DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and Hmcn1

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:XP_006529820.1 Gene:Hmcn1 / 545370 MGIID:2685047 Length:5658 Species:Mus musculus


Alignment Length:1216 Identity:256/1216 - (21%)
Similarity:414/1216 - (34%) Gaps:409/1216 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ISICGLVMALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDK 70
            :::.|||..|:..|           |...||:|.:.:...|............|:.|...:..:.
Mouse   882 VTVTGLVAPLIGIS-----------PSMASVIEGQPLTLPCTLLAGNPIPERRWMKNSAMLVQNP 935

  Fly    71 --RVHQIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNEL 133
              .|...|| ||||.| |.:|.|.|.|:|:|:|....:.:           |.:|.:|.|.::..
Mouse   936 YITVRSDGS-LHIERV-RLQDGGKYTCVASNVAGTNNKTT-----------SVAVHVLPSIQHGQ 987

  Fly   134 LLKCHVEG--------ASGDLEPLEIEWYRNSEKLSTWKNVQLD---QHRLIIRQPGSEDDGLYR 187
            .:...:||        |||..:| .|.|.:..|.:|| .:.:..   ...|.:..||||:.|.|.
Mouse   988 QILSTIEGVPVTLPCRASGIPKP-SITWSKKGELIST-SSAKFSAGADGSLYVVSPGSEESGEYI 1050

  Fly   188 CTASNAAG--------------RVMSKQGYVYQS-----------------SVKCLPR--LPRRK 219
            |||:||||              ||...|..:.|.                 ..|.||.  :...|
Mouse  1051 CTATNAAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEAILPCEAKSLPPPIITWAK 1115

  Fly   220 NEKMMESWD-KQTFLCRGK------RGGAAGL--------------------EALPAAPEDLRIV 257
            :.:::..:. :.|||..|.      |...:|:                    ...|......|.:
Mouse  1116 DSQLISPFSPRHTFLPSGSMKITETRVSDSGMYLCVATNIAGNVTQSVKLSVHVPPKIQHGNRHI 1180

  Fly   258 QGPIGQSI----------------IKEGEP-------------------------TALTC----- 276
            :..:||.:                .|.|.|                         ...||     
Mouse  1181 KVQVGQRVDILCNAHGSPPPVITWFKSGRPFLDGAQHPGSPDGTLSIEQAVISDAGVYTCAATNI 1245

  Fly   277 -----------LYELP--------------DELKNQRIQ------------LRWRKDGKLLRQVE 304
                       :.|.|              :.|.||||:            ::|..:|:     |
Mouse  1246 AGSDEAEVTLHVQEPPSVEDLQPPFNTPFQERLANQRIEFPCPAKGTPKPTIKWLHNGR-----E 1305

  Fly   305 LGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPG 369
            :.|..  ||.|       :|.:.|.||:         ||:...:.|:|.|....||        |
Mouse  1306 VTGQE--PGVS-------ILEDGALLVI---------ASVTPHNNGEYICVAVNEA--------G 1344

  Fly   370 ILEVIEQLKFVPQPTSKNLE-------LDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVD 427
            ..|....||....|..::.|       |.:.:|.::|:.:|||:|.:.|.:|....|....|::.
Mouse  1345 TTERKYNLKVHVPPVIRDKEHVTNVSVLTSQLASLYCEVEGTPSPVITWYKDDIQVTESSTVQIV 1409

  Fly   428 ANGTL--IFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMH- 489
            .||.:  :|: |::|..|.|:|.|.|..|......::||:|.|..    :|....||...|:.| 
Mouse  1410 NNGKILKLFK-VSAEDAGRYSCKAINIAGTSQKDFSVNVLVPPSI----LGASSPSEVSVVLNHN 1469

  Fly   490 ----CQAIGDPKPTIQWDKDLK--YLSENN---TDRERFRFLENGTLEIRNVQVEDEGSYGCTIG 545
                |...|.|.|.|.|.||.|  :|.:.|   :||.:       :|.:||.:..|:|.|.||:.
Mouse  1470 VTLQCPGTGVPFPAIHWFKDGKPLFLGDPNIELSDRGQ-------SLHLRNARRSDKGRYQCTVS 1527

  Fly   546 NSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQAR 610
            |:||.:.:|::|.|      :.|....|.......:.|:...|.|.           |..|    
Mouse  1528 NAAGKQAKDIKLTV------YVPPSIKGGNITTEISALLNSIVKLE-----------CETR---- 1571

  Fly   611 KARLNDLSTKEAGGDQPDVAGNGKG-----SEQEPCLSKQHNGHSKSRSKSSGDAQKSDDT--AC 668
                        |...|.:.....|     |.|...:.|....|.:.       ||.||..  .|
Mouse  1572 ------------GLPVPAITWYKDGQVVTSSSQALYIDKGQLLHIQR-------AQVSDSATYTC 1617

  Fly   669 SQQSRA--SKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHS 731
            ...:.|  ::||.|:                       |::|.......:|:||:|....     
Mouse  1618 HAANVAGTAEKSFHV-----------------------DIYVPPTIEGDLTAPSNKQVII----- 1654

