DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otk and NTRK3

DIOPT Version :9

Sequence 1:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens

Alignment Length:	1063	Identity:	244/1063 - (22%)
Similarity:	370/1063 - (34%)	Gaps:	387/1063 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEG--ASGDLE 147
            ||.:| ||...:.....||....            :||:.:...:||  :...|:|.  :...|.
Human    46 RRPDD-GNLFPLLEGQDSGNSNG------------NASINITDISRN--ITSIHIENWRSLHTLN 95

  Fly   148 PLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCL 212
            .:::|.|...:|| |.||..|   |.|  ||        |..|.|...|      |:..||
Human    96 AVDMELYTGLQKL-TIKNSGL---RSI--QP--------RAFAKNPHLR------YINLSS---- 136

  Fly   213 PRLPRRKNEKMMESWDK-QTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTC 276
                   |.....||.. ||.                    .||.:|
Human   137 -------NRLTTLSWQLFQTL--------------------SLRELQ------------------ 156

  Fly   277 LYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSF 341
               |.....|....:||.:                           |.:|.....|:.||
Human   157 ---LEQNFFNCSCDIRWMQ---------------------------LWQEQGEAKLNSQN----- 186

  Fly   342 ASIIASDAGQY--------QCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLEL------DA 392
            ...|.:|..|.        ||.|                        |:.:..::.|      :|
Human   187 LYCINADGSQLPLFRMNISQCDL------------------------PEISVSHVNLTVREGDNA 227

  Fly   393 VVAKVHCKAQGTPTPQVQWVRDG------ENTTLPDHVEVDA-NGTLIFRNVNSEHRG-NYTCLA 449
            |:.   |...|:|.|.|.|:..|      ..|.| :...|.| |.||:  ||.||..| ..||:|
Human   228 VIT---CNGSGSPLPDVDWIVTGLQSINTHQTNL-NWTNVHAINLTLV--NVTSEDNGFTLTCIA 286

  Fly   450 TNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAI---GDPKPTIQWDKDLKYLSE 511
            .|..|..||:||:.|...|:.       :...|....:.||...   |:|.||:.|
Human   287 ENVVGMSNASVALTVYYPPRV-------VSLEEPELRLEHCIEFVVRGNPPPTLHW--------- 335

  Fly   512 NNTDRERFRFLENG----TLEIRNVQVEDEG--SYGCTI---------GNSAGLKREDVQLVVKT 561
                      |.||    ..:|.:|:...||  |.||.:         ||...:.:..:....:|
Human   336 ----------LHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQT 390

  Fly   562 TGDGFA----PEESGGDGFL----VTRAVLITMT----------------VALAYIVLVVGLMLW 602
            ....|.    ||.:  |.|:    |:....||:|                .|.|.::|||..::.
Human   391 INGHFLKEPFPEST--DNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMI 453

  Fly   603 CRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTA 667
            .:|.|:::           .|...|....:|:.....|.   .|..|..: :.||.||  ..||.
Human   454 NKYGRRSK-----------FGMKGPVAVISGEEDSASPL---HHINHGIT-TPSSLDA--GPDTV 501

  Fly   668 CSQQSR---------------ASKKSAHIY----EQLALPRSGLSELIQIGRGEFGDVFVGKLKA 713
            ....:|               ..|...::.    ..:.|.|       ::|.|.||.||:.:
Human   502 VIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKR-------ELGEGAFGKVFLAE--- 556

  Fly   714 TLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSG 778
                                          ...||...:|
Human   557 ------------------------------CYNLSPTKDK------------------------- 566

  Fly   779 LEQLVLVKALNKVKDE--QACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLK 841
              .||.||||   ||.  .|.::|:|:.:||..:.|:.:|:.:|:|.:.||..||.||...|||.
Human   567 --MLVAVKAL---KDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLN 626

  Fly   842 QFLLATAGKVNTATAGS--SSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEF 904
            :||.|..........|.  .:...|..||:|.:|.|||.||..:....|.|||||||||::.:..
Human   627 KFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL 691

  Fly   905 IVKVSYPALCKDKYSREYHKH--------------------------RNTLLPIRWLAPECIQED 943
            :||:....:.:|.||.:|::.                          .:|:|||||:.||.|...
Human   692 LVKIGDFGMSRDVYSTDYYREGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYR 756

  Fly   944 EYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQ-RSQAGSLEWSVAEATPDSLREILLSCW 1007
            ::||:||::::||::||:|... |.|..:|:|.:|:: .:|...||  .....|..:.:::|.||
Human   757 KFTTESDVWSFGVILWEIFTYG-KQPWFQLSNTEVIECITQGRVLE--RPRVCPKEVYDVMLGCW 818

  Fly  1008 VSNPKERPSFSQLGA---ALSKA 1027
            ...|::|.:..::..   ||.||
Human   819 QREPQQRLNIKEIYKILHALGKA 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otk	NP_523705.2	I-set	26..115	CDD:254352	7/29 (24%)
		Ig	31..115	CDD:299845	7/29 (24%)
		IGc2	133..195	CDD:197706	18/63 (29%)
		Ig	268..373	CDD:299845	15/112 (13%)
		Ig	395..460	CDD:143165	26/72 (36%)
		I-set	468..559	CDD:254352	21/108 (19%)
		IGc2	484..549	CDD:197706	19/82 (23%)
		PTK_CCK4	686..1026	CDD:133178	101/373 (27%)
		STYKc	692..1020	CDD:214568	97/358 (27%)
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566	26/128 (20%)
		leucine-rich repeat	105..128	CDD:275378	13/36 (36%)
		leucine-rich repeat	129..151	CDD:275378	9/58 (16%)
		leucine-rich repeat	152..164	CDD:275378	4/32 (13%)
		TPKR_C2	163..208	CDD:293525	12/76 (16%)
		Ig_TrkABC_d4	211..301	CDD:143173	31/95 (33%)
		IG_like	218..301	CDD:214653	31/88 (35%)
		Ig_TrKABC_d5	319..396	CDD:143172	20/95 (21%)
		PTKc_TrkC	532..843	CDD:270676	103/383 (27%)
		TyrKc	538..835	CDD:197581	99/369 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810