DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment otk and ROR1

DIOPT Version :9

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_005003.2 Gene:ROR1 / 4919 HGNCID:10256 Length:937 Species:Homo sapiens


Alignment Length:799 Identity:178/799 - (22%)
Similarity:313/799 - (39%) Gaps:165/799 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   334 KQNGT-------LSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKF--VPQPTSKNLE 389
            ::.||       |:...:.|..|...:.:|.:.|.....||..|...:.:..:  :.:|.:....
Human     5 RRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITT 69

  Fly   390 LDAVVAKVHCKAQGTPTPQVQWVR-DGENTTLPDHVEVDA---NGTLIFRNVNSEHRGNYTCLAT 450
            .....|::|||..|.|.|.::|.: |......|..:...:   ...|..||:::...|.:.|:||
Human    70 SLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVAT 134

  Fly   451 NSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTD 515
            |.:..:::|..:.|    ||..||......|::......||    |...|..             
Human   135 NGKEVVSSTGVLFV----KFGPPPTASPGYSDEYEEDGFCQ----PYRGIAC------------- 178

  Fly   516 RERFRFLENGTLEIRNVQVEDEGSYGCT-----IGNSAGLKREDVQLVVKT-----------TGD 564
               .||:.|.|:.:.::.::.|.....|     ||.|:.|..:..|..:.:           |..
Human   179 ---ARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS 240

  Fly   565 GFAPEESGGDGFLVTRAVL-------------ITMTVAL-------------AYIVLVVGLMLWC 603
            ...|.:...|...:...||             |.|.:.|             |...:.:|:.:  
Human   241 VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPM-- 303

  Fly   604 RYRRQARKARLNDLSTKEAGGD-QPDVAGNGKGSEQEPCLSKQ--------------HNGHSKSR 653
                 |.....|.......|.| :..|:....|.:.:|..|:.              :.|||..|
Human   304 -----ADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCR 363

  Fly   654 SKSSGDAQKS----------------DDTAC-SQQSRASKKSAHIYEQLALPRSGLSELIQIGRG 701
            :..:   ||.                |..|| |:.|:...|...:|  :.:|...:...|.:   
Human   364 NPGN---QKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILY--ILVPSVAIPLAIAL--- 420

  Fly   702 EFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNE-KRRSK------TS 759
            .|..:.|.:......::|..:    :.:|...:|         ..:|.||. |.:||      ::
Human   421 LFFFICVCRNNQKSSSAPVQR----QPKHVRGQN---------VEMSMLNAYKPKSKAKELPLSA 472

  Fly   760 MDDIEEIKEEEQDQHNQSGL-------EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVR 817
            :..:||:.|....:..:..|       .|||.:|.|....:.|...||:::..|:..:.|..:|.
Human   473 VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVC 537

  Fly   818 LFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSS------PPPLTTSQVLAVAYQI 876
            |.|...::.|..|:.||.:.|||.:||:..:..   :..|.||      ...|.....|.:|.||
Human   538 LLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPH---SDVGCSSDEDGTVKSSLDHGDFLHIAIQI 599

  Fly   877 ARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECI 940
            |.||:.:....|.|:|||.||.:|..:..||:|...|.::.||.:|:: ...:||||||:.||.|
Human   600 AAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAI 664

  Fly   941 QEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLS 1005
            ...::::.|||:::|||:||:|:...: |:...:|::|::..:...| ...:|..|..:..::..
Human   665 MYGKFSSDSDIWSFGVVLWEIFSFGLQ-PYYGFSNQEVIEMVRKRQL-LPCSEDCPPRMYSLMTE 727

  Fly  1006 CWVSNPKERPSFSQLGAAL 1024
            ||...|..||.|..:...|
Human   728 CWNEIPSRRPRFKDIHVRL 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 I-set 26..115 CDD:254352
Ig 31..115 CDD:299845
IGc2 133..195 CDD:197706
Ig 268..373 CDD:299845 10/45 (22%)
Ig 395..460 CDD:143165 18/68 (26%)
I-set 468..559 CDD:254352 20/95 (21%)
IGc2 484..549 CDD:197706 13/69 (19%)
PTK_CCK4 686..1026 CDD:133178 96/360 (27%)
STYKc 692..1020 CDD:214568 94/348 (27%)
ROR1NP_005003.2 IG_like 66..148 CDD:214653 19/81 (23%)
CRD_TK_ROR1 166..307 CDD:143576 26/167 (16%)
KR 311..393 CDD:214527 15/84 (18%)
PTKc_Ror1 467..749 CDD:270672 83/285 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..779
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..890
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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