  Fly   732 NSENGSG------GSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNK 790
                |..      .:|:....|:.|.:....|.| |:|          |.::|.::|.::.||..
Mouse  1655 ----GQSLILECKAAGNPPPILTWLKDGVPVKAS-DNI----------HIEAGGKKLEILSALEV 1704

  Fly   791 VKDEQAC--------QEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLAT 847
            .:.:..|        :|.:.::|:|...:.:|        .|:..:::||...        ||..
Mouse  1705 DRGQYICVATSVAGEREIKYEVDVLVPPAVEG--------GEETSYFIVLANN--------LLEL 1753

  Fly   848 AGKVNTATAGSSSPPP----LTTSQVL--AVAYQIARGMDAIYRARFTHRDLATRNCVISS---- 902
            ..:|      |.||||    |...|::  ...::|......:..|:....|.....||.::    
Mouse  1754 DCQV------SGSPPPTIMWLKGGQLIDERDGFKILLNGRKLVIAQAQVSDTGLYQCVATNIAGD 1812

  Fly   903 ---EFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGV----VVWE 960
               ||.|.|..|...|.....|     .|::..:.:..:||            |.|:    :.|.
Mouse  1813 HRKEFEVTVHVPPTIKSSDLPE-----KTVVRYKPVTLQCI------------ANGIPNPSITWL 1860

  Fly   961 LFNQATKLPH---EELTNEQVVQRSQAGSLEWSVAEATPDSLREIL 1003
            ..:|.....|   ::|..:...:|.......|..|.|:..|...:|
Mouse  1861 KDDQPVNTAHGNLKDLDADSGPRRRGKEDRRWHTAVASIQSSGRVL 1906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352 23/90 (26%)
Ig 31..115 CDD:299845 23/85 (27%)
IGc2 133..195 CDD:197706 23/72 (32%)
Ig 268..373 CDD:299845 30/171 (18%)
Ig 395..460 CDD:143165 21/66 (32%)
I-set 468..559 CDD:254352 32/100 (32%)
IGc2 484..549 CDD:197706 24/74 (32%)
PTK_CCK4 686..1026 CDD:133178 64/352 (18%)
STYKc 692..1020 CDD:214568 64/346 (18%)
Hmcn1XP_006529820.1 vWFA 42..198 CDD:238119
Ig 520..608 CDD:386229
Ig 612..696 CDD:386229
I-set 702..789 CDD:369462
I-set 793..884 CDD:369462 0/1 (0%)
Ig 890..977 CDD:386229 26/110 (24%)
Ig 980..1071 CDD:386229 27/92 (29%)
I-set 1085..1167 CDD:369462 10/81 (12%)
I-set 1171..1257 CDD:369462 9/85 (11%)
Ig 1266..1354 CDD:386229 26/118 (22%)
I-set 1368..1447 CDD:369462 22/79 (28%)
IG_like 1459..1541 CDD:214653 30/88 (34%)
Ig 1564..1632 CDD:386229 19/101 (19%)
I-set 1644..1728 CDD:369462 19/103 (18%)
I-set 1751..1821 CDD:369462 17/75 (23%)
Ig 1843..1935 CDD:319273 14/76 (18%)
Ig 1949..2031 CDD:386229
Ig 2044..2115 CDD:386229
I-set 2134..2214 CDD:369462
I-set 2226..2309 CDD:369462
Ig_3 2313..2390 CDD:372822
Ig 2429..2491 CDD:319273
I-set 2501..2590 CDD:369462
I-set 2605..2686 CDD:369462
I-set 2704..2785 CDD:369462
Ig 2818..2881 CDD:319273
I-set 2902..2983 CDD:369462
I-set 3005..3075 CDD:369462
I-set 3087..3170 CDD:369462
Ig 3192..3260 CDD:319273
Ig 3267..3361 CDD:386229
I-set 3377..3453 CDD:369462
I-set 3468..3546 CDD:369462
IG_like 3558..3639 CDD:214653
I-set 3652..3732 CDD:369462
I-set 3736..3823 CDD:369462
Ig 3846..3912 CDD:319273
Ig 3937..4004 CDD:319273
Ig 4028..4090 CDD:319273
I-set 4102..4188 CDD:369462
Ig 4209..4276 CDD:319273
I-set 4283..4368 CDD:369462
Ig 4387..4458 CDD:386229
I-set 4463..4549 CDD:369462
TSP1 4556..4607 CDD:214559
TSP1 4612..4664 CDD:214559
TSP1 4669..4721 CDD:214559
TSP1 4726..4778 CDD:214559
TSP1 4783..4835 CDD:214559
TSP1 4840..4892 CDD:214559
G2F 4891..5115 CDD:214774
EGF_CA 5130..5169 CDD:214542
EGF_CA 5170..5213 CDD:311536
EGF_CA 5215..5252 CDD:214542
EGF_CA 5253..5286 CDD:238011
EGF_CA 5295..5336 CDD:311536
EGF_CA 5338..5377 CDD:214542
EGF_CA 5455..5494 CDD:214542
EGF_CA 5495..5531 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 61 1.000 Domainoid score I10428
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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