DRSC/TRiP Functional Genomics Resources

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Protein Alignment otk and NTRK2

DIOPT Version :10

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:NP_006171.2 Gene:NTRK2 / 4915 HGNCID:8032 Length:838 Species:Homo sapiens


Alignment Length:1095 Identity:240/1095 - (21%)
Similarity:391/1095 - (35%) Gaps:343/1095 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ARMISICGLVMALMMA------SVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLH 61
            ||:...|.||:....|      |...|:||......|..:|....::......::.:|:.     
Human    13 ARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIF----- 72

  Fly    62 NGHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCI--ATNLASGAREASPPAKLSVIYLESASVQ 124
                ||..||:..|..          :||..||.:  .|.:.||.:..:..|     :|:::::|
Human    73 ----IANQKRLEIINE----------DDVEAYVGLRNLTIVDSGLKFVAHKA-----FLKNSNLQ 118

  Fly   125 LLGSNRNEL--LLKCHVEGASGDLEPL-----------EIEWYRNSEKLSTWKNVQLDQHRLIIR 176
            .:...||:|  |.:.|....  ||..|           :|.|.:..::..:              
Human   119 HINFTRNKLTSLSRKHFRHL--DLSELILVGNPFTCSCDIMWIKTLQEAKS-------------- 167

  Fly   177 QPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLP----RLPRRKNEKMMESWDKQTFLCRGK 237
            .|.::|                   .|....|.|.:|    ::|.                    
Human   168 SPDTQD-------------------LYCLNESSKNIPLANLQIPN-------------------- 193

  Fly   238 RGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQ 302
                .||.:...|..:|          .::||:...|:|                          
Human   194 ----CGLPSANLAAPNL----------TVEEGKSITLSC-------------------------- 218

  Fly   303 VELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAG-QYQC-------QLQLE 359
             .:.|. |:|...:|.|.  |:.:......|.| |:|...:|.:.|:| |..|       :.|..
Human   219 -SVAGD-PVPNMYWDVGN--LVSKHMNETSHTQ-GSLRITNISSDDSGKQISCVAENLVGEDQDS 278

  Fly   360 AHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVH-C---KAQGTPTPQVQWVRDG----E 416
            .:..::.:|.|       .|:..|||.:          | |   ..:|.|.|.:||..:|    |
Human   279 VNLTVHFAPTI-------TFLESPTSDH----------HWCIPFTVKGNPKPALQWFYNGAILNE 326

  Fly   417 NTTLPDHVEV----DANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGP 477
            :..:...:.|    :.:|.|...|....:.|:||.:|.|..|                       
Human   327 SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG----------------------- 368

  Fly   478 IETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFL------ENGTLEIRNVQVED 536
                                      ||.|.:|.:        |:      :.......:|..||
Human   369 --------------------------KDEKQISAH--------FMGWPGIDDGANPNYPDVIYED 399

  Fly   537 EGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLML 601
            .|:....||::.....|     :.:|.   ..:::|.:...|...|:|...|....:|::..|.|
Human   400 YGTAANDIGDTTNRSNE-----IPSTD---VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKL 456

  Fly   602 WCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDT 666
                   ||.::..          ..|.:..|.|..:    |:|..|.:   |..|.|    ||:
Human   457 -------ARHSKFG----------MKDFSWFGFGKVK----SRQGVGPA---SVISND----DDS 493

  Fly   667 ACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSP-------SDKDA 724
            |....        ||......|.|        ..|....|.:|..|..::.:|       |....
Human   494 ASPLH--------HISNGSNTPSS--------SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKP 542

  Fly   725 DTEKQHSNSEN-------GSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQL 782
            ||..||....|       |.|..|               |..:.:...:..|:.        :.|
Human   543 DTFVQHIKRHNIVLKRELGEGAFG---------------KVFLAECYNLCPEQD--------KIL 584

  Fly   783 VLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLAT 847
            |.||.|....| .|.::|.|:.:||..:.|:.:|:.:|:|.|.||..||.||...|||.:||.| 
Human   585 VAVKTLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA- 647

  Fly   848 AGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPA 912
            .|......|..:.|..||.||:|.:|.|||.||..:....|.|||||||||::....:||:....
Human   648 HGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFG 712

  Fly   913 LCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNE 976
            :.:|.||.:|:: ..:|:|||||:.||.|...::||:||:::.|||:||:|... |.|..:|:|.
Human   713 MSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG-KQPWYQLSNN 776

  Fly   977 QVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSA 1031
            :|::....|.: .......|..:.|::|.||...|..|.:...:...|....:::
Human   777 EVIECITQGRV-LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKAS 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 Ig_3 31..99 CDD:464046 12/69 (17%)
Ig strand B 133..137 CDD:409353 2/5 (40%)
Ig <135..197 CDD:472250 8/72 (11%)
Ig strand C 150..154 CDD:409353 1/3 (33%)
Ig strand E 171..175 CDD:409353 0/3 (0%)
Ig strand F 185..190 CDD:409353 0/4 (0%)
Ig 265..360 CDD:472250 20/102 (20%)
Ig strand B 272..276 CDD:409571 1/3 (33%)
Ig strand C 290..294 CDD:409571 0/3 (0%)
Ig strand E 337..341 CDD:409571 2/3 (67%)
Ig strand F 351..356 CDD:409571 2/11 (18%)
Ig 395..460 CDD:409353 19/76 (25%)
Ig strand B 395..399 CDD:409353 1/4 (25%)
Ig strand C 408..412 CDD:409353 1/3 (33%)
Ig strand E 430..434 CDD:409353 2/3 (67%)
Ig strand F 444..449 CDD:409353 2/4 (50%)
Ig strand G 457..460 CDD:409353 0/2 (0%)
I-set 468..559 CDD:400151 12/96 (13%)
Ig strand B 486..490 CDD:409570 0/3 (0%)
Ig strand C 499..503 CDD:409570 0/3 (0%)
Ig strand E 525..529 CDD:409570 0/3 (0%)
Ig strand F 539..544 CDD:409570 0/4 (0%)
Ig strand G 552..555 CDD:409570 1/2 (50%)
PTK_CCK4 686..1026 CDD:133178 109/354 (31%)
NTRK2NP_006171.2 LRR_8 92..150 CDD:404697 14/64 (22%)
LRR 1 92..113 4/25 (16%)
LRR 2 116..137 6/20 (30%)
LRRCT_2 151..195 CDD:465313 9/100 (9%)
Ig 205..283 CDD:472250 21/118 (18%)
Ig strand B 214..218 CDD:409353 1/3 (33%)
Ig strand C 227..230 CDD:409353 0/2 (0%)
Ig strand E 245..252 CDD:409353 4/7 (57%)
Ig strand F 262..268 CDD:409353 2/5 (40%)
Ig strand G 276..279 CDD:409353 1/2 (50%)
IgI_TrkB_d5 286..379 CDD:409441 29/166 (17%)
Ig strand A 286..294 CDD:409441 3/14 (21%)
Ig strand A' 295..298 CDD:409441 2/2 (100%)
Ig strand B 301..309 CDD:409441 1/7 (14%)
Ig strand C 312..319 CDD:409441 3/6 (50%)
Ig strand C' 322..325 CDD:409441 0/2 (0%)
Ig strand D 330..335 CDD:409441 0/4 (0%)
Ig strand E 341..349 CDD:409441 2/7 (29%)
Ig strand F 357..365 CDD:409441 4/7 (57%)
Ig strand G 368..376 CDD:409441 4/56 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..514 8/38 (21%)
PTKc_TrkB 548..835 CDD:270675 98/310 (32%)

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