DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and ROR1

DIOPT Version :10

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_005003.2 Gene:ROR1 / 4919 HGNCID:10256 Length:937 Species:Homo sapiens


Alignment Length:799 Identity:178/799 - (22%)
Similarity:313/799 - (39%) Gaps:165/799 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   334 KQNGT-------LSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKF--VPQPTSKNLE 389
            ::.||       |:...:.|..|...:.:|.:.|.....||..|...:.:..:  :.:|.:....
Human     5 RRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITT 69

  Fly   390 LDAVVAKVHCKAQGTPTPQVQWVR-DGENTTLPDHVEVDA---NGTLIFRNVNSEHRGNYTCLAT 450
            .....|::|||..|.|.|.::|.: |......|..:...:   ...|..||:::...|.:.|:||
Human    70 SLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVAT 134

  Fly   451 NSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTD 515
            |.:..:::|..:.|    ||..||......|::......||    |...|..             
Human   135 NGKEVVSSTGVLFV----KFGPPPTASPGYSDEYEEDGFCQ----PYRGIAC------------- 178

  Fly   516 RERFRFLENGTLEIRNVQVEDEGSYGCT-----IGNSAGLKREDVQLVVKT-----------TGD 564
               .||:.|.|:.:.::.::.|.....|     ||.|:.|..:..|..:.:           |..
Human   179 ---ARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS 240

  Fly   565 GFAPEESGGDGFLVTRAVL-------------ITMTVAL-------------AYIVLVVGLMLWC 603
            ...|.:...|...:...||             |.|.:.|             |...:.:|:.:  
Human   241 VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPM-- 303

  Fly   604 RYRRQARKARLNDLSTKEAGGD-QPDVAGNGKGSEQEPCLSKQ--------------HNGHSKSR 653
                 |.....|.......|.| :..|:....|.:.:|..|:.              :.|||..|
Human   304 -----ADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCR 363

  Fly   654 SKSSGDAQKS----------------DDTAC-SQQSRASKKSAHIYEQLALPRSGLSELIQIGRG 701
            :..:   ||.                |..|| |:.|:...|...:|  :.:|...:...|.:   
Human   364 NPGN---QKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILY--ILVPSVAIPLAIAL--- 420

  Fly   702 EFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNE-KRRSK------TS 759
            .|..:.|.:......::|..:    :.:|...:|         ..:|.||. |.:||      ::
Human   421 LFFFICVCRNNQKSSSAPVQR----QPKHVRGQN---------VEMSMLNAYKPKSKAKELPLSA 472

  Fly   760 MDDIEEIKEEEQDQHNQSGL-------EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVR 817
            :..:||:.|....:..:..|       .|||.:|.|....:.|...||:::..|:..:.|..:|.
Human   473 VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVC 537

  Fly   818 LFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSS------PPPLTTSQVLAVAYQI 876
            |.|...::.|..|:.||.:.|||.:||:..:..   :..|.||      ...|.....|.:|.||
Human   538 LLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPH---SDVGCSSDEDGTVKSSLDHGDFLHIAIQI 599

  Fly   877 ARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECI 940
            |.||:.:....|.|:|||.||.:|..:..||:|...|.::.||.:|:: ...:||||||:.||.|
Human   600 AAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAI 664

  Fly   941 QEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLS 1005
            ...::::.|||:::|||:||:|:...: |:...:|::|::..:...| ...:|..|..:..::..
Human   665 MYGKFSSDSDIWSFGVVLWEIFSFGLQ-PYYGFSNQEVIEMVRKRQL-LPCSEDCPPRMYSLMTE 727

  Fly  1006 CWVSNPKERPSFSQLGAAL 1024
            ||...|..||.|..:...|
Human   728 CWNEIPSRRPRFKDIHVRL 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 Ig_3 31..99 CDD:464046
Ig strand B 133..137 CDD:409353
Ig <135..197 CDD:472250
Ig strand C 150..154 CDD:409353
Ig strand E 171..175 CDD:409353
Ig strand F 185..190 CDD:409353
Ig 265..360 CDD:472250 6/32 (19%)
Ig strand B 272..276 CDD:409571
Ig strand C 290..294 CDD:409571
Ig strand E 337..341 CDD:409571 3/10 (30%)
Ig strand F 351..356 CDD:409571 0/4 (0%)
Ig 395..460 CDD:409353 18/68 (26%)
Ig strand B 395..399 CDD:409353 1/3 (33%)
Ig strand C 408..412 CDD:409353 0/3 (0%)
Ig strand E 430..434 CDD:409353 1/3 (33%)
Ig strand F 444..449 CDD:409353 1/4 (25%)
Ig strand G 457..460 CDD:409353 0/2 (0%)
I-set 468..559 CDD:400151 20/95 (21%)
Ig strand B 486..490 CDD:409570 0/3 (0%)
Ig strand C 499..503 CDD:409570 1/3 (33%)
Ig strand E 525..529 CDD:409570 1/3 (33%)
Ig strand F 539..544 CDD:409570 1/9 (11%)
Ig strand G 552..555 CDD:409570 0/2 (0%)
PTK_CCK4 686..1026 CDD:133178 96/360 (27%)
ROR1NP_005003.2 IG_like 66..148 CDD:214653 19/81 (23%)
Ig strand B 75..79 CDD:409570 1/3 (33%)
Ig strand C 88..92 CDD:409570 0/3 (0%)
Ig strand E 114..118 CDD:409570 1/3 (33%)
Ig strand F 128..133 CDD:409570 1/4 (25%)
Ig strand G 141..144 CDD:409570 0/2 (0%)
CRD_TK_ROR1 166..307 CDD:143576 26/167 (16%)
KR 311..393 CDD:214527 15/84 (18%)
PTKc_Ror1 467..749 CDD:270672 83/285 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..779
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..890
Blue background indicates that the domain is not in the aligned region.

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