DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment otk and ROR2

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_004551.2 Gene:ROR2 / 4920 HGNCID:10257 Length:943 Species:Homo sapiens


Alignment Length:781 Identity:177/781 - (22%)
Similarity:295/781 - (37%) Gaps:199/781 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   363 PINSSPGILEVIEQ--LKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVR-DGENTTLPDHV 424
            |::...|.:..::.  |.|: :|.:....:....|.:|||..|.|.|.|:|:: |......|..:
Human    46 PLDGQDGPIPTLKGYFLNFL-EPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRI 109

  Fly   425 ---EVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTV 486
               :.:....|..:::::...|.|.|:|||....|.||..:.|.:.|..|               
Human   110 IIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHS--------------- 159

  Fly   487 VMHCQAIGDPKPTIQWDKDLKYLSENNTDRER----FRFLENGTLEIRNVQVEDEGSYGCT---- 543
                     |....|.|    |..:......|    .||:.|.|:.:.::|::.|.....|    
Human   160 ---------PNHNFQDD----YHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFT 211

  Fly   544 -IGNSAGLKREDVQLVVKTTGDGFA---------------PEESGGDGFLVTRAVLITM--TVAL 590
             ||.|..|..:..|..:.:    |.               |.|...|...|..:.|...  |:|.
Human   212 MIGTSTHLSDQCSQFAIPS----FCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIAR 272

  Fly   591 AYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAG------------------NGKGSE 637
            :..::::.|.|          .:...|...|:    ||.|.                  ||.|.:
Human   273 SNPLILMRLQL----------PKCEALPMPES----PDAANCMRIGIPAERLGRYHQCYNGSGMD 323

  Fly   638 QEPCLSKQHNGHS---------KSRSKSSGD-------------------------------AQK 662
            .....|...:||.         .|...||.|                               .:.
Human   324 YRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMEL 388

  Fly   663 SDDTACSQQSRASKKSAHIY---EQLALPR--SGLSELIQIGRGEFGDVFVGKLKAT-------- 714
            .|..:||  .|.|.|...:|   ..:|:|.  :.|..|:.:.|        .|.||:        
Human   389 CDVPSCS--PRDSSKMGILYILVPSIAIPLVIACLFFLVCMCR--------NKQKASASTPQRRQ 443

  Fly   715 LVTSPS-DKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSG 778
            |:.||| |.:.....||..::                 .|..|.:::..:||:.|:...:..:..
Human   444 LMASPSQDMEMPLINQHKQAK-----------------LKEISLSAVRFMEELGEDRFGKVYKGH 491

  Fly   779 L--------EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYT 835
            |        .|.|.:|.|....:....:|||.:..|...:.|..||.|.|:..:..|..|:..|.
Human   492 LFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYC 556

  Fly   836 DWGDLKQFLL-----ATAGKV-NTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLA 894
            ..|||.:||:     :..|.. :..|..|:..||    ..:.:..|||.||:.:......|:|||
Human   557 SHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP----DFVHLVAQIAAGMEYLSSHHVVHKDLA 617

  Fly   895 TRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVV 958
            |||.::..:..||:|...|.::.|:.:|:| ..|:||||||:|||.|...:::..|||::||||:
Human   618 TRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVL 682

  Fly   959 WELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAA 1023
            ||:|:...: |:...:|:.||:..:...: ....:..|..:..:::.||...|..||.|..:.:.
Human   683 WEVFSYGLQ-PYCGYSNQDVVEMIRNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSR 745

  Fly  1024 L 1024
            |
Human   746 L 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352
Ig 31..115 CDD:299845
IGc2 133..195 CDD:197706
Ig 268..373 CDD:299845 2/9 (22%)
Ig 395..460 CDD:143165 20/68 (29%)
I-set 468..559 CDD:254352 19/99 (19%)
IGc2 484..549 CDD:197706 15/73 (21%)
PTK_CCK4 686..1026 CDD:133178 99/365 (27%)
STYKc 692..1020 CDD:214568 96/351 (27%)
ROR2NP_004551.2 I-set 64..152 CDD:254352 23/88 (26%)
IGc2 75..141 CDD:197706 18/65 (28%)
CRD_TK_ROR2 170..309 CDD:143577 28/156 (18%)
KR 314..395 CDD:214527 11/80 (14%)
PTKc_Ror2 466..749 CDD:270673 84/287 (29%)
Pkinase_Tyr 473..746 CDD:285015 81/278 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..931
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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