DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment otk and MUSK

DIOPT Version :10

Sequence 1:NP_523705.2 Gene:otk / 36283 FlyBaseID:FBgn0004839 Length:1033 Species:Drosophila melanogaster
Sequence 2:XP_005252051.1 Gene:MUSK / 4593 HGNCID:7525 Length:879 Species:Homo sapiens


Alignment Length:1095 Identity:241/1095 - (22%)
Similarity:396/1095 - (36%) Gaps:386/1095 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 VCIATNLASGAREASPPAKLSVIYLES--ASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRN 156
            |.|.|.:|....|..|.|.:....||:  |.|:.:.:      ..|.||...   :| ||.|.||
Human    10 VHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVAT------FMCAVESYP---QP-EISWTRN 64

  Fly   157 -------SEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPR 214
                   ..:.|..:|.||    |.|......|||:|.|||:|..|..:...|.:   .||..|:
Human    65 KILIKLFDTRYSIRENGQL----LTILSVEDSDDGIYCCTANNGVGGAVESCGAL---QVKMKPK 122

  Fly   215 LPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYE 279
            :.|                                         .||...|| ||....|.|   
Human   123 ITR-----------------------------------------PPINVKII-EGLKAVLPC--- 142

  Fly   280 LPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASI 344
              ..:.|.:..:.|.|           |.:|             |||::|:.: .::|:|...::
Human   143 --TTMGNPKPSVSWIK-----------GDSP-------------LRENSRIAV-LESGSLRIHNV 180

  Fly   345 IASDAGQYQCQLQLEAHAPINSSPGI-------LEVIEQ----------LKFVPQPTSKNLELDA 392
            ...|||||:|..:        :|.|.       |||.|:          .:.:..|.|.|:...:
Human   181 QKEDAGQYRCVAK--------NSLGTAYSKVVKLEVEEESEPEQDTKVFARILRAPESHNVTFGS 237

  Fly   393 VVAKVHCKAQGTPTPQVQWVRDGE-------NTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLAT 450
            .|. :||.|.|.|.|.:.|:.:|.       ..::.|.| :|:...|....     .|.|||:||
Human   238 FVT-LHCTATGIPVPTITWIENGNAVSSGSIQESVKDRV-IDSRLQLFITK-----PGLYTCIAT 295

  Fly   451 NSQGQINATV-AINVVVTPKFSVPPVGPIETSEQGTVVMH----CQAI-------------GDPK 497
            |..|:..:|. |...:...::|.|     :...:|....:    |.|:             .||:
Human   296 NKHGEKFSTAKAAATISIAEWSKP-----QKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPE 355

  Fly   498 PTIQ------WDKDLKYLS-------ENNTDRERFRFLENGT------------LEIRNV----- 532
            ...:      |: :||.:|       |.......|:....|.            |.::.:     
Human   356 EAQELLVHTAWN-ELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKE 419

  Fly   533 -QVEDEGSYGCTIGNSAGLKREDVQLV------------------------------VKTTGDGF 566
             .|.:|.::       .||.|.::.|:                              :||    |
Human   420 WLVMEEKTH-------RGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKT----F 473

  Fly   567 AP-------------EESGGDGFLVTRAVLITMTVAL-----AYIVLVVGLMLWCRYRRQ----A 609
            .|             ..|....|.|:....:|:.:::     .:::|.:..:..||.|:|    .
Human   474 PPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKK 538

  Fly   610 RKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRA 674
            |::....|:|..:                |..|.:.|..                          
Human   539 RESAAVTLTTLPS----------------ELLLDRLHPN-------------------------- 561

  Fly   675 SKKSAHIYEQLAL-----------PRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEK 728
                 .:|:::.|           ||:.:..:..||.|.||.||..:....|...|         
Human   562 -----PMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP--------- 612

  Fly   729 QHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKD 793
                                         .:|..::.:|||..                    .|
Human   613 -----------------------------FTMVAVKMLKEEAS--------------------AD 628

  Fly   794 EQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFL----------LATA 848
            .||  :|:|:..|:....:..:|:|.|:|....|..::.||..:|||.:||          |:.:
Human   629 MQA--DFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS 691

  Fly   849 GKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPAL 913
            .....|...|..||||:.::.|.:|.|:|.||..:...:|.|||||||||::....:||::...|
Human   692 DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGL 756

  Fly   914 CKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQ 977
            .::.||.:|:| :.|..:||||:.||.|..:.|||:||::|||||:||:|:...: |:..:.:|:
Human   757 SRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQ-PYYGMAHEE 820

  Fly   978 VVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSAE 1032
            |:...:.|:: .|..|..|..|..::..||...|.:||||:.:...|.:..:.||
Human   821 VIYYVRDGNI-LSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAE 874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
otkNP_523705.2 Ig_3 31..99 CDD:464046 2/4 (50%)
Ig strand B 133..137 CDD:409353 0/3 (0%)
Ig <135..197 CDD:472250 24/68 (35%)
Ig strand C 150..154 CDD:409353 2/3 (67%)
Ig strand E 171..175 CDD:409353 1/3 (33%)
Ig strand F 185..190 CDD:409353 2/4 (50%)
Ig 265..360 CDD:472250 23/94 (24%)
Ig strand B 272..276 CDD:409571 1/3 (33%)
Ig strand C 290..294 CDD:409571 0/3 (0%)
Ig strand E 337..341 CDD:409571 2/3 (67%)
Ig strand F 351..356 CDD:409571 3/4 (75%)
Ig 395..460 CDD:409353 20/71 (28%)
Ig strand B 395..399 CDD:409353 0/3 (0%)
Ig strand C 408..412 CDD:409353 0/3 (0%)
Ig strand E 430..434 CDD:409353 1/3 (33%)
Ig strand F 444..449 CDD:409353 3/4 (75%)
Ig strand G 457..460 CDD:409353 0/2 (0%)
I-set 468..559 CDD:400151 21/168 (13%)
Ig strand B 486..490 CDD:409570 0/7 (0%)
Ig strand C 499..503 CDD:409570 0/9 (0%)
Ig strand E 525..529 CDD:409570 2/15 (13%)
Ig strand F 539..544 CDD:409570 0/4 (0%)
Ig strand G 552..555 CDD:409570 1/2 (50%)
PTK_CCK4 686..1026 CDD:133178 101/361 (28%)
MUSKXP_005252051.1 IgI_1_MuSK 28..117 CDD:409562 29/105 (28%)
Ig strand A 28..31 CDD:409562 0/2 (0%)
Ig strand A' 35..39 CDD:409562 1/3 (33%)
Ig strand B 45..52 CDD:409562 1/12 (8%)
Ig strand C 58..63 CDD:409562 3/4 (75%)
Ig strand C' 65..67 CDD:409562 0/1 (0%)
Ig strand D 75..78 CDD:409562 1/2 (50%)
Ig strand E 82..88 CDD:409562 4/9 (44%)
Ig strand F 95..102 CDD:409562 4/6 (67%)
Ig strand G 109..117 CDD:409562 1/10 (10%)
Ig 122..206 CDD:472250 28/163 (17%)
Ig strand B 138..142 CDD:409353 1/3 (33%)
Ig strand C 151..155 CDD:409353 0/3 (0%)
Ig strand E 173..177 CDD:409353 2/3 (67%)
Ig strand F 187..192 CDD:409353 3/4 (75%)
Ig strand G 201..204 CDD:409353 0/2 (0%)
Ig_3 228..296 CDD:464046 21/74 (28%)
CRD_FZ 325..467 CDD:470581 19/149 (13%)
PTKc_Musk 579..868 CDD:133181 100/350 (29%)

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