.....|
Zfish    72 TVHHSNIALISWPYKGRTAYANQN-------KNCSLRLRNVSKRDIGRYFFRIETNDYYEKFTGS 129

  Fly   368 PGILEVIEQLKFVPQP------TSKNLEL----DAVVAKVHCKAQG-TPTPQ-VQWVRDGENTTL 420
            .||     |||....|      |.|..|.    |:|.  :.|.|:. |||.: ..|.::  :..|
Zfish   130 GGI-----QLKVAVLPLRVIVKTQKASEQIDEGDSVT--LTCSAENCTPTEESFLWFKN--HLLL 185

  Fly   421 PDHVEVDANGT-LIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQG 484
            |     .|.|. |...:|:....|||:|...|:...::|...::|...||.....|...|..::|
Zfish   186 P-----QATGNELRISSVSHSDAGNYSCGLKNTNTTLSAQTLLDVRYQPKDVEISVSSSEEIQEG 245

  Fly   485 T-VVMHCQAIGDPKPT-IQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNS 547
            . :.:.|::..:|..| ..|.|        .||...........|.||:..::|.|.|.||..|.
Zfish   246 NPLTLTCKSKANPAVTHYSWFK--------ITDANMSSVGSGSELTIRSASLQDAGLYFCTATNH 302

  Fly   548 AGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAV--LITMTVALAYIVLVVGLMLWCRYRRQAR 610
            .|.::..|: .:|...|..         ||::.:.  |..|.:.|...||.|...|:...::.|.
Zfish   303 IGTQKSTVK-ALKVASDRH---------FLLSASAVFLFVMAMLLVLFVLFVRKKLFTSQKQTAE 357

  Fly   611 K 611
            :
Zfish   358 Q 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	25/113 (22%)
		Ig	395..460	CDD:143165	18/67 (27%)
		I-set	468..559	CDD:254352	23/92 (25%)
		IGc2	484..549	CDD:197706	17/66 (26%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
cd22	NP_001077292.1	Ig	19..122	CDD:299845	24/114 (21%)
		IG_like	25..136	CDD:214653	29/127 (23%)
		IG_like	156..225	CDD:214653	20/77 (26%)
		IGc2	156..208	CDD:197706	17/60 (28%)
		IG_like	237..315	CDD:214653	20/86 (23%)
		IGc2	244..304	CDD:197706	17/67 (25%)
		MSC	<307..386	CDD:286487	13/62 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